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A Comparison of CH3-DTPA-GD (NMS60) and GD-DTPA for Evaluation of Acute Myocardial Ischemia

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Abstract

Purpose: Our objective was to evaluate the use of a new medium weight MRI contrast agent, NMS60 (a␣synthetic oligomeric Gd-complex containing three Gd3+ atoms, molecular weight 2158 Da) compared to gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) in a pig myocardial ischemia model. Materials: We used 13 male white hybrid pigs. Animals were scanned in the acute phase 2–3 h after the onset of myocardial ischemia. Scans were acquired on a 1.5T GE Signa with dynamic T1-weighted imaging during a bolus injection of 0.1 mmol(gd)/kg of either NMS60 or Gd-DTPA, 2D CINE at 5 min after injection, and T1-weighted spin-echo imaging up to 60 min. Results: The postcontrast CINE scans showed improved contrast-to-noise ratio after NMS60 injection, compared to Gd-DTPA. There was significantly greater enhancement with NMS60 in both normal myocardium and in the ischemic lesion on T1-weighted spin-echo scans up to 60 min after injection. The dose ranging study shows a 24% greater enhancement with NMS60 compared to Gd-DTPA. Discussion: This new medium weighted contrast agent offers improved enhancement for cardiac MRI, compared to Gd-DTPA, with similar washout kinetics and lower toxicity, and may prove useful for better detection of myocardial ischemia as well as delayed or hyperenhancement after reperfusion.

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Authors and Affiliations

  1. Lucas MRS/I Center, Department of Radiology, Stanford University, RM. 2301, Building 149, 13th Street, Stanford,Charlestown, MA 02129, California, USA

    H. E. D’Arceuil, A. J. de Crespigny, L. Pelc, D. Howard & M. E. Moseley

  2. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA

    H. E. D’Arceuil & A. J. de Crespigny

  3. Clinical Development Department, Nihon Medi-Physics Co. Ltd., Tokyo, Japan

    S. Seri

  4. Research Center, Nihon Medi-Physics Co. Ltd., Chiba, Japan

    Y. Hashiguchi & A. Nakatani

Authors
  1. H. E. D’Arceuil
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  2. A. J. de Crespigny
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  3. L. Pelc
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  4. D. Howard
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  5. S. Seri
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  6. Y. Hashiguchi
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  8. M. E. Moseley
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Correspondence to H. E. D’Arceuil.

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D’Arceuil, H.E., de Crespigny, A.J., Pelc, L. et al. A Comparison of CH3-DTPA-GD (NMS60) and GD-DTPA for Evaluation of Acute Myocardial Ischemia. Int J Cardiovasc Imaging 21, 539–547 (2005). https://doi.org/10.1007/s10554-005-2103-4

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  • DOI: https://doi.org/10.1007/s10554-005-2103-4

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