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Coffee intake and trace element blood concentrations in association with renal cell cancer among smokers

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Abstract

Purpose

To determine whether higher coffee intake may reduce the risk of renal cell cancer (RCC) associated with lead (Pb) and other heavy metals with known renal toxicity. Methods: We conducted a nested case–control study of male smokers (136 RCC cases and 304 controls) within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Cases diagnosed with RCC at 5 or more years following cohort enrollment were matched to controls on age (± 7 years) and whole blood draw date (± 30 days). Conditional logistic regression (using two-sided tests) was used to test for main effects and additive models of effect modification. Results: After a mean follow-up of 16.3 years, coffee consumption was not significantly associated with renal cell cancer risk, when adjusting for blood concentrations of Cd, Hg, and Pb and RCC risk factors (age, smoking, BMI, and systolic blood pressure) (p-trend, 0.134). The association with above median blood Pb and RCC (HR = 1.69, 95% CI 1.06, 2.85) appeared to be modified by coffee consumption, such that RCC risk among individuals with both increased coffee intake and higher blood lead concentration were more than threefold higher RCC risk (HR = 3.40, 95% CI 1.62, 7.13; p-trend, 0.003). Conclusion: Contrary to our initial hypothesis, this study suggests that heavy coffee consumption may increase the previously identified association between higher circulating lead (Pb) concentrations and increased RCC risk. Improved assessment of exposure, including potential trace element contaminants in coffee, is needed.

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Data availability

Data are available upon request and proposal approval from Demetrius Albanes, MD National Cancer Institute.

References

  1. Al-Bayati O, Hasan A, Pruthi D, Kaushik D, Liss MA (2019) Systematic review of modifiable risk factors for kidney cancer. Urol Oncol Semin Orig Investig 37:359–371. https://doi.org/10.1016/j.urolonc.2018.12.008

    Article  Google Scholar 

  2. Boffetta P, Fontana L, Stewart P, Zaridze D, Szeszenia-dabrowska N, Janout V, Bencko V, Foretova L, Jinga V, Matveev V, Kollarova H, Ferro G, Chow W, Rothman N, Van BD, Karami S, Brennan P, Moore LE (2011) Occupational exposure to arsenic, cadmium, chromium, lead and nickel, and renal cell carcinoma: a case-control study from Central and Eastern Europe. Occup Env Med 68:723–728. https://doi.org/10.1136/oem.2010.056341

    Article  CAS  Google Scholar 

  3. Southard EB, Roff A, Fortugno T, Richie JP, Kaag M, Chinchilli VM, Virtamo J, Albanes D, Weinstein S, Wilson RT (2012) Lead, calcium uptake, and related genetic variants in association with renal cell carcinoma risk in a cohort of male finnish smokers. Cancer Epidemiol Biomarkers Prev 21:191–201. https://doi.org/10.1158/1055-9965.EPI-11-0670

    Article  CAS  PubMed  Google Scholar 

  4. Wong MCS, Goggins WB, Yip BHK, Fung FDH, Leung C, Fang Y, Wong SYS, Ng CF (2017) Incidence and mortality of kidney cancer : temporal patterns and global trends in 39 countries. Sci Rep 7:1–10. https://doi.org/10.1038/s41598-017-15922-4

    Article  CAS  Google Scholar 

  5. de Melo Pereira GV, de Carvalho Neto DP, Magalhães Júnior AI, do Prado FG, Pagnoncelli MGB, Karp SG, Soccol CR (2020) Chapter Three - Chemical composition and health properties of coffee and coffee by-products, In: Toldrá F (ed) Advances in Food and Nutrition Research. Academic Press, Cambridge, MA, pp 65–96. https://doi.org/10.1016/bs.afnr.2019.10.002

  6. Pohl P, Stelmach E, Welna M, Szymczycha-Madeja A (2013) Determination of the elemental composition of coffee using instrumental methods. Food Anal Methods 6:598–613. https://doi.org/10.1007/s12161-012-9467-6

    Article  Google Scholar 

  7. Jeszka-Skowron M, Zgoła-Grześkowiak A, Grześkowiak T (2015) Analytical methods applied for the characterization and the determination of bioactive compounds in coffee. Eur Food Res Technol 240:19–31. https://doi.org/10.1007/s00217-014-2356-z

    Article  CAS  Google Scholar 

  8. Priftis A, Stagos D, Konstantinopoulos K, Tsitsimpikou C, Spandidos DA, Tsatsakis AM, Tzatzarakis MN, Kouretas D (2015) Comparison of antioxidant activity between green and roasted coffee beans using molecular methods. Mol Med Rep 12:7293–7302. https://doi.org/10.3892/mmr.2015.4377

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Fukushima Y, Tashiro T, Kumagai A, Ohyanagi H, Horiuchi T, Kondo K (2014) Coffee and beverages are the major contributors to polyphenol consumption from food and beverages in Japanese middle-aged women. Journal of nutritional science. J Nutr Sci 3:1–10. https://doi.org/10.1017/jns.2014.19

    Article  CAS  Google Scholar 

  10. Huang Q, Braffett BH, Simmens SJ, Young HA, Ogden CL (2020) Dietary polyphenol intake in US adults and 10-year trends: 2007–2016. J Acad Nutr Diet 120:1821–1833. https://doi.org/10.1016/j.jand.2020.06.016

    Article  PubMed  Google Scholar 

  11. Wilson RT, Wang J, Chinchilli V, Richie JP, Virtamo J, Moore E, Albanes D (2009) Original contribution fish, vitamin D, and flavonoids in relation to renal cell cancer among smokers. Am J Epidemiol 170:717–729. https://doi.org/10.1093/aje/kwp178

    Article  PubMed  PubMed Central  Google Scholar 

  12. Bosetti C, Rossi M, Mclaughlin JK, Negri E, Talamini R, Lagiou P, Montella M, Ramazzotti V, Franceschi S, Lavecchia C (2007) Flavonoids and the risk of renal cell carcinoma. Cancer Epidemiol Biomarkers Prev 16:98–102. https://doi.org/10.1158/1055-9965.EPI-06-0769

    Article  CAS  PubMed  Google Scholar 

  13. Tej GNVC, Nayak PK (2018) Mechanistic considerations in chemotherapeutic activity of caffeine. Biomed Pharmacother 105:312–319. https://doi.org/10.1016/j.biopha.2018.05.144

    Article  CAS  PubMed  Google Scholar 

  14. Chang YL, Hsu YJ, Chen Y, Wang YW, Huang SM (2017) Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines. Oncotarget. 8(60):101461–101474. https://doi.org/10.18632/oncotarget.21464

  15. Poole R, Kennedy OJ, Roderick P (2017) Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ 359:j5024. https://doi.org/10.1136/bmj.j5024

    Article  PubMed  PubMed Central  Google Scholar 

  16. Moeenfard M, Alves A (2020) New trends in coffee diterpenes research from technological to health aspects. Food Res Int 134:109207. https://doi.org/10.1016/j.foodres.2020.109207

    Article  CAS  PubMed  Google Scholar 

  17. Brice CF, Smith AP (2002) Factors associated with caffeine consumption. Int J Food Sci Nutr 53:55–64. https://doi.org/10.1080/09637480120057000

    Article  PubMed  Google Scholar 

  18. Hewlett P, Smith A (2006) Correlates of daily caffeine consumption. Appetite 46(1):97–99. https://doi.org/10.1016/j.appet.2005.10.004

    Article  PubMed  Google Scholar 

  19. Elhadad MA, Karavasiloglou N, Wulaningsih W, Tsilidis KK, Tzoulaki I, Patal CJ, Rohrmann S (2020) Metabolites, nutrients, and lifestyle factors in relation to coffee consumption: an environment-wide association study. Nutrients 12:1470. https://doi.org/10.3390/nu12051470

    Article  CAS  PubMed Central  Google Scholar 

  20. Sá I, Semedo M, Cunha ME (2016) Kidney cancer. Heavy metals as a risk factor. Porto Biomed J 1:25–28. https://doi.org/10.1016/j.pbj.2016.03.006

    Article  PubMed  PubMed Central  Google Scholar 

  21. Starug S (2018) Dietary cadmium intake and its effects on kidneys. Toxics 6:15. https://doi.org/10.3390/toxics6010015

    Article  CAS  Google Scholar 

  22. Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA (2017) The safety of ingested caffeine: a comprehensive review. Front Psychiatry 8:1–19. https://doi.org/10.3389/fpsyt.2017.00080

    Article  Google Scholar 

  23. Hashemian M, Sinha R, Murphy G, Weinstein SJ, Liao LM, Freedman ND, Abnet CC, Albanes D, Loftfield E (2019) Coffee and tea drinking and risk of cancer of the urinary tract in male smokers. Ann Epidemiol 34:33–39. https://doi.org/10.1016/j.annepidem.2019.03.014

    Article  PubMed  PubMed Central  Google Scholar 

  24. Reed W (2017) Coffee and coffee products in Finland. In: Finnpartnership. https://finnpartnership.fi/wp-content/uploads/2018/01/Coffee-in-Finland-2017-report-final.pdf. Accessed 2 Sep 2021

  25. Partanen T, Hemminki K, Vainio H, Kauppinen T (1995) Coffee ||Er in Finland. Prev Med 24:213–216. https://doi.org/10.1006/pmed.1995.1035

    Article  CAS  PubMed  Google Scholar 

  26. The ATBC cancer prevention study group (1994) The alpha-tocopherol, beta-carotene lung cancer prevention study : design, methods, participant characteristics, and compliance the atbc cancer prevention. Ann Epidemiol 4:1–10. https://doi.org/10.1016/1047-2797(94)90036-1

    Article  Google Scholar 

  27. Pietinen P, Hartman AM, Haapa E, Rasanen L, Haapakoski J, Palmgren J, Albanes D, Virtamo J, Huttunen JK (1988) Reproducibility and validity of dietary assessment instruments. Am J Epidemiol 128:667–676. https://doi.org/10.1093/oxfordjournals.aje.a115014

    Article  CAS  PubMed  Google Scholar 

  28. Mortensen ME, Wong LY, Osterloh JD (2011) Smoking status and urine cadmium above levels associated with subclinical renal effects in U.S. adults without chronic kidney disease. Int J Hyg Environ Health. 214(4):305–310. https://doi.org/10.1016/j.ijheh.2011.03.004

    Article  CAS  PubMed  Google Scholar 

  29. Ganguly K, Levänen B, Palmberg L, Åkesson A, Lindén A (2018) Cadmium in tobacco smokers: a neglected link to lung disease? Eur Respir Rev 27:170122. https://doi.org/10.1183/16000617.0122-2017

    Article  PubMed  Google Scholar 

  30. Wennberg M, Lundh T, Nilsson J, Bergdahl IA (2017) Time trends and exposure determinants of lead and cadmium in the adult population of northern Sweden 1990–2014. Environ Res 159:111–117. https://doi.org/10.1016/j.envres.2017.07.029

    Article  CAS  PubMed  Google Scholar 

  31. Antwi SO, Eckel-Passow JE, Diehl ND, Serie DJ, Custer KM, Arnold ML, Wu KJ, Cheville JC, Thiel DD, Leibovich BC, Parker AS (2019) Coffee consumption and risk of renal cell carcinoma. Physiol Behav 176:139–148. https://doi.org/10.1007/s10552-017-0913-z

    Article  Google Scholar 

  32. Nilsson LM, Johansson I, Lenner P, Lindahl B, Van Guelpen B, Maria L, Ingegerd N (2010) Consumption of filtered and boiled coffee and the risk of incident cancer : a prospective cohort study. Cancer Causes Control 21:1533–1544. https://doi.org/10.1007/s10552-010-9582-x

    Article  PubMed  Google Scholar 

  33. Yu MC, Mack TM, Hanisch R, Cicioni C, Henderson BE (1986) Cigarette smoking, obesity, diuretic use, and coffee consumption as risk factors for renal cell carcinoma. J Natl Cancer Instit 77:351–356. https://doi.org/10.1093/jnci/77.2.351

    Article  CAS  Google Scholar 

  34. Goodman MT, Morgenstern HAL, Wynder EL, Morgenstem H, Founda- ELWAH (1986) A case-control study of factors affecting the development of renal cell cancer. Am J Epidemiol 124:926–941. https://doi.org/10.1093/oxfordjournals.aje.a114482

    Article  CAS  PubMed  Google Scholar 

  35. Wijarnpreecha K, Thongprayoon C, Thamcharoen N, Panjawatanan P (2017) Association between coffee consumption and risk of renal cell carcinoma: a meta-analysis. Intern Med J 47:1422–1432. https://doi.org/10.1111/imj.13640

    Article  PubMed  Google Scholar 

  36. Jacobsen BK, Bjelke E, Kvale G, Heuch I (1986) Coffee drinking, mortality, and cancer incidence: results from a Norwegian prospective study. J Natl Cancer Inst 76:823–831. https://doi.org/10.1093/jnci/76.5.823

    Article  CAS  PubMed  Google Scholar 

  37. Jung EL, Hunter DJ, Spiegelman D, Adami HO, Bernstein L, Van Den Brandt PA, Buring JE, Cho E, English D, Folsom AR, Freudenheim JL, Gile GG, Giovannucci E, Horn-Ross PL, Leitzmann M, Marshall JR, Männistö S, McCullough ML, Miller AB, Parker AS, Pietinen P, Rodriguez C, Rohan TE, Schatzkin A, Scheuten LJ, Willett WC, Wolk A, Zhang SM, Smith-Warner SA (2007) Intakes of coffee, tea, milk, soda and juice and renal cell cancer in a pooled analysis of 13 prospective studies. Int J Cancer 121:2246–2253. https://doi.org/10.1002/ijc.22909

    Article  CAS  Google Scholar 

  38. Treur JL, Taylor AE, Ware JJ, Nivard MG, Neale MC, Mcmahon G, Hottenga J, Baselmans BML, Boomsma DI, Munafò MR, Vink JM (2016) Smoking and caffeine consumption: a genetic analysis of their association. Addict Biol 22:1090–1102. https://doi.org/10.1111/adb.12391

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Dai Z-W, Cai K-D, Li F-R, Wu X-B, Chen G-C (2019) Association between coffee consumption and risk of bladder cancer in a meta-analysis of 16 prospective studies. Nutr Metab 16:1–11. https://doi.org/10.1186/s12986-019-0390-3

    Article  CAS  Google Scholar 

  40. Leviton A (2018) Biases inherent in studies of coffee consumption in early pregnancy and the risks of subsequent events. Nutrients 10:1152. https://doi.org/10.3390/nu10091152

    Article  CAS  PubMed Central  Google Scholar 

  41. Willson C (2018) The clinical toxicology of caffeine: A review and case study. Toxicol Reports 5:1140–1152. https://doi.org/10.1016/j.toxrep.2018.11.002

    Article  CAS  Google Scholar 

  42. Hemminki K, Jiang Y, Ma X, Yang K, Egevad L, Lindblad P (2002) Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients: relation to dietary and other factors. Carcinogenesis 23:809–815. https://doi.org/10.1093/carcin/23.5.809

    Article  CAS  PubMed  Google Scholar 

  43. Maher ER, Neumann HP, Richar S (2011) von Hippel – Lindau disease: a clinical and scientific review. Eur J Hum Genet 19:617–623. https://doi.org/10.1038/ejhg.2010.175

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Schmidt LS, Marston Linehan W (2018) Genetic predisposition to kidney cancer. Physiol Behav 176:139–148. https://doi.org/10.1053/j.seminoncol.2016.09.001.Genetic

    Article  Google Scholar 

  45. Van Dijk BAC, Schouten LJ, Oosterwijk E, Hulsbergen-Van De Kaa CA, Kiemeney LALM, Goldbohm RA, Schalken JA, Van Den Brandt PA (2006) Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma. Br J Cancer 95:374–377. https://doi.org/10.1038/sj.bjc.6603281

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Shiao Y, Rice JM, Anderson LM, Bhalchandra A, Hard GC (1997) von Hippel-lindau gene mutations in N -nitroso- dimethylamine-induced rat renal epithelial tumors. J Natl Cancer Inst 90:1720–1723. https://doi.org/10.1093/jnci/90.22.1720

    Article  Google Scholar 

  47. Rajamani K, Thirugnanasambandan SS (2018) Polyphenols from brown alga, Padina boergesenii (Allendar & Kraft) decelerates renal cancer growth involving cell cycle arrest and induction of apoptosis in renal carcinoma cells. Environmenal Toxicol 33:1135–1142. https://doi.org/10.1002/tox.22619

    Article  CAS  Google Scholar 

  48. Nkondjock A (2009) Coffee consumption and the risk of cancer: an overview. Cancer Lett 277:121–125. https://doi.org/10.1016/j.canlet.2008.08.022

    Article  CAS  PubMed  Google Scholar 

  49. Moeenfard M, Erny GL, Alves A (2016) Variability of some diterpene esters in coffee beverages as influenced by brewing procedures. J Food Sci Technol 53:3916–3927. https://doi.org/10.1007/s13197-016-2378-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Wang B, Guerrette Z, Whittaker MH, Ator J (2020) Derivation of a no significant risk level (NSRL) for acrylamide. Toxicol Lett 320:103–108. https://doi.org/10.1016/j.toxlet.2019.12.009

    Article  CAS  PubMed  Google Scholar 

  51. Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, Van Den Brandt PA (2008) Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer. Am J Clin Nutr 87:1428–1438. https://doi.org/10.1093/ajcn/87.5.1428

    Article  CAS  PubMed  Google Scholar 

  52. Gapstur SM, McCullough ML, Hodge RA, Um CY (2019) Dietary acrylamide is not associated with renal cell cancer risk in the CPS-II nutrition cohort. Cancer Epidemiol Biomarkers Prev 28:616–619. https://doi.org/10.1158/1055-9965.EPI-18-0909

    Article  PubMed  Google Scholar 

  53. Tilastokeskus [Central Statistical Office of Finland] (1990) Suomen tilastollinen vuosikirja 1990 [Statistical Yearbook of Finland 1990]. https://www.doria.fi/bitstream/10024/88766/1/xyti_stv_199000_1990_dig.pdf Accessed 26 Sep 2021

  54. Król K, Gantner M, Tatarak A, Hallmann E (2020) The content of polyphenols in coffee beans as roasting, origin and storage effect. Eur Food Res Technol 246:33–39. https://doi.org/10.1007/s00217-019-03388-9

    Article  CAS  Google Scholar 

  55. Esposito F, Fasano E, De Vivo A, Velotto S, Sarghini F, Cirillo T (2020) Processing effects on acrylamide content in roasted coffee production. Food Chem. 30(319):126550. https://doi.org/10.1016/j.foodchem.2020.126550

    Article  CAS  Google Scholar 

  56. Manley BJ, Hakimi AA (2016) Molecular profiling of renal cell carcinoma: building a bridge towards clinical impact. Curr Opin Urol 26:383–387. https://doi.org/10.1097/MOU.0000000000000307

    Article  PubMed  PubMed Central  Google Scholar 

  57. Clague J, Shao L, Lin J, Chang S, Zhu Y, Wang W, Wood CG (2009) Sensitivity to NNKOAc is associated with renal cancer risk. Carcinogenesis 30:706–710. https://doi.org/10.1093/carcin/bgp045

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Levallois P, Ayotte P, Maanen JMSV, Desrosiers T, Gingras S, Dallinga JW, Vermeer ITM, Zee J, Poirier G (2000) Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption. Food Chem Toxicol 38:1013–1019. https://doi.org/10.1016/s0278-6915(00)00089-2

    Article  CAS  PubMed  Google Scholar 

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Wu, H., Weinstein, S., Moore, L.E. et al. Coffee intake and trace element blood concentrations in association with renal cell cancer among smokers. Cancer Causes Control 33, 91–99 (2022). https://doi.org/10.1007/s10552-021-01505-2

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