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Evaluation of vascular reactivity of young male hypogonadotrophic hypogonadism patients

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Abstract

We aimed to study the vascular reactivity of young male hypogonadal hypogonadism patients without any cardiovascular risk factors and compare these findings with the ones of age-matched healthy controls. Study population consisted of 26 young male hypogonadotrophic hypogonadism patients (20.9 ± 1.3 years) and 25 age-matched healthy male controls (21.8 ± 2.9 years, P = NS). In addition to detailed hormonal analysis, each subject underwent ultrasound study of right brachial artery. Vessel diameter was measured at rest, during reactive hyperemia [endothelium-dependent flow-mediated vasodilation (FMD)] and after sublingual nitroglycerin administration (endothelium-independent vasodilation). Both flow-mediated and endothelium-independent sublingual nitroglycerin mediated dilatation values of patients were higher compared to controls (12.98 ± 10.76% vs. 7.92 ± 1.96%, P = 0.003 and 21.44 ± 10.36% vs. 14.72 ± 3.57%, P = 0.023, respectively). Linear regression analysis revealed that only serum HDL levels (relative risk 2.94, 95% CI 0.12–0.66, P = 0.006) and baseline vessel diameter (relative risk −2.77, 95% CI −17.73 to −2.70, P = 0.009) were found to be independently associated with FMD values. Endogenous male sex hormones seem to exert negative effects on vascular reactivity parameters and much of their effects are indirect that is by the way of alteration on lipid profile.

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References

  1. Kalin MF, Zumoff B (1990) Sex hormones and coronary artery disease: a review of the clinical studies. Steroids 55:330–352

    Article  CAS  PubMed  Google Scholar 

  2. Liu PY, Death AK, Handelsman DJ (2003) Androgens and cardiovascular disease. Endocr Rev 24:313–340

    Article  CAS  PubMed  Google Scholar 

  3. Lerner DJ, Kannel WB (1986) Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J 111:383–390

    Article  CAS  PubMed  Google Scholar 

  4. Adams MR, Kaplan JR, Manuck SB et al (1990) Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys: lack of an effect of added progesterone. Atherosclerosis 10:1051–1057

    CAS  Google Scholar 

  5. Wagner JD, Clarkson TB, Clair RWS, Schwenke DC, Shively CA, Adams MR (1991) Estrogen and progesterone replacement therapy reduces low density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys. J Clin Invest 88:1995–2002

    Google Scholar 

  6. Kaplan JR, Manuck SB, Anthony MS, Clarkson TB (2002) Premenopausal social status and hormone exposure predict postmenopausal atherosclerosis in female monkeys. Obstet Gynecol 99:381–388

    Article  CAS  PubMed  Google Scholar 

  7. Paoletti R, Cosignani PG, Kenemans P et al (1997) Menopause: problems and interventions in the United States. In: Paoletti R, Cosignani PG, Kenemans P, Samsoe G, Soma M, Jackson AS (eds) Women’s health and menopause. Kluwer Academic Publishers, Norwell, MA, pp 9–14

  8. Liu PY, Death AK, Handelsman DJ et al (2003) Androgens and cardiovascular disease. Endocr Rev 24:313–340

    Article  CAS  PubMed  Google Scholar 

  9. Hanke H, Lenz C, Hess B et al (2001) Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall. Circulation 103:1382–1385

    CAS  PubMed  Google Scholar 

  10. Larsen BA, Nordestgaard BG, Stender S et al (1993) Effect of testosterone on atherogenesis in cholesterol-fed rabbits with similar plasma cholesterol levels. Atherosclerosis 99:79–86

    Article  CAS  PubMed  Google Scholar 

  11. Nathan L, Shi W, Dinh H et al (2001) Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci USA 98:3589–3593

    Article  CAS  PubMed  Google Scholar 

  12. Alexandersen P, Haarbo J, Byrjalsen I et al (1999) Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits. Circ Res 84:813–819

    CAS  PubMed  Google Scholar 

  13. Bruck B, Brehme U, Gugel N et al (1997) Gender-specific differences in the effects of testosterone and estrogen on the development of atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol 17:2192–2199

    CAS  PubMed  Google Scholar 

  14. Deenadayalu VP, White RE, Stallone JN et al (2001) Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. Am J Physiol Heart Circ Physiol 281:1720–1727

    Google Scholar 

  15. Yue P, Chatterjee K, Beale C et al (1995) Testosterone relaxes rabbit coronary arteries and aorta. Circulation 91:1154–1160

    CAS  PubMed  Google Scholar 

  16. Moens AL, Goovaerts I, Claeys MJ et al (2005) Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? Chest 127:2254–2263

    Article  PubMed  Google Scholar 

  17. McCredie RJ, McCrohon JA, Turner L et al (1998) Vascular reactivity is impaired in genetic females taking high-dose androgens. J Am Coll Cardiol 32:1331–1335

    Article  CAS  PubMed  Google Scholar 

  18. Herman MS, Robinson JTC, McCredie RJ et al (1997) Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men. Arterioscler Thromb Vasc Biol 17:2004–2009

    CAS  PubMed  Google Scholar 

  19. Sader MA, Griffiths KA, McCredie RJ et al (2001) Androgenic anabolic steroids and arterial structure and function in male bodybuilders. J Am Coll Cardiol 37:224–230

    Article  CAS  PubMed  Google Scholar 

  20. Zitzmann M, Brune M, Nieschlag E et al (2002) Vascular reactivity in hypogonadal men is reduced by androgen substitution. J Clin Endocrinol Metab 87:5030–5037

    Article  CAS  PubMed  Google Scholar 

  21. Bernini G, Versari D, Moretti A et al (2006) Vascular reactivity in congenital hypogonadal men before and after testosterone replacement therapy. J Clin Endocrinol Metab 91:1691–1697

    Article  CAS  PubMed  Google Scholar 

  22. Sader MA, Griffiths KA, Skilton MR et al (2003) Physiological testosterone replacement and arterial endothelial function in men. Clin Endocrinol 59:62–67

    Article  CAS  Google Scholar 

  23. Webb OL, Laskarzewski PM, Glueck CJ (1984) Severe depression of high-density lipoprotein cholesterol levels in weight lifters and body builders by self-administered exogenous testosterone and anabolic androgenic steroids. Metabolism 33:971–975

    Article  CAS  PubMed  Google Scholar 

  24. Thompson PD, Cullinane EM, Sady SP et al (1989) Contrasting effects of testosterone and stanazolol on serum lipoprotein levels. JAMA 261:1165–1168

    Article  CAS  PubMed  Google Scholar 

  25. Anderson TJ, Uehata A, Gerhard MD et al (1995) Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 26:1235–1241

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Gülhane Military Academy and Medical Faculty, Ankara, Turkey.

    Ferhat Deniz & Mustafa Kutlu

  2. Department of Cardiology, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey

    Necip Ermiş

  3. Cardiology Clinic, Eskişehir Yunus Emre State Hospital, Eskisehir, Turkey

    Alper Kepez

  4. Radiology Clinic, Etimesgut Military Hospital, Ankara, Turkey

    Barış Türk, Murat Akkoyunlu & Batuhan Kara

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  1. Ferhat Deniz
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  2. Necip Ermiş
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  3. Alper Kepez
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  4. Barış Türk
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  5. Murat Akkoyunlu
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  6. Batuhan Kara
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  7. Mustafa Kutlu
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Correspondence to Alper Kepez.

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Deniz, F., Ermiş, N., Kepez, A. et al. Evaluation of vascular reactivity of young male hypogonadotrophic hypogonadism patients. Int J Cardiovasc Imaging 26, 35–40 (2010). https://doi.org/10.1007/s10554-009-9505-7

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  • DOI: https://doi.org/10.1007/s10554-009-9505-7

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