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Coffee consumption and risk of renal cell carcinoma

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Abstract

Background

Studies have suggested an inverse association between coffee consumption and risk of renal cell carcinoma (RCC); however, data regarding decaffeinated coffee are limited.

Methods

We conducted a case–control study of 669 incident RCC cases and 1,001 frequency-matched controls. Participants completed identical risk factor questionnaires that solicited information about usual coffee consumption habits. The study participants were categorized as non-coffee, caffeinated coffee, decaffeinated coffee, or both caffeinated and decaffeinated coffee drinkers. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression, adjusting for multiple risk factors for RCC.

Results

Compared with no coffee consumption, we found an inverse association between caffeinated coffee consumption and RCC risk (OR 0.74; 95% CI 0.57–0.99), whereas we observed a trend toward increased risk of RCC for consumption of decaffeinated coffee (OR 1.47; 95% CI 0.98–2.19). Decaffeinated coffee consumption was associated also with increased risk of the clear cell RCC (ccRCC) subtype, particularly the aggressive form of ccRCC (OR 1.80; 95% CI 1.01–3.22).

Conclusions

Consumption of caffeinated coffee is associated with reduced risk of RCC, while decaffeinated coffee consumption is associated with an increase in risk of aggressive ccRCC. Further inquiry is warranted in large prospective studies and should include assessment of dose–response associations.

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Abbreviations

BMI:

Body mass index

ccRCC:

Clear cell renal cell carcinoma

CI:

Confidence interval

OR:

Odds ratio

RCC:

Renal cell carcinoma

SSIGN:

Stage, size, grade, and necrosis

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Acknowledgments

We are indebted to the participants of the Mayo Clinic Kidney Cancer Registry, participants of Mayo Clinic Biobank, and the participants from the Department of Family and Community Medicine at Mayo Clinic, Jacksonville, FL for their invaluable contributions to the study. The authors thank Victoria L. Jackson, MLIS, ELS, for her assistance with manuscript preparation and management.

Funding

The study was supported by a grant from the State of Florida James and Esther King Biomedical Research Program.

Author information

Authors and Affiliations

  1. Department of Health Sciences Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA

    Samuel O. Antwi, Nancy D. Diehl, Daniel J. Serie, Kaitlynn M. Custer, Michelle L. Arnold & Alexander S. Parker

  2. Department of Health Sciences Research, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA

    Jeanette E. Eckel-Passow

  3. Department of Laboratory Medicine and Pathology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA

    Kevin J. Wu & John C. Cheville

  4. Department of Urology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA

    David D. Thiel

  5. Department of Urology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA

    Bradley C. Leibovich

Authors
  1. Samuel O. Antwi
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  2. Jeanette E. Eckel-Passow
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  3. Nancy D. Diehl
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  4. Daniel J. Serie
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  5. Kaitlynn M. Custer
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  6. Michelle L. Arnold
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  7. Kevin J. Wu
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  8. John C. Cheville
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  9. David D. Thiel
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  10. Bradley C. Leibovich
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  11. Alexander S. Parker
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Contributions

SOA contributed in interpretation of data; drafting of the manuscript; final approval of the manuscript. JEE-P contributed in analysis and interpretation of data; critically revising the article; final approval of the manuscript. NDD contributed in analysis and interpretation of data; final approval of the manuscript. DJS contributed in analysis and interpretation of data; final approval of the manuscript. KMC contributed in acquisition of data; final approval of the manuscript. MLA contributed in acquisition of data; final approval of the manuscript. KJW contributed in acquisition of data; final approval of the manuscript. JCC contributed in acquisition of data; final approval of the manuscript. DDT contributed in acquisition of data; final approval of the manuscript. BCL contributed in acquisition of data; final approval of the manuscript. ASP contributed in conception and design; analysis and interpretation of data; drafting the article; final approval of the manuscript.

Corresponding author

Correspondence to Alexander S. Parker.

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Conflicts of interest

The authors have no conflicts of interest related to this work.

Ethical approval

The study was approved by the Mayo Clinic Institutional Review Board.

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Antwi, S.O., Eckel-Passow, J.E., Diehl, N.D. et al. Coffee consumption and risk of renal cell carcinoma. Cancer Causes Control 28, 857–866 (2017). https://doi.org/10.1007/s10552-017-0913-z

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  • DOI: https://doi.org/10.1007/s10552-017-0913-z

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