Skip to main content

Advertisement

Log in

Dynamic left ventricular outflow tract obstruction induced by dobutamine stress echocardiography leading to myocardial ischemia and infarction

  • Case report
  • Published:
The International Journal of Cardiovascular Imaging Aims and scope Submit manuscript

Abstract

Left ventricular outflow tract (LVOT) obstruction occurring during dobutamine stress echocardiography (DSE) occurs in approximately 15–20% of patients undergoing DSE. The clinical significance and mechanism of LVOT obstruction has been debated, but is now generally felt to result from the pharmacological effects of dobutamine in increasing inotropy and causing peripheral vasodilation. It must be realized that in rare instances, ischemia may occur and lead to wall motion abnormalities and eventually myocardial infarction. We present the case of a 70-year-old asymptomatic woman who underwent a routine pre-operative cardiac stress evaluation and was found to develop a dynamic outflow tract obstruction leading to myocardial ischemia and infarction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Cortigiani L, Picano E, Coletta C, Chiarella F, Mathias W, Gandolfo N, De Alacantra M, Mazzoni V, Gensini GF, Landi P (2001) Safety, feasibility and prognostic implications of pharmacologic stress echocardiography in 1482 patients evaluated in an ambulatory setting. Am Heart J 141:621–629

    Article  PubMed  CAS  Google Scholar 

  2. Luria D, Klutstein W, Rosenmann D, Shaheen J, Sergey S, Tzivoni D (1999) Prevalence and significance of left ventricular outflow gradient during dobutamine echocardiography. Eur Heart J 20:386–392

    Article  PubMed  CAS  Google Scholar 

  3. Pellikka PA, Oh JK, Bailey KR, Nicholas BA, Monahan KH, Tajik J (1992) Dynamic intraventricular obstruction during dobutamine stress echocardiography. Circulation 86:1429–1432

    PubMed  CAS  Google Scholar 

  4. Hansen A, Hardt SE, Pekrul I, Filusch A, Bekeredjian R, Kuecherer HF (2003). Detection of acute myocardial ischemia during pharmacological stress in graded coronary artery stenosis: analysis of left ventricular asynchrony using Fourier phase imaging in pigs. Int J Cardiovasc Imaging 19(2):107–115

    Article  PubMed  Google Scholar 

  5. Kawano H, Fujii H, Motoyama T, Kugiyama K, Ogawa H, Yasue H (2005) Myocardial Ischemia due to coronary artery spasm during dobutamine stress echocardiography. Am J Cardiol 85:26–30

    Article  Google Scholar 

  6. Williams RS, Bishop T (1981) Selectivity of dobutamine for adrenergic receptor subtype. J Clin Invest 67:1703–1711

    Article  PubMed  CAS  Google Scholar 

  7. Tuttle RR, Mills J (1975) Dobutamine: development of a new catecholamine to selectivity increases cardiac contractility. Circ Res 36:185–196

    PubMed  CAS  Google Scholar 

  8. Yasue H, Omote S, Takizawa A, Nagao M, Miwa K, Tanaka S (1979) Circadian variation of exercise capacity in patients with Prinzmetal’s variant angina: role of exercise-induced coronary arterial spasm.Circulation 59:938–948

    PubMed  CAS  Google Scholar 

  9. Crouse LJ, Cheirif J, Hanly DE et al. (1993) Opacification and border delineation improvement in patients with suboptimal endocardial border definition in routine echocardiography: results of the phase III Albunex Multicenter Trial. J Am Coll Cardiol 22:1494–1500

    PubMed  CAS  Google Scholar 

  10. Stewart MJ (2003) Contrast echocardiography. Heart 89(3):342–8

    Article  PubMed  Google Scholar 

  11. Marcovitz P, Bach D, Mathias W, Shayna V, Armstrong W (1993) Paradoxic hypotension during dobutamine stress echocardiography: clinical and diagnostic implications. J Am Coll Cardiol 21:1080–1086

    Article  PubMed  CAS  Google Scholar 

  12. Weissman N, Nidorf S, Weyman A, Picard M (1995) Effect of hydration on cavity obliteration during dobutamine stress echocardiography. Clin Cardiol 18:17–20

    Article  PubMed  CAS  Google Scholar 

  13. Picano E, Mathias W, Pingitore A, Bigi R, Previtali M (1994) Safety and tolerability of dobutamine-atropine stress echocardiography: a prospective, multicentre study. Lancet 344:1190–1192

    Article  PubMed  CAS  Google Scholar 

  14. Meimoun P, Benali T, Sayah S, Luycx-Bore A, Maitre B, Tribouilloy C (2005) Significance of Systolic Anterior Motion of the Mitral Valve During Dobutamine Stress Echocardiography. J Am Soc Echocardiogr 18:49–56

    Article  PubMed  Google Scholar 

  15. Sharma R, Pellerin D, Gaze DC, Mehta RL, Gregson H, Streather CP, Collinson PO, Brecker SJ (2006) Dynamic left ventricular obstruction: a potential cause of angina in end stage renal disease (IJCA-g-0979). Int J Cardiol (In Press)

  16. Dawn B, Paliwal VS, Raza ST, Mastali K, Longaker RA, Stoddard MF (2005) Left ventricular outflow tract obstruction provoked during dobutamine stress echocardiography predicts future chest pain, syncope, and near syncope. Am Heart J 149(5):908–916

    Article  PubMed  Google Scholar 

  17. Maraj S, Jacobs LE, Maraj R, Contreras R, Rerkpattanapipat P, Malik TA, Manzarbeitia C, Munoz S, Rothstein K, Kotler MN (2004) Inducible left ventricular outflow tract gradient during dobutamine stress echocardiography: an association with intraoperative hypotension but not a contraindication to liver transplantation. Echocardiography 21(8):681–685

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David Rosman.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Makaryus, A.N., Meraj, P. & Rosman, D. Dynamic left ventricular outflow tract obstruction induced by dobutamine stress echocardiography leading to myocardial ischemia and infarction. Int J Cardiovasc Imaging 22, 763–769 (2006). https://doi.org/10.1007/s10554-006-9102-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10554-006-9102-y

Keywords

Navigation