Abstract
Background
Breast cancer (BC) and genital organ cancers (GOC) are known to have a major impact on the quality of life of patients. The aim of this study was to analyze the risk of depression, anxiety, and adjustment disorders in women in Germany with a suspected but unconfirmed diagnosis of BC or GOC in their medical history.
Methods
This study included women who received a suspected diagnosis of BC or GOC and were followed between 2007 and 2015 (index date). These women were matched (1:1:1) by age to women with a confirmed diagnosis of BC or GOC and women without a cancer diagnosis. The main outcome measure of the study was the rate of depression, anxiety, and adjustment disorder diagnoses within 3 years of the index date.
Results
The present analysis included a total of 4,842 patients (mean age = 49.3 years). Within 3 years of the index date, 23.5% of women with a confirmed diagnosis of BC or GOC, 14.1% of those with a suspected diagnosis of BC or GOC, and 10.5% of those without a cancer diagnosis developed depression, anxiety, or an adjustment disorder (log-rank p value <0.001). Women with a suspected diagnosis of cancer were at a higher risk for these psychiatric conditions than those without a cancer diagnosis (BC and GOC: HR 1.32; BC: HR 1.21; GOC: HR 1.50).
Conclusion
A suspected diagnosis of BC or GOC in a woman’s medical history is associated with an increased risk of developing depression, anxiety, and adjustment disorders.
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KK, LJ, and MK have declared that they have no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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Kostev, K., Jacob, L. & Kalder, M. Risk of depression, anxiety, and adjustment disorders in women with a suspected but unconfirmed diagnosis of breast or genital organ cancer in Germany. Cancer Causes Control 28, 1021–1026 (2017). https://doi.org/10.1007/s10552-017-0948-1
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DOI: https://doi.org/10.1007/s10552-017-0948-1