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Habitual recreational physical activity is associated with significantly improved survival in cancer patients: evidence from the Roswell Park Data Bank and BioRepository

Abstract

Purpose

The association of recreational physical activity (RPA) with mortality is well established only for breast and colon cancers and few studies have evaluated relationships for exercising before and after diagnosis, across multiple disease sites. We examined the joint associations of pre- and post- diagnosis RPA with mortality in a cohort of 5,807 patients enrolled in the Data Bank and BioRepository at Roswell Park.

Methods

Patients were classified into one of four activity categories (habitually active, increased activity after diagnosis, decreased activity after diagnosis, habitually inactive). Cox proportional hazards models were used to estimate the associations of activity status with mortality.

Results

In comparison to patients who were habitually inactive, habitually active patients experienced a 39% decreased hazard of all-cause mortality (HR = 0.61, 95% CI 0.54–0.69) and a 36% decreased hazard of cancer-specific mortality (HR = 0.64, 95% CI 0.56–0.73). Previously inactive patients who began exercising after diagnosis experienced a 28% decreased hazard of all-cause (HR = 0.72, 95% CI 0.59–0.89) and cancer-specific mortality (HR = 0.72, 95% CI 0.57–0.91) in comparison to patients who remained inactive. Patients engaging in 3–4 sessions/week experienced the greatest survival advantages, but 1–2 sessions/week also yielded significant survival advantages in comparison to inactivity.

Conclusion

Low-to-moderate frequency pre- and post-diagnosis RPA was associated with significantly decreased mortality in patients diagnosed with a variety of malignancies. These observations solidify the clinical and public health importance of the message that some regular activity is better than inactivity, which is particularly encouraging, given that cancer survivors can be overwhelmed by current daily physical activity recommendations.

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Fig. 1

Abbreviations

RPA:

Recreational physical activity

MVPA:

Moderate-to-vigorous intensity physical activity

BMI:

Body mass index

DBBR:

Data Bank and BioRepository

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Funding

The study was funded in part by the Roswell Park Cancer Center Support Grant Shared Resource, supported by the National Cancer Institute Grant P30CA016056; Arinden Sen is supported by NIH R21CA194634 (AS).

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Corresponding author

Correspondence to Rikki A. Cannioto.

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Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

The research described herein was approved by Roswell Park’s IRB. Thus, all procedures and analyses performed were in accordance with the ethical standards of Roswell Park and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all participants included in the DBBR study.

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Cite this article

Cannioto, R.A., Dighe, S., Mahoney, M.C. et al. Habitual recreational physical activity is associated with significantly improved survival in cancer patients: evidence from the Roswell Park Data Bank and BioRepository. Cancer Causes Control 30, 1–12 (2019). https://doi.org/10.1007/s10552-018-1101-5

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Keywords

  • Physical activity
  • Survival
  • Mortality