Trends of two HPV-associated cancers in Massachusetts: cervical and oropharyngeal cancer
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To understand trends in the incidence and mortality of two human papillomavirus (HPV)-associated cancers, cervical and oropharyngeal cancer, in Massachusetts.
From 2004 to 2014, the Massachusetts Cancer Registry recorded 3,996 incident cases of oropharyngeal cancer and 2,193 incident cases of cervical cancer. Mortality data were obtained from the Massachusetts Registry of Vital Records and Statistics from 2008 to 2014. Rates were age-standardized to the 2000 U.S. population and trends were assessed using joinpoint regression.
While the incidence rate of cervical cancer (5.46 per 100,000) decreased by 2.41% annually (p = 0.004), the incidence rate of oropharyngeal cancer among males (7.85 per 100,000) increased by 2.82% annually (p = 0.0002). Mortality rates for both cancers decreased from 2008 to 2014 but were not statistically significant (cervical − 3.73% annually, p = 0.29; oropharyngeal − 1.94% annually, p = 0.44).
The rising incidence rate of oropharyngeal cancer in men and the decreasing, but relatively high, incidence rate of cervical cancer in women highlight the need for further screening and prevention by HPV vaccination in Massachusetts.
KeywordsCancer Cervical cancer Oropharyngeal cancer Human papillomavirus (HPV) Massachusetts Population Surveillance
We would like to thank Annie MacMillan and Richard Knowlton at the Massachusetts Cancer Registry and Susan Lett from the Division of Epidemiology and Immunization at the Massachusetts Department of Public Health for their help with this project. This journal article was supported by the Cooperative Agreement Number, NU58D006271, funded by the Centers for Disease Control and Prevention. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention or the Department of Health and Human Services. We would also like to acknowledge funding from the grants R25 CA 98566-10, T32 CA 009001-40, and T32 ES 007069.
Funding was provided by National Institutes of Health (Grant Nos. R25 CA 98566-10, T32 CA 009001-40, and T32 ES 007069), Centers for Disease Control and Prevention (Cooperative Agreement Number 1 NU58DP006271-01-00).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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