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Geographic variation and association of risk factors with incidence of colorectal cancer at small-area level

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Abstract

Purpose

Examining spatial distribution of colorectal cancer (CRC) incidence or mortality is helpful for developing cancer control and prevention programs or for generating hypotheses. Such an investigation involves describing the spatial variation of risk factors for CRC and identifying hotspots. The aim of this study is to identify county-level risk factors that may be associated with the incidence of CRC and to map hotspots for CRC in Florida.

Methods

County-level CRC cases, recorded in 2018, were obtained from the Florida Department of Health, Division of Public Health Statistics & Performance Management (DPHSM). Data on county-level risk factors were also obtained from the same source. We used Bayesian spatial models for relative incidence rates and produced posterior predictive that indicates excess risk (hotspots) for CRC.

Results

The county-level unadjusted incidence rates range from .462 to 3.142. After fitting a Bayesian spatial model to the data, the results show that a decreasing risk of CRC is strongly associated with an increasing median income, higher percentage of Black population, and higher percentage of sedentary life at county level. Using exceedance probability, it is also observed that there are clustering and hotspots of high CRC incidence rates in Charlotte County in South Florida, Hernando, Sumter and Seminole counties in central Florida and Union and Washington counties in north Florida.

Conclusion

Among few county-level variables that significantly explained the spatial variation of CRC, income disparity may need more attention for resource allocation and developing preventive intervention in high-risk areas for CRC.

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Data availability

The datasets were obtained from publicly archived located at: https://www.flhealthcharts.gov/ChartsReports/rdPage.aspx?rdReport=NonVitalInd.Dataviewer&cid=0445.

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The author declares that no funds were received during the preparation of this manuscript.

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  1. College of Public Health, University of South Florida, Tampa, USA

    Getachew A. Dagne

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  1. Getachew A. Dagne
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Correspondence to Getachew A. Dagne.

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Dagne, G.A. Geographic variation and association of risk factors with incidence of colorectal cancer at small-area level. Cancer Causes Control 33, 1155–1160 (2022). https://doi.org/10.1007/s10552-022-01607-5

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  • DOI: https://doi.org/10.1007/s10552-022-01607-5

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