Abstract
Combined activated protein C resistance and dilated cardiomyopathy result in a multiplicative effect on thrombosis risk. However, it is not known that whether there is an association with activated protein C resistance and dilated cardiomyopathy. We present a 18-year-old patient with dilated cardiomyopathy, who exhibited multichamber intracardiac thrombi on transthoracic echocardiography associated with activated protein C resistance. Our cases emphasizes that patients with cardiac thrombosis before adulthood should be screened for an underlying coagulation abnormality besides underlying cardiac disorders.
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References
PM Ridker, Inherited risk factors for venous thromboembolism: implications for clinical practice. Clin Cornerstone 4 (2002) 18-30
CT Esmon, The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 264 (1989) 4743-4746
B Dahlback, M Carlsson and PJ Svensson, Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 90 (1993) 1004-1008
RM Bertina, BP Koeleman and T Koster, Mutation in blood coagulation factor V associated with resistance to activated protein. C Nature 369 (1994) 64-67
JH Griffin, B Evatt, C Wideman and JA Fernandez, Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood 82 (1993) 1989-1993
T Koster, FR Rosendaal, H Ronde de, E Briet, JP Vandenbroucke and RM Bertina, Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 342 (1993) 1503-1506
K Middendorf, P Gohring, TY Huehns, D Seidel, G Steinbeck and S Nikol, Prevalence of resistance against activated protein C resulting from factor V Leiden is significantly increased in myocardial infarction: investigation of 507 patients with myocardial infarction. Am Heart J 147 (2004) 897-904
B Dorweiler, A Neufang, W Kasper-Koenig, H Schinzel, W Schmiedt and H Oelert, Arterial embolism to the upper extremity in a patient with factor V Leiden mutation (APC resistance) – a case report and review of the literature. Angiology 54 (2003) 125-130
GY Lip and CR Gibbs, Does heart failure confer a hypercoagulable state? Virchow’s triad revisited. J Am Coll Cardiol 33 (1999) 1424-1426
PM Ridker, RJ Glynn, JP Miletich, SZ Goldhaber, MJ Stampfer and CH Hennekens, Age-specific incidence rates of venous thromboembolism among heterozygous carriers of factor V Leiden mutation. Ann Intern Med 126 (1997) 528-531
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Yetim, M., Ozeke, O., Deveci, B. et al. Multichamber Intracardiac Thrombi Associated with Activated Protein C Resistance in a Patient with Dilated Cardiomyopathy. Int J Cardiovasc Imaging 22, 59–61 (2006). https://doi.org/10.1007/s10554-005-7437-4
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DOI: https://doi.org/10.1007/s10554-005-7437-4