Abstract
Background
There is limited information regarding left atrial (LA) systolic adaptation to chronic heart failure (HF) in humans. Therefore, the aim of our study was to determine the LA ejection force (LAEF) and kinetic energy in patients with HF.
Methods and results
58 HF patients (63.8% in NYHA II) and 48 controls were studied. LA volumes were echocardiographically determined using the biplane area-length method. LA systolic function was assessed with the: (a) active emptying volume (ACTEV) and fraction (ACTEF), (b) ejection force (kdynes/m2), calculated with Manning’s method [LAEF = 0.5 * ρ * mitral orifice area * A2; ρ: blood density, Α: late transmitral flow velocity] and a modification incorporating parameters of LA function [LAEFm = 0.5 * ρ * LA volume at onset of atrial systole * ACTEF * A2/VTlA], and (c) kinetic energy [LA-ke (kdynes.cm/m2) = 0.5 * ρ * ACTEV * A2]. LA maximal volume and ACTEV were lower (42.9 ± 14.4 vs. 59.7 ± 14.7 cm3, P < 0.0001; 10.9 ± 3.3 vs. 13 ± 3.3 cm3, P = 0.0001, respectively), whereas ACTEF (%) was higher (36.3 ± 7 vs. 29.3 ± 7.6 cm3, P < 0.0001) in controls than HF. LAEF, LAEFm, and LA-ke were lower in controls than HF (7.68 ± 5.1 vs. 10.16 ± 3.7 kdynes/m2, P = 0.006; 3.63 ± 2.05 vs. 5.02 ± 1.74 kdynes/m2, P = 0.0004; 2.41 ± 1.91 vs. 3.99 ± 2.1 kdynes.cm/m2, P < 0.0004, respectively).
Conclusion
Despite the decreased LA systolic shortening, overall LA systolic performance is augmented in chronic HF due to LA dilation.
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References
Stefanadis C, Dernellis J, Toutouzas P (2001) A clinical appraisal of left atrial function. Eur Heart J 22:22–36
Τripοskiadis F, Τrikas Α, Pitsavos C, Papadopoulos Ρ, Toutouzas Ρ (1992) Relation of exercise capacity in dilated cardiomyopathy to left atrial size and systolic function. Am J Cardiol 70:825–827
Sabharwal N, Cemin R, Rajan K, Hickman M, Lahiri A, Senior R (2004) Usefulness of left atrial volume as a predictor of mortality in patients with ischemic cardiomyopathy. Am J Cardiol 94:760–763
Rossi A, Cicoira M, Zanolla L et al (2002) Determinants and prognostic value of left atrial volume in patients with dilated cardiomyopathy. J Am Coll Cardiol 40:1425–1430
Matsuda Y, Toma Y, Matsuzaki M et al (1990) Change of left atrial systolic pressure waveform in relation to left ventricular end-diastolic pressure. Circulation 82:1659–667
Brennan EG, O’Hare NJ, Walsh MJ (1997) Correlation of end-diastolic pressure and myocardial elasticity with the transit time of the left atrial pressure wave (A-Ar interval). J Am Soc Echocardiogr 10:293–299
McKee PA, Castelli WP, McNamara PM, Kannel WB (1971) The natural history of congestive heart failure; The Framingham Study. N Engl J Med 285:1441–1446
Teichholz LE, Kreulen T, Herman MV, Gorlin R (1976) Problems in echocardiographic volume determinations: echocardiographic angiographic correlations in the presence or absence of asynergy. Am J Cardiol 37:7–11
Ren JF, Kotler MN, DePace NL et al (1983) Two-dimensional echocardiographic determination of left atrial emptying volume: a noninvasive index in quantifying the degree of nonrheumatic mitral regurgitation. J Am Coll Cardiol 2:729–736
Manning MJ, Silverman DI, Κatz SE, Douglas PS (1993) Atrial ejection force: a noninvasive assessment of left atrial systolic function. J Am Coll Cardiol 22:221–225
Triposkiadis F, Tentolouris K, Androulakis A et al (1995) Left atrial mechanical function in the healthy elderly: new insights from a combined assessment of changes in atrial volume and transmitral flow velocity. J Am Soc Echocardiogr 8:801–809
Stefanadis C, Dernellis J, Lambrou S et al (1998) Left atrial energy in normal subjects, in patients with symptomatic mitral stenosis and in patients with advanced heart failure. Am J Cardiol 82:1220–1223
Bland JM, Altman DG (1999) Measuring agreement in method comparison studies. Stat Methods Med Res 8:135–160
Linderer T, Chatterjee K, Parmley WW, Sievers RE, Glantz SA, Tyberg JV (1983) Influence of atrial systole on the Frank-Starling relation and the end-diastolic pressure-diameter relation of the left ventricle. Circulation 67:1045–1053
Hoit BD, Shao Y, Gabel M, Walsh RA (1995) Left atrial mechanical and biochemical adaptation to pacing induced heart failure. Cardiovasc Res 29:469–474
Dernellis JM, Panaretou MP (2003) Effects of digoxin on left atrial function in heart failure. Heart 89:1308–1315
Sasaki T, Kubo T, Miyamoto T et al (2002) Left atrial function preserves pulmonary circulatory pressure during pacing-tachycardia and contributes to exercise capacity in patients with idiopathic dilated cardiomyopathy in sinus rhythm, whose exercise is limited by dyspnea. Circ J 66:937–942
Braunwald E, Frahm CJ (1961) Studies on Starling’s law of the heart. IV. Observations on the hemodynamic functions of the left atrium in man. Circulation 24:633–642
Sanada Η, Shimizu Μ, Shimizu Κ, Κita Υ, Sugίhara Ν, Takeda R (1991) Left atrial afterload mismatch in hypertrophic cardiomyopathy. Am J Cardiol 68:1049–1054
Triposkiadis F, Moyssakis I, Hadjinikolaou L et al (1999) Left atrial systolic function is depressed in idiopathic and preserved in ischemic dilated cardiomyopathy. Eur J Cιin Invest 29:905–912
Legget ME, Bashein G, McDonald JA et al (1998) Three-dimensional measurement of the mitral annulus by multiplane transesophageal echocardiography: in vitro validation and in vivo demonstration. J Am Soc Echocardiogr 11:188–200
Kaplan SR, Bashein G, Sheehan FH et al (2000) Three-dimensional echocardiographic assessment of annular shape changes in the normal and regurgitant mitral valve. Am Heart J 139:378–387
Ormiston JA, Shah PM, Tei C, Wong M (1981) Size and motion of the mitral valve annulus in man. I. A two-dimensional echocardiographic method and findings in normal subjects. Circulation 64:113–120
Jenkins C, Bricknell K, Marwick TH (2005) Use of real-time three-dimensional echocardiography to measure left atrial volume: comparison with other echocardiographic techniques. J Am Soc Echocardiogr 18:991–997
Pritchett AM, Jacobsen SJ, Mahoney DW, Rodeheffer RJ, Bailey KR, Redfield MM (2003) Left atrial volume as an index of left atrial size: a population-based study. J Am Coll Cardiol 41:1036–1043
Kircher B, Abbott JA, Pau S et al (1991) Left atrial volume determination by biplane two-dimensional echocardiography: validation by cine computed tomography. Am Heart J 121:864–871
Rodevan O, Bjornerheim R, Ljosland M, Maehle J, Smith HJ, Ihlen H (1999) Left atrial volumes assessed by three- and two-dimensional echocardiography compared to MRI estimates. Int J Card Imaging 15:397–410
Bowman AW, Kovacs SJ (2004) Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart: a combined MRI-echocardiographic study. Am J Physiol Heart Circ Physiol 286:H2416–H2424
Henein MY, Gibson DG. (1999) Long axis function in disease. Heart 81:229–231
de Marchi SF, Bodenmuller M, Lai DL, Seiler C (2001) Pulmonary venous flow velocity patterns in 404 individuals without cardiovascular disease. Heart 85:23–29
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Triposkiadis, F., Harbas, C., Sitafidis, G. et al. Echocardiographic assessment of left atrial ejection force and kinetic energy in chronic heart failure. Int J Cardiovasc Imaging 24, 15–22 (2008). https://doi.org/10.1007/s10554-007-9219-7
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DOI: https://doi.org/10.1007/s10554-007-9219-7