Advertisement

Cancer Causes & Control

, Volume 29, Issue 4–5, pp 435–443 | Cite as

Trends of two HPV-associated cancers in Massachusetts: cervical and oropharyngeal cancer

  • Erin E. Cook
  • Susan T. Gershman
  • Jane J. Kim
  • Rulla M. Tamimi
  • R. Monina Klevens
  • Michelle D. Holmes
Original paper
  • 236 Downloads

Abstract

Purpose

To understand trends in the incidence and mortality of two human papillomavirus (HPV)-associated cancers, cervical and oropharyngeal cancer, in Massachusetts.

Methods

From 2004 to 2014, the Massachusetts Cancer Registry recorded 3,996 incident cases of oropharyngeal cancer and 2,193 incident cases of cervical cancer. Mortality data were obtained from the Massachusetts Registry of Vital Records and Statistics from 2008 to 2014. Rates were age-standardized to the 2000 U.S. population and trends were assessed using joinpoint regression.

Results

While the incidence rate of cervical cancer (5.46 per 100,000) decreased by 2.41% annually (p = 0.004), the incidence rate of oropharyngeal cancer among males (7.85 per 100,000) increased by 2.82% annually (p = 0.0002). Mortality rates for both cancers decreased from 2008 to 2014 but were not statistically significant (cervical − 3.73% annually, p = 0.29; oropharyngeal − 1.94% annually, p = 0.44).

Conclusion

The rising incidence rate of oropharyngeal cancer in men and the decreasing, but relatively high, incidence rate of cervical cancer in women highlight the need for further screening and prevention by HPV vaccination in Massachusetts.

Keywords

Cancer Cervical cancer Oropharyngeal cancer Human papillomavirus (HPV) Massachusetts Population Surveillance 

Notes

Acknowledgments

We would like to thank Annie MacMillan and Richard Knowlton at the Massachusetts Cancer Registry and Susan Lett from the Division of Epidemiology and Immunization at the Massachusetts Department of Public Health for their help with this project. This journal article was supported by the Cooperative Agreement Number, NU58D006271, funded by the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention or the Department of Health and Human Services. We would also like to acknowledge funding from the grants R25 CA 98566-10, T32 CA 009001-40, and T32 ES 007069.

Funding

Funding was provided by National Institutes of Health (Grant Nos. R25 CA 98566-10, T32 CA 009001-40, and T32 ES 007069), Centers for Disease Control and Prevention (Cooperative Agreement Number 1 NU58DP006271-01-00).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10552_2018_1016_MOESM1_ESM.docx (24 kb)
Online Appendix 1 (DOCX 24 KB)
10552_2018_1016_MOESM2_ESM.docx (21 kb)
Online Appendix Table 2 (DOCX 21 KB)
10552_2018_1016_MOESM3_ESM.docx (16 kb)
Online Appendix Table 3 (DOCX 16 KB)
10552_2018_1016_MOESM4_ESM.docx (27 kb)
Online Appendix 2 The current cigarette smoking prevalence is shown for Massachusetts males, females, and the entire population of Massachusetts from 1990 to 2010 in comparison to the median prevalence in the United States from 1996 to 2010 in Figure 2a. The per capita ethanol consumption for Massachusetts and the United States from 1977 to 2010 is shown in Figure 2b. The annual percent change values for the trends are presented in the legend. For figures 2a and 2b, statistically significant trends (p < 0.05) in the APC are denoted with an *. (DOCX 27 KB)
10552_2018_1016_MOESM5_ESM.docx (26 kb)
Online Appendix 3 The prevalence of high school students having sex with 4 or more persons in Massachusetts and the United States is shown in Figure 3a. The prevalence of high school students having sex before age 13 in Massachusetts and the United States is shown in Figure 3b. The annual percent change values for the trends are presented in the legend. For figures 3a and 3b, statistically significant trends (p < 0.05) in the APC are denoted with an * (DOCX 26 KB)

References

  1. 1.
    Saraiya M, Unger ER, Thompson TD et al (2015) US Assessment of HPV Types in Cancers: Implications for Current and 9-Valent HPV Vaccines. JNCI J Natl Cancer Inst 107(6):djv086.  https://doi.org/10.1093/jnci/djv086 CrossRefPubMedGoogle Scholar
  2. 2.
    Viens LJ, Henley SJ, Watson M et al (2016) Human papillomavirus–associated cancers—United States, 2008–2012. MMWR Morb Mortal Wkly Rep 65:661–666.  https://doi.org/10.15585/mmwr.mm6526a1 CrossRefPubMedGoogle Scholar
  3. 3.
    Centers for Disease Control and Prevention HPV Cancer [online] (2016) https://www.cdc.gov/cancer/hpv/statistics/cases.htm. Accessed 22 Mar 2017
  4. 4.
    U.S. Department of Health and Human Services (DHHS) (2017) National Center for Health Statistics. The 2016 National Immunization Survey—Teen, Hyattsville: Centers for Disease Control and PreventionGoogle Scholar
  5. 5.
    United States Census Bureau. QuickFacts Massachusetts [online] (2016) https://www.census.gov/quickfacts/table/PST045216/25. Accessed 29 Mar 2017
  6. 6.
    North American Association of Central Cancer Registries (NAACCR). Certified Registries [online] (2016) https://www.naaccr.org/certified-registries/. Accessed 7 June 2017
  7. 7.
    Joinpoint Regression, Program, Version 4.4.0.0 - January 2017; Statistical Methodology and Applications Branch, Surveillance Research Program, National Cancer InstituteGoogle Scholar
  8. 8.
    SAS 9.3. Cary, NC, USA: SAS Institute IncGoogle Scholar
  9. 9.
    Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Population Health. BRFSS Prevalence & Trends Data [online] (2015) https://www.cdc.gov/brfss/brfssprevalence/. Accessed 10 May 2017
  10. 10.
    National Institute on Alcohol Abuse and Alcoholism. Surveillance Report #102 Apparent Per Capita Alcohol Consumption: National, State, and Regional Trends, 1977–2013. https://pubs.niaaa.nih.gov/publications/surveillance102/tab4-3_13.htm. Accessed 17 May 2017
  11. 11.
    Dunne EF, Unger ER, Sternberg M et al (2007) Prevalence of HPV infection among females in the United States. JAMA 297(8):813–819.  https://doi.org/10.1001/jama.297.8.813 CrossRefPubMedGoogle Scholar
  12. 12.
    Centers for Disease Control and Prevention (1993–2015) Youth Risk Behavior Survey Questionnaire. http://www.cdc.gov/yrbs. Accessed 17 May 2017
  13. 13.
    Chaturvedi AK, Engels EA, Pfeiffer RM et al (2011) Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 29(32):4294–4301.  https://doi.org/10.1200/JCO.2011.36.4596 CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    SEER Cancer Stat Facts: Cervix Uteri Cancer. National Cancer Institute. Bethesda, MD. http://seer.cancer.gov/statfacts/html/cervix.html
  15. 15.
    Howlander N, Noone AM, Krapcho M et al (2016) SEER Cancer Statistics Review, 1975–2014, National Cancer Institute. Bethesda, MD. https://seer.cancer.gov/csr/1975_2014/, based on November 2016 SEER data submission, posted to the SEER web site April 2017
  16. 16.
    Centers for Disease Control and Prevention. Gynecologic Cancers: Cervical Cancer Rates by Race Ethnicity [online] (2017) https://www.cdc.gov/cancer/cervical/statistics/race.htm. Accessed 15 Jan 2018
  17. 17.
    Pytynia KB, Dahlstrom KR, Sturgis EM (2014) Epidemiology of HPV-associated oropharyngeal cancer. Oral Oncol 50(5):380–386.  https://doi.org/10.1016/j.oraloncology.2013.12.019 CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Herbenick D, Reece M, Schick V et al (2010) Sexual behavior in the United States: results from a national probability sample of men and women ages 14–94. J Sex Med 7(Suppl 5):255–265CrossRefPubMedGoogle Scholar
  19. 19.
    Meites E, Kempe A, Markowitz LE (2016) Use of a 2-dose schedule for human papillomavirus vaccination—updated recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mort Wkly Rep 65:1405–1408.  https://doi.org/10.15585/mmwr.mm6549a5 CrossRefGoogle Scholar
  20. 20.
    Massachusetts Department of Public Health, Health Survey Program. Data Brief: Massachusetts Adolescent Health: Sexual Health, Experiences, and Behaviors (Spring 2016) http://www.mass.gov/eohhs/docs/dph/behavioral-risk/mass-adole-health-sexual-health.pdf. Accessed 17 May 2017
  21. 21.
    Addison D, Seidelmann SB, Jangua SA et al (2017) Human papillomavirus status and the risk of cerebrovascular events following radiation therapy for head and neck cancer. J Am Heart Assoc 6(9):e006453CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Lorch JH, Hanna GJ, Posner MR et al (2015) Human papillomavirus and induction chemotherapy versus concurrent chemoradiotherapy in locally advanced oropharyngeal cancer: the Dana Farber experience. Head Neck 38(S1):E1618–E1624Google Scholar
  23. 23.
    Nelson HH, Pawlita M, Michaud DS et al (2017) Immune response to HPV16 E6 and E7 proteins and patient outcomes in head and neck cancer. JAMA Oncol 3(2):178–185CrossRefGoogle Scholar
  24. 24.
    Nichols AC, Finkelstein DM, Faquin WC et al (2010) Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer. Clin Can Res 16(7):2138–2146CrossRefGoogle Scholar
  25. 25.
    Ringstrom E, Peters E, Hasegawa M et al (2002) Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res 8(10):3187–3192PubMedGoogle Scholar
  26. 26.
    Stang A, Hawk H, Knowlton RK et al (2014) Hysterectomy-corrected incidence rates of cervical and uterine cancers in Massachusetts, 1995 to 2010. Ann Epidemiol 24(11):849–854CrossRefPubMedGoogle Scholar
  27. 27.
    Massachusetts Department of Public Health. Massachusetts Comprehensive Cancer Prevention and Control Network (2017) http://www.mass.gov/eohhs/gov/departments/dph/programs/community-health/cancer-prev-and-control/program-structure.html. Accessed 19 July 2017
  28. 28.
    Wagner R, Villa A (2107) Oral human papillomavirus infections and the role of the dental professional. J Massachusetts Dent Soc 65(4):12–15Google Scholar
  29. 29.
    Massachusetts Cancer Registry, Massachusetts Department of Public Health (2018) http://www.mass.gov/dph/mcr. Accessed 12 Jan 2018

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of EpidemiologyHarvard T. H. Chan School of Public HealthBostonUSA
  2. 2.Massachusetts Cancer RegistryMassachusetts Department of Public HealthBostonUSA
  3. 3.Department of Health Policy and ManagementHarvard T. H. Chan School of Public HealthBostonUSA
  4. 4.Bureau of Infectious Disease and Laboratory SciencesMassachusetts Department of Public HealthBostonUSA
  5. 5.Channing Division of Network MedicineBrigham and Women’s HospitalBostonUSA

Personalised recommendations