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Air pollution from traffic and risk for brain tumors: a nationwide study in Denmark

Cancer Causes & Control volume 27, pages 473–480 (2016)Cite this article

Abstract

Purpose

Air pollution is an established lung carcinogen, and there is increasing evidence that air pollution also negatively affects the brain. We have previously reported an association between air pollution and risk of brain tumors in a cohort study based on only 95 cases. We set out to replicate that finding in a large nationwide case–control study.

Methods

We identified all 4,183 adult brain tumor cases in Denmark in the years 2000–2009 and 8,018 risk set sampled population controls matched on gender and year of birth. We extracted residential address histories and estimated mean residential nitrogen oxides (NO x ) concentrations since 1971 with a validated dispersion model. Categorical and linear odds ratios (OR) and confidence intervals (CI) were calculated with conditional logistic regression models.

Results

The highest risk estimates for any brain cancer were observed among subjects with the highest average exposure levels (80–99 µg/m3: OR 1.27, 95 % CI 0.82–1.96; ≥100 µg/m3: 1.40, 95 % CI 0.87–2.26 as compared to <20 µg/m3 NO x ), but there was no increased OR at NO x levels below 80 µg/m3 and when modeled linearly there was no significant association with risk of brain cancer (OR 1.11, 95 % CI 0.84–1.46 per 100 µg/m3 NO x ). In sub-analysis the OR associated with exposures ≥100 µg/m3 was 2.30 (95 % CI 1.15–4.59) for non-glioma and 0.89 (95 % CI 0.44–1.77) for glioma.

Conclusions

This study did not support the relatively strong linear association between air pollution and risk of brain tumors which was found in our previous study. The suggestion of an increased brain tumor risk at high exposures merits further attention as does the differing results according to tumor morphology.

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References

  1. Bondy ML, Scheurer ME, Malmer B et al (2008) Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer 113:1953–1968

    Article  PubMed  PubMed Central  Google Scholar 

  2. Loomis D, Grosse Y, Lauby-Secretan B et al (2013) The carcinogenicity of outdoor air pollution. Lancet Oncol 14:1262–1263

    CAS  Article  PubMed  Google Scholar 

  3. Benbrahim-Tallaa L, Baan RA, Grosse Y et al (2012) Carcinogenicity of diesel-engine and gasoline-engine exhausts and some nitroarenes. Lancet Oncol 13:663–664

    Article  PubMed  Google Scholar 

  4. Ranft U, Schikowski T, Sugiri D, Krutmann J, Kramer U (2009) Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly. Environ Res 109:1004–1011

    CAS  Article  PubMed  Google Scholar 

  5. Gatto NM, Henderson VW, Hodis HN et al (2014) Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles. Neurotoxicology 40:1–7

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. Corea F, Silvestrelli G, Baccarelli A et al (2012) Airborne pollutants and lacunar stroke: a case cross-over analysis on stroke unit admissions. Neurol Int 4:e11

    Article  PubMed  PubMed Central  Google Scholar 

  7. Power MC, Weisskopf MG, Alexeeff SE, Coull BA, Spiro A III, Schwartz J (2011) Traffic-related air pollution and cognitive function in a cohort of older men. Environ Health Perspect 119:682–687

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. Andersen ZJ, Olsen TS, Andersen KK, Loft S, Ketzel M, Raaschou-Nielsen O (2010) Association between short-term exposure to ultrafine particles and hospital admissions for stroke in Copenhagen, Denmark. Eur Heart J 31:2034–2040

    CAS  Article  PubMed  Google Scholar 

  9. Andersen ZJ, Kristiansen LC, Andersen KK et al (2012) Stroke and long-term exposure to outdoor air pollution from nitrogen dioxide: a cohort study. Stroke 43:320–325

    CAS  Article  PubMed  Google Scholar 

  10. Block ML, Calderon-Garciduenas L (2009) Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci 32:506–516

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  11. Genc S, Zadeoglulari Z, Fuss SH, Genc K (2012) The adverse effects of air pollution on the nervous system. J Toxicol 2012:782462

    PubMed  PubMed Central  Google Scholar 

  12. Boeglin ML, Wessels D, Henshel D (2006) An investigation of the relationship between air emissions of volatile organic compounds and the incidence of cancer in Indiana counties. Environ Res 100:242–254

    CAS  Article  PubMed  Google Scholar 

  13. McKean-Cowdin R, Calle EE, Peters JM et al (2009) Ambient air pollution and brain cancer mortality. Cancer Causes Control 20:1645–1651

    Article  PubMed  Google Scholar 

  14. Liu CC, Chen CC, Wu TN, Yang CY (2008) Association of brain cancer with residential exposure to petrochemical air pollution in Taiwan. J Toxicol Environ Health A 71:310–314

    CAS  Article  PubMed  Google Scholar 

  15. Raaschou-Nielsen O, Andersen ZJ, Hvidberg M et al (2011) Air pollution from traffic and cancer incidence: a Danish cohort study. Environ Health 10:67

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  16. Thygesen LC, Daasnes C, Thaulow I, Bronnum-Hansen H (2011) Introduction to Danish (nationwide) registers on health and social issues: structure, access, legislation, and archiving. Scand J Public Health 39:12–16

    Article  PubMed  Google Scholar 

  17. Pedersen CB (2011) The Danish civil registration system. Scand J Public Health 39:22–25

    Article  PubMed  Google Scholar 

  18. Gjerstorff ML (2011) The Danish cancer registry. Scand J Public Health 39:42–45

    Article  PubMed  Google Scholar 

  19. Storm HH, Michelsen EV, Clemmensen IH, Pihl J (1997) The Danish Cancer Registry—history, content, quality and use. Dan Med Bull 44:535–539

    CAS  PubMed  Google Scholar 

  20. Raaschou-Nielsen O, Sorensen M, Ketzel M et al (2013) Long-term exposure to traffic-related air pollution and diabetes-associated mortality: a cohort study. Diabetologia 56:36–46

    CAS  PubMed  Google Scholar 

  21. Berkowicz R, Ketzel M, Jensen SS, Hvidberg M, Raaschou-Nielsen O (2008) Evaluation and application of OSPM for traffic pollution assessment for a large number of street locations. Environ Model Softw 23:296–303

    Article  Google Scholar 

  22. Raaschou-Nielsen O, Hertel O, Vignati E et al (2000) An air pollution model for use in epidemiological studies: evaluation with measured levels of nitrogen dioxide and benzene. J Expo Anal Environ Epidemiol 10:4–14

    CAS  Article  PubMed  Google Scholar 

  23. Ketzel M, Berkowicz R, Hvidberg M, Jensen SS, Raaschou-Nielsen O (2011) Evaluation of AirGIS: a GIS-based air pollution and human exposure modelling system. Int J Environ Pollut 47:226–238

    CAS  Article  Google Scholar 

  24. Ketzel M, Wahlin P, Berkowicz R, Palmgren F (2003) Particle and trace gas emission factors under urban driving conditions in Copenhagen based on street and roof level observations. Atmos Environ 37:2735–2749

    CAS  Article  Google Scholar 

  25. Hertel O, Jensen S, Andersen H et al (2001) Human exposure to traffic pollution. Experience from Danish studies. Pure Appl Chem 73:137–145

    CAS  Google Scholar 

  26. Sorensen M, Hoffmann B, Hvidberg M et al (2012) Long-term exposure to traffic-related air pollution associated with blood pressure and self-reported hypertension in a Danish cohort. Environ Health Perspect 120:418–424

    Article  PubMed  PubMed Central  Google Scholar 

  27. Andersen ZJ, de Nazelle A, Mendez MA et al (2015) A study of the combined effects of physical activity and air pollution on mortality in elderly urban residents: the Danish diet, cancer, and health cohort. Environ Health Perspect 123:557–563

    PubMed  PubMed Central  Google Scholar 

  28. Andersen ZJ, Bonnelykke K, Hvidberg M et al (2012) Long-term exposure to air pollution and asthma hospitalisations in older adults: a cohort study. Thorax 67:6–11

    Article  PubMed  Google Scholar 

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Acknowledgments

We wish to express particular thanks to Nick Martinussen for his tireless efforts with the data management.

Author information

Affiliations

  1. Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark

    Aslak Harbo Poulsen, Mette Sørensen & Ole Raaschou-Nielsen

  2. Department of Public Health, Center for Epidemiology and Screening, University of Copenhagen, Copenhagen, Denmark

    Zorana J. Andersen

  3. Department of Environmental Science, Aarhus University, Roskilde, Denmark

    Matthias Ketzel & Ole Raaschou-Nielsen

Authors
  1. Aslak Harbo Poulsen
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  2. Mette Sørensen
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  3. Zorana J. Andersen
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  4. Matthias Ketzel
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  5. Ole Raaschou-Nielsen
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Corresponding author

Correspondence to Aslak Harbo Poulsen.

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Poulsen, A.H., Sørensen, M., Andersen, Z.J. et al. Air pollution from traffic and risk for brain tumors: a nationwide study in Denmark. Cancer Causes Control 27, 473–480 (2016). https://doi.org/10.1007/s10552-016-0721-x

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  • DOI: https://doi.org/10.1007/s10552-016-0721-x

Keywords

  • Epidemiology
  • Brain cancer
  • Nitrous oxides
  • Air pollution