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Volume measurements in nuclear medicine gated SPECT and 4D echocardiography: validation using a dynamic cardiac phantom

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Abstract

Purpose: A dynamic cardiac phantom was used as a reference to compare volumes measured with gated SPECT and 4D echocardiography. Material and Methods: Gated SPECT data were acquired with a standard single-head gamma camera, and the volume reconstructions were carried out using the Mirage software by Segami. 4D echocardiography used a new prototype of rotating scan head to acquire ultrasound images during a cardiac cycle, used to reconstruct the volume deformations as a function of time. End-diastolic volume, end-systolic volume, and ejection fraction were measured using both gated SPECT and 4D echocardiography. Results: The results obtained showed a good correlation between volumes measured with the two modalities, but a slight overestimation of volumes with gated SPECT. The influence of filtering and pixel size parameters on the measured volumes was quantified for gated SPECT, in order to correct the overestimation. Conclusion: The agreement between gated SPECT (after correction) and 4D echocardiography confirmed the relevance of the comparisons. This study was an initial step before conducting clinical trials to compare exhaustively left ventricular volumes obtained with the two modalities.

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Abbreviations

2D:

bi-dimensional

3D:

three-dimensional

4D:

four-dimensional

Bq:

Bequerel

ECG:

electrocardiogram

eV:

electron volt

LV:

left ventricle

NM:

nuclear medicine

QGS:

quantitative gated SPECT

SPECT:

single-photon emission computed tomography

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Authors and Affiliations

  1. Service de Médecine Nucléaire, Centre Hospitalier Régional d’ Orléans (CHRO), 14 Avenue de 1’Hôpital, BP 6709, 45067, Orléans Cedex 2, France

    Dominique Debrun & Fabienne Thérain

  2. Service de Cardiologie, Centre Hospitalier Régional d’ Orléans (CHRQ), 14 Avenue de 1’ Hôpital, BP 6709, 45067, Orléans Cedex 2, France

    Long-Dang Nguyen

  3. Laboratoire d’ Electronique Signaux Images (LESI), Université d’ Orléans, 12 rue de Blois, BP 6744, 45067, Orléans Cedex 2, France

    Christophe P. Léger

  4. Academic Medical Centre, Department of Nuclear Medicine, University of Amsterdam, P.O. Box 22700, 1100, DE Amsterdam, The Netherlands

    Jacco J. N. Visser

Authors
  1. Dominique Debrun
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  2. Fabienne Thérain
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  3. Long-Dang Nguyen
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  4. Christophe P. Léger
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  5. Jacco J. N. Visser
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Correspondence to Christophe P. Léger.

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Debrun, D., Thérain, F., Nguyen, LD. et al. Volume measurements in nuclear medicine gated SPECT and 4D echocardiography: validation using a dynamic cardiac phantom. Int J Cardiovasc Imaging 21, 239–247 (2005). https://doi.org/10.1007/s10554-004-4014-1

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  • DOI: https://doi.org/10.1007/s10554-004-4014-1

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