Abstract
Purpose
Circulating inflammatory markers may predict prostate cancer (PC) outcomes. For example, a recent study showed that higher peripheral blood monocyte counts were associated with aggressive PC in Asian men undergoing radical prostatectomy (RP). Herein, we investigated whether peripheral monocyte count can predict long-term PC outcomes after RP in black and white men.
Methods
We retrospectively reviewed data on 2345 men undergoing RP from 2000 to 2017 at eight Veterans Affairs hospitals. Data on monocyte count within 6 and 12 months prior to surgery were collected. The study outcomes were biochemical recurrence (BCR), castration-resistant PC (CRPC), metastasis, all-cause mortality (ACM), and PC-specific morality (PCSM). Cox-proportional hazard models were used to assess the associations between pre-operative monocyte count and the above-mentioned outcomes accounting for confounders.
Results
Of 2345 RP patients, 972 (41%) were black and 1373 (59%) were white men. In multivariable analyses, we found no associations between monocyte count and BCR among all men (HR: 1.36, 95%CI 0.90–2.07) or when analyses were stratified by race (HR: 1.30, 95%CI 0.69–2.46, in black men; HR:1.33, 95%CI 0.76–02.33, in white men). Likewise, no overall or race-specific associations were found between monocyte count and CRPC, metastases, ACM, and PCSM, all p ≥ 0.15. Results were similar for monocyte count measured at 12 months prior to RP.
Conclusion
In black and white PC patients undergoing RP, peripheral monocyte count was not associated with long-term PC outcomes. Contrary to what was found in Asian populations, monocyte count was not associated with PC outcomes in this study.
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Funding
This study was supported by the National Institutes of Health; NIH 1R01CA231219-01 (WJA). Adriana Vidal was supported by a Research Scholar Grant, RSG-18–018-01—CPHPS, from the American Cancer Society.
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The study protocol was approved by the institutional review boards of the Durham VA Health System and Cedars-Sinai Medical Center. Consent was obtained at time of entry to the study.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Yirga, A., Oyekunle, T., Howard, L.E. et al. Monocyte counts and prostate cancer outcomes in white and black men: results from the SEARCH database. Cancer Causes Control 32, 189–197 (2021). https://doi.org/10.1007/s10552-020-01373-2
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DOI: https://doi.org/10.1007/s10552-020-01373-2