Fluoride exposure in public drinking water and childhood and adolescent osteosarcoma in Texas
- 631 Downloads
The purpose of this study was to examine the association between fluoride levels in public drinking water and childhood and adolescent osteosarcoma in Texas; to date, studies examining this relationship have been equivocal. Using areas with high and low naturally occurring fluoride, as well as areas with optimal fluoridation, we examined a wide range of fluoride levels in public drinking water.
This was a population-based case–control study, with both cases and controls obtained from the Texas Cancer Registry. Eligible cases were Texas children and adolescents <20 years old diagnosed with osteosarcoma between 1996 and 2006. Controls were sampled from children and adolescents diagnosed with either central nervous system (CNS) tumors or leukemia during the same time frame. Using geocoded patient addresses at the time of diagnosis, we estimated patients’ drinking water fluoride exposure levels based on the fluoride levels of their residence’s public water system (PWS). Unconditional logistic regression models were used to assess the association between osteosarcoma and public drinking water fluoride level, adjusting for several demographic risk factors.
Three hundred and eight osteosarcoma cases, 598 leukemia controls, and 604 CNS tumor controls met selection criteria and were assigned a corresponding PWS fluoride level. PWS fluoride level was not associated with osteosarcoma, either in a univariable analysis or after adjusting for age, sex, race, and poverty index. Stratified analyses by sex were conducted; no association between PWS fluoride level and osteosarcoma was observed among either males or females.
No relationship was found between fluoride levels in public drinking water and childhood/adolescent osteosarcoma in Texas.
KeywordsChildhood osteosarcoma Fluoridation Cancer epidemiology Public drinking water
- 3.National Research Council of the National Academies (NRC) (2006) Fluoride in drinking water—a scientific review of EPA’s standards. National Academies Press, WashingtonGoogle Scholar
- 5.Centers for Disease Control and Prevention (CDC) (1999) Ten great public health achievements—United States, 1900–1999. MMWR Morb Mortal Wkly Rep 48:241–243Google Scholar
- 11.Cohn PD (1992) A brief report on the association of drinking water fluoridation and the incidence of osteosarcoma among young males. New Jersey Department of Environment Protection and New Jersey Department of HealthGoogle Scholar
- 12.Hoover RN, Devesa SS, Cantor KP, Lubin JH, Fraumeni JF (1991) Time trends for bone and joint cancers and osteosarcomas in the surveillance, epidemiology and end results (SEER) program. US Public Health Service, WashingtonGoogle Scholar