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Cancer Causes & Control

, Volume 29, Issue 6, pp 581–588 | Cite as

Neutrophil, lymphocyte and platelet counts, and risk of prostate cancer outcomes in white and black men: results from the SEARCH database

  • Adriana C. Vidal
  • Lauren E. Howard
  • Amanda de Hoedt
  • Matthew R. Cooperberg
  • Christopher J. Kane
  • William J. Aronson
  • Martha K. Terris
  • Christopher L. Amling
  • Emanuela Taioli
  • Jay H. Fowke
  • Stephen J. Freedland
Original paper
  • 138 Downloads

Abstract

Purpose

Systemic inflammation, as measured by C-reactive protein, has been linked with poor prostate cancer (PC) outcomes, predominantly in white men. Whether other immune measures like white blood cell counts are correlated with PC progression and whether results vary by race is unknown. We examined whether complete blood count (CBC) parameters were associated with PC outcomes and whether these associations varied by race.

Methods

Analyses include 1,826 radical prostatectomy patients from six VA hospitals followed through medical record review for biochemical recurrence (BCR). Secondary outcomes included castration-resistant PC (CRPC), metastasis, all-cause mortality (ACM), and PC-specific mortality (PCSM). Cox-proportional hazards were used to assess the associations between pre-operative neutrophils, lymphocytes, platelets, neutrophil–lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) with each outcome. We used a Bonferroni-corrected p-value of 0.05/5 = 0.01 as the threshold for statistical significance.

Results

Of 1,826 men, 794 (43%) were black and 1,032 (57%) white. Neutrophil count (p < 0.001), NLR (p < 0.001), and PLR (p < 0.001) were significantly lower, while lymphocyte count (p < 0.001) was significantly higher in black versus white men. After adjusting for clinicopathological features, no CBC measures were significantly associated with BCR. There were no interactions between CBC and race in predicting BCR. Similarly, no CBC values were significantly associated with CRPC, metastases, or PCSM either among all men or when stratified by race. However, higher neutrophil count was associated with higher ACM risk in white men (p = 0.004).

Conclusion

Pre-operative CBC measures were not associated with PC outcomes in black or white men undergoing radical prostatectomy, except for neutrophils-positive association with risk of ACM in white men. Whether circulating immune cell markers provide insight to the pathophysiology of PC progression or adverse treatment outcomes requires further study.

Keywords

CBC Prostate cancer Radical prostatectomy 

Notes

Funding

Supported by National Institutes of Health; Grant numbers: K24 CA160653, NIH R01CA100938 (WJA), NIH Specialized Programs of Research Excellence Grant P50 CA92131-01A1 (WJA).

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Supplementary material

10552_2018_1031_MOESM1_ESM.docx (19 kb)
Supplementary material 1 (DOCX 19 KB)

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Adriana C. Vidal
    • 1
  • Lauren E. Howard
    • 2
    • 3
  • Amanda de Hoedt
    • 3
  • Matthew R. Cooperberg
    • 4
  • Christopher J. Kane
    • 5
  • William J. Aronson
    • 6
    • 7
  • Martha K. Terris
    • 8
    • 9
  • Christopher L. Amling
    • 10
  • Emanuela Taioli
    • 11
  • Jay H. Fowke
    • 12
  • Stephen J. Freedland
    • 1
    • 3
    • 13
  1. 1.Department of Surgery, Division of Urology, Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.Department of Biostatistics and BioinformaticsDuke University School of MedicineDurhamUSA
  3. 3.Surgery SectionDurham VA Medical CenterDurhamUSA
  4. 4.Department of UrologyUCSF Helen Diller Family Comprehensive Cancer CenterSan FranciscoUSA
  5. 5.Urology DepartmentUniversity of California San Diego Health SystemSan DiegoUSA
  6. 6.Urology Section, Department of SurgeryVeterans Affairs Greater Los Angeles Healthcare SystemLos AngelesUSA
  7. 7.Department of UrologyUCLA School of MedicineLos AngelesUSA
  8. 8.Section of UrologyVeterans Affairs Medical CenterAugustaUSA
  9. 9.Department of Surgery, Section of UrologyMedical College of GeorgiaAugustaUSA
  10. 10.Department of UrologyOregon Health and Science University HospitalPortlandUSA
  11. 11.Institute for Translational EpidemiologyIcahn School of Medicine at Mount SinaiNew YorkUSA
  12. 12.Department of Preventive MedicineUniversity of Tennessee Health Science CenterMemphisUSA
  13. 13.Division of Urology, Department of Surgery, Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesUSA

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