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Cine and tagged magnetic resonance imaging in short-term stunned versus necrotic myocardium

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Abstract

We investigated the potential of Cine and 2D Tagged Cardiac Magnetic Resonance (CMR) Imaging to distinguish stunned from necrotic left ventricular (LV) myocardium in the early postischemic phase in an open-chest animal model (N=12). Reversible and permanent occlusion of the LAD coronary artery resulted in global LV dysfunction in both groups without significant differences. LAD perfused segments revealed significant higher values for end systolic wall thickening (ESWT) and percentual systolic wall thickening in animals with stunned myocardium. Analysis of strain parameters showed significant regional differences (maximal principal strain λ1, deviation angle β) between postischemic and remote myocardium within both groups, however results were not significantly different comparing animals with stunned myocardium to animals with myocardial necrosis. In conclusion, at rest neither global LV functional nor regional strain parameters derived from Cine and 2D Tagged CMR Imaging can distinguish animals with short-term stunned myocardium from respective animals with necrotic myocardium. Diagnostic value of ESWT is limited due to the spatial resolution of the gradient-echo sequence used.

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Authors and Affiliations

  1. Department of Clinical Radiology, University of Muenster, Albert-Schweitzer-Strase 33, D-48149, Muenster, Germany

    Kai Uwe Juergens, Peter Reimer, Bernd Tombach, Christoph Bremer, Bernhard Renger & Walter Heindel

  2. Department of Radiology, Städtisches Klinikum Karlsruhe, Moltkestraße 90, D-76133, Karlsruhe

    Peter Reimer

  3. Department of Anesthesiology and Intensive Care Medicine, University of Muenster, Albert-Schweitzer-Straße 33, D-48149, Muenster

    Thomas Peter Weber & Hugo Van Aken

  4. Department of Diagnostic Radiology, Technical University Munich, Ismaninger Straße 22, D-81675, Munich, Germany

    Bernhard Renger

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  1. Kai Uwe Juergens
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  2. Peter Reimer
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  3. Thomas Peter Weber
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Correspondence to Kai Uwe Juergens.

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Supported by a grant from the Interdisciplinary Center of Clinical Research (IZKF; B1, BMBF-01KS 9604).

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Juergens, K.U., Reimer, P., Weber, T.P. et al. Cine and tagged magnetic resonance imaging in short-term stunned versus necrotic myocardium. Int J Cardiovasc Imaging 21, 271–282 (2005). https://doi.org/10.1007/s10554-004-2459-x

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