Abstract
Objectives
The purpose of this study was to assess in vivo the reproducibility of tissue characterization using spectral analysis of intravascular ultrasound (IVUS) radiofrequency data (IVUS-VH).
Background
Despite the need for reproducibility data to design longitudinal studies, such information remains unexplored.
Methods and results
IVUS-VH (Volcano Corp., Rancho Cordova, USA) was performed in patients referred for elective percutaneous intervention and in whom a non-intervened vessel was judged suitable for a safe IVUS interrogation. The IVUS catheters used were commercially available catheters (20 MHz, Volcano Corp., Rancho Cordova, USA). Following IVUS-VH acquisition, and after the disengagement and re-engagement of the guiding catheter, an additional acquisition was performed using a new IVUS catheter. Fifteen patients with 16 non-significant lesions were assessed by 2 independent observers. The relative inter-catheter differences regarding geometrical measurements were negligible for both observers. The inter-catheter relative difference in plaque cross-sectional area (CSA) was 3.2% for observer 1 and 0.5% for observer 2. The limits of agreement for (observer 1 measurements) lumen, vessel, plaque and plaque burden measurements were 0.82, −1.10 mm2; 0.80, −0.66 mm2; 1.08, −0.66 mm2; and 5.83, −3.89%; respectively. Limits of agreement for calcium, fibrous, fibrolipidic and necrotic core CSA measurements were 0.22, −0.25 mm2; 1.02, −0.71 mm2; 0.61, −0.65 mm2; and 0.43, −0.38 mm2 respectively. Regarding the inter-observer agreement, the limits of agreement for lumen, vessel, plaque and plaque burden measurements were 2.61, −2.09 mm2; 2.20–3.03 mm2; 1.70, −3.04 mm2; and 9.16, −16.41%; respectively, and for calcium, fibrous, fibrolipidic and necrotic core measurements of 0.08, −0.09 mm2; 0.89, −1.28 mm2; 0.74, −1.06 mm2; and 0.16, −0.20 mm2; respectively.
Conclusions
The present study demonstrates that the geometrical and compositional output of IVUS-VH is acceptably reproducible.
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We declare that G. Rodriguez-Granillo has received a research grant from Volcano Corp. No other author has a conflict of interest to disclose.
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Rodriguez-Granillo, G.A., Vaina, S., García-García, H.M. et al. Reproducibility of intravascular ultrasound radiofrequency data analysis: implications for the design of longitudinal studies. Int J Cardiovasc Imaging 22, 621–631 (2006). https://doi.org/10.1007/s10554-006-9080-0
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DOI: https://doi.org/10.1007/s10554-006-9080-0