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Interplay between exercise and BMI; results from an equal access, racially diverse biopsy study

Cancer Causes & Control volume 30, pages 13–20 (2019)Cite this article

Abstract

Purpose

It is unclear if exercise and BMI interact to influence prostate cancer (PC) risk. We hypothesized BMI is linked with increased aggressive PC risk but this link will be attenuated with increased exercise.

Methods

Men undergoing prostate biopsy completed a questionnaire and metabolic equivalent (MET) hours of exercise was calculated. Of 695 men, 349 had PC; 161 low-grade, and 188 high-grade. We assessed the link between exercise and PC risk, high-grade PC (Gleason 7–10), and low-grade PC (Gleason 2–6) using logistic and multinomial logistic regression. Analysis was stratified by BMI. Link between BMI and PC risk and aggressive PC was similarly tested.

Results

On multivariable analysis, there was no link between exercise and PC diagnosis in the entire cohort (p trend = 0.18–0.71) or across BMI groups (p trend = 0.15–0.97). For the entire cohort, higher BMI was linked with increased risk of high-grade PC (OR 1.06, p = 0.008). When stratified by exercise groups, the trend for higher BMI and increased risk of high-grade PC remained (OR 1.03–1.15, p = 0.02–0.66). There were no interactions between exercise and BMI in predicting PC risk (all p ≥ 0.31).

Conclusions

Regardless of exercise, higher BMI was linked with higher risk of aggressive PC, while exercise was unrelated to PC risk. Confirmatory studies are needed.

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Author information

Affiliations

  1. Division of Urology, Veterans Affairs Medical Center, Durham, NC, USA

    Jamie Michael, Amanda De Hoedt & Stephen Freedland

  2. Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA

    Taofik Oyekunle & Lauren Howard

  3. Epidemiology and Environmental Epigenomics, North Carolina State University, Raleigh, NC, USA

    Catherine Hoyo

  4. Department of Biological and Biomedical Sciences, NC Central University, Durham, NC, USA

    Delores Grant

  5. Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Stephen Freedland

Authors
  1. Jamie Michael
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  2. Taofik Oyekunle
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  3. Lauren Howard
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  4. Amanda De Hoedt
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  5. Catherine Hoyo
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  6. Delores Grant
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  7. Stephen Freedland
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Corresponding author

Correspondence to Stephen Freedland.

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The authors declare no potential conflicts of interest.

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Michael, J., Oyekunle, T., Howard, L. et al. Interplay between exercise and BMI; results from an equal access, racially diverse biopsy study. Cancer Causes Control 30, 13–20 (2019). https://doi.org/10.1007/s10552-018-1104-2

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  • DOI: https://doi.org/10.1007/s10552-018-1104-2

Keywords

  • Prostate biopsy
  • Exercise
  • BMI
  • Veterans
  • Prostate cancer