Skip to main content

Incidence of malignant mesothelioma in Germany 2009–2013

Abstract

Purpose

The malignant mesothelioma is a rare malignancy and mainly caused by occupational exposure to asbestos. German cancer registries are providing a national database to investigate temporal and regional patterns of mesothelioma incidence. These may be of interest for healthcare planning and for surveillance programs aiming at the formerly exposed workforce.

Methods

We analyzed population-based incidence data of malignant mesothelioma by site, type, sex, age, as well as district and state of patient’s residence. Age-standardized incidence rates (AIRs40+) were calculated according to the European standard population truncated to the age of 40 years and older. We present rates at national, state, and district level and trends of incidence of northern states of Germany.

Results

In total, 7,547 malignant mesotheliomas were reported to German cancer registries diagnosed between 2009 and 2013—90% located to the pleura. On average, 1,198 men and 312 women were affected each year. We estimated AIR40+ of 4.77 in 100,000 German men and 0.98 in 100,000 German women. Regional clusters were predominantly located to the seaports of West Germany. The highest regional AIR40+ was 20 per 100,000 men. Corresponding rates in northeast Germany were between 2 and 4 per 100,000 men.

Conclusion

Regional clusters of high incidence indicate districts with former shipyards and steel industry, but predominantly in the western part of Germany. The West-to-East difference corresponds to patterns of mortality. Twenty years after banning asbestos in Germany, Bremen and Hamburg are presenting the highest mesothelioma incidence but show steadily decreasing trends.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2

References

  1. 1.

    Husain AN, Colby T, Ordonez N et al (2013) Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med 137(5):647–667

    Article  PubMed  Google Scholar 

  2. 2.

    Scherpereel A, Astoul P, Baas P et al (2016) Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma. Eur Respir J 35(3):479–495

    Article  Google Scholar 

  3. 3.

    Delgermaa V, Takahashi K, Park E-K et al (2011) Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008. Bull World Health Organ 89(10):716

    Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Kotova S, Wong RM, Cameron RB (2015) New and emerging therapeutic options for malignant pleural mesothelioma: review of early clinical trials. Cancer Manag Res 7:51–63

    CAS  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Calabro L, Ceresoli GL, Di Pietro A et al (2015) CTLA4 blockade in mesothelioma: finally a competing strategy over cytotoxic/target therapy? Cancer Immunol Immunother 64(1):105–112

    CAS  Article  PubMed  Google Scholar 

  6. 6.

    Francisci S, Minicozzi P, Pierannunzio D et al (2015) Survival patterns in lung and pleural cancer in Europe 1999–2007: results from the EUROCARE-5 study. Eur J Cancer 51:2242–2253

    Article  Google Scholar 

  7. 7.

    Suzuki H, Asami K, Hirashima T et al (2014) Stratification of malignant pleural mesothelioma prognosis using recursive partitioning analysis. Lung 192(1):191–195

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Schonfeld SJ, McCormack V, Rutherford MJ et al (2014) Regional variations in German mesothelioma mortality rates: 2000–2010. Cancer Causes Control 25(5):615–624

    Article  PubMed  Google Scholar 

  9. 9.

    Soeberg MJ, Leigh J, Driscoll T et al (2016) Incidence and survival trends for malignant pleural and peritoneal mesothelioma, Australia, 1982–2009. Occup Environ Med 73:187–194

    Article  PubMed  Google Scholar 

  10. 10.

    Ji J, Sundquist J, Sundquist K (2016) Incidence and familial risk of pleural mesothelioma in Sweden: a national cohort study. Eur Respir J 48(3):873–879

    Article  PubMed  Google Scholar 

  11. 11.

    Pesch B, Taeger D, Johnen G et al (2010) Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos. Int J Hyg Environ Health 213(1):44–51

    Article  PubMed  Google Scholar 

  12. 12.

    Bianchi C, Bianchi T (2007) Malignant mesothelioma: global incidence and relationship with asbestos. Ind Health 45(3):379–387

    Article  PubMed  Google Scholar 

  13. 13.

    Burdorf A, Dahhan M, Swuste P (2003) Occupational characteristics of cases with asbestos-related diseases in the Netherlands. Ann Occup Hyg 47(6):485–492

    PubMed  Google Scholar 

  14. 14.

    Federal Institute for Occupational Safety and Health (BAuA) (2014) National Asbestos Profile for Germany, Dortmund Berlin Dresden

  15. 15.

    van Kampen V, Merget R, Butz M et al (2008) Trends in suspected and recognized occupational respiratory diseases in Germany between 1970 and 2005. Am J Ind Med 51(7):492–502

    Article  PubMed  Google Scholar 

  16. 16.

    Hagemeyer O, Otten H, Kraus T (2006) Asbestos consumption, asbestos exposure and asbestos-related occupational diseases in Germany. Int Arch Occup Environ Health 79(8):613–620

    CAS  Article  PubMed  Google Scholar 

  17. 17.

    Robert Koch Institute (ed) and the Association of Population-based Cancer Registries (2015) Cancer in Germany 2011/2012, Berlin

  18. 18.

    World Health Organization (2014) ICD-10: international statistical classification of diseases and related health problems, 10th edn. WHO Press, Geneva

    Google Scholar 

  19. 19.

    World Health Organization (2013) ICD-O: international classification of diseases for oncology, 3rd edn. WHO Press, Geneva

    Google Scholar 

  20. 20.

    Federal Statistical Office (2015) Population numbers. https://www-genesis.destatis.de/genesis/online

  21. 21.

    Waterhouse JAH, Muir CS, Correa P et al (1976) Cancer incidence in five continents. IARC, Lyon

    Google Scholar 

  22. 22.

    Doll R, Payne P, Waterhouse J (eds) (1966) Cancer incidence in five continents: a technical report. IARC Publications, Berlin

    Google Scholar 

  23. 23.

    Schönfeld I, Kraywinkel K (2014) Krebsepidemiologische Daten im Internet: Eine Übersicht über Informationsangebote im nationalen und europäischen Rahmen (Epidemiological cancer data online: an overview of information service in Germany and Europe). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(1):22–26

    Article  PubMed  Google Scholar 

  24. 24.

    Gatto MP, Tanna Di, Di Tanna GL (2013) Distribution and trends in mesothelioma mortality in Italy from 1974 to 2006. Int Arch Occup Environ Health 86(4):489–496

    CAS  Article  PubMed  Google Scholar 

  25. 25.

    Fazzo L, de Santis M, Minelli G et al (2012) Pleural mesothelioma mortality and asbestos exposure mapping in Italy. Am J Ind Med 55(1):11–24

    CAS  Article  PubMed  Google Scholar 

  26. 26.

    López-Abente G, García-Gómez M, Menéndez-Navarro A et al (2013) Pleural cancer mortality in Spain: time-trends and updating of predictions up to 2020. BMC Cancer 13:528

    Article  PubMed  PubMed Central  Google Scholar 

  27. 27.

    Nishikawa K, Takahashi K, Karjalainen A et al (2008) Recent mortality from pleural mesothelioma, historical patterns of asbestos use, and adoption of bans: a global assessment. Environ Health Perspect 116(12):1675–1680

    Article  PubMed  PubMed Central  Google Scholar 

  28. 28.

    Girardi P, Bressan V, Merler E (2014) Past trends and future prediction of mesothelioma incidence in an industrialized area of Italy, the Veneto Region. Cancer Epidemiol 38(5):496–503

    Article  PubMed  Google Scholar 

  29. 29.

    Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds) (2016) SEER Cancer Statistics Review (CSR) 1975–2013. http://seer.cancer.gov/csr/1975_2013

  30. 30.

    IARC (1973) Some inorganic and organometallic compounds. IARC Monographs, Lyon

    Google Scholar 

  31. 31.

    Netherlands Comprehensive Cancer Organisation (2016) http://www.cijfersoverkanker.nl

  32. 32.

    Office of National Statistics (2016) Cancer Registration Statistics, England. http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/datasets/cancerregistrationstatisticscancerregistrationstatisticsengland

  33. 33.

    Virta RL (2006) Worldwide asbestos supply and consumption trends from 1900 through 2003: U.S. Geological Survey Circular 1298, 03–083, Reston, Virginia, USA

  34. 34.

    Federal Statistical Office (1980) Statistical yearbook 1980 for the Federal Republik of Germany, Wiesbaden

  35. 35.

    Müglich W, Ziem H (1995) Asbest an den Arbeitsplätzen in der DDR. Sankt Augustin

  36. 36.

    Lippmann M (2014) Toxicological and epidemiological studies on effects of airborne fibers: coherence and public [corrected] health implications. Crit Rev Toxicol 44(8):643–695

    CAS  Article  PubMed  Google Scholar 

  37. 37.

    Langhoff MD, Kragh-Thomsen MB, Stanislaus S et al (2014) Almost half of women with malignant mesothelioma were exposed to asbestos at home through their husbands or sons. Dan Med J 61(9):A4902

    PubMed  Google Scholar 

  38. 38.

    Comin CE, Saieva C, Messerini L (2007) h-caldesmon, calretinin, estrogen receptor, and Ber-EP4: a useful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary. Am J Surg Pathol 31(8):1139–1148

    Article  PubMed  Google Scholar 

  39. 39.

    Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJL, Lozano R, Inoue M (2001) Age standardization of rates: a new WHO standard. GPE Discussion Paper 31

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Martin Lehnert.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Lehnert, M., Kraywinkel, K., Heinze, E. et al. Incidence of malignant mesothelioma in Germany 2009–2013. Cancer Causes Control 28, 97–105 (2017). https://doi.org/10.1007/s10552-016-0838-y

Download citation

Keywords

  • Asbestos
  • Mesothelioma
  • Incidence
  • Germany