Concerns regarding a possible link between bisphenol A (BPA) and breast cancer have been mounting, but studies in human populations are lacking. We evaluated the association between the major urinary BPA metabolite [BPA-glucuronide (BPA-G)] and postmenopausal breast cancer risk in a large population-based case–control study conducted in two cities in Poland (2000–2003); we further explored the association of BPA-G levels with known postmenopausal breast cancer risk factors in our control population.
We analyzed creatinine-adjusted urinary BPA-G levels among 575 postmenopausal cases matched on age and study site to 575 controls without breast cancer using a recently developed assay. Odds ratios and 95 % confidence intervals were used to estimate the association between urinary BPA-G level and breast cancer using conditional logistic regression. Among controls, geometric mean BPA-G levels were compared across categories of breast cancer risk factors using linear regression models.
There was no indication that increased BPA-G was associated with postmenopausal breast cancer (p-trend = 0.59). Among controls, mean BPA-G was higher among women reporting extended use of menopausal hormones, a prior screening mammogram, and residence in Warsaw. Other comparisons across strata of postmenopausal breast cancer risk factors were not related to differences in BPA-G.
Urinary BPA-G, measured at the time of diagnosis, is not linked to postmenopausal breast cancer.
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Talsness CE, Andrade AJ, Kuriyama SN, Taylor JA, vom Saal FS (2009) Components of plastic: experimental studies in animals and relevance for human health. Philos Trans R Soc Lond B Biol Sci 364(1526):2079–2096. doi:10.1098/rstb.2008.0281
Stahlhut RW, Welshons WV, Swan SH (2009) Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both. Environ Health Perspect 117(5):784–789. doi:10.1289/ehp.0800376
Durando M, Kass L, Perdomo V, Bosquiazzo VL, Luque EH, Munoz-de-Toro M (2011) Prenatal exposure to bisphenol A promotes angiogenesis and alters steroid-mediated responses in the mammary glands of cycling rats. J Steroid Biochem Mol Biol 127(1–2):35–43. doi:10.1016/j.jsbmb.2011.04.001
Durando M, Kass L, Piva J et al (2007) Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats. Environ Health Perspect 115(1):80–86
Tharp AP, Maffini MV, Hunt PA, Vandevoort CA, Sonnenschein C, Soto AM (2012) Bisphenol A alters the development of the rhesus monkey mammary gland. Proc Natl Acad Sci USA 109(21):8190–8195. doi:10.1073/pnas.1120488109
Dairkee SH, Seok J, Champion S et al (2008) Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients. Cancer Res 68(7):2076–2080. doi:10.1158/0008-5472
Recchia AG, Vivacqua A, Gabriele S et al (2004) Xenoestrogens and the induction of proliferative effects in breast cancer cells via direct activation of oestrogen receptor alpha. Food Addit Contam 21(2):134–144. doi:10.1080/02652030310001641177
Vivacqua A, Recchia AG, Fasanella G et al (2003) The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells. Endocrine 22(3):275–284. doi:10.1385/ENDO:22:3:275
Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, Needham LL (2005) Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environ Health Perspect 113(4):391–395
Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL (2008) Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003–2004. Environ Health Perspect 116(1):39–44. doi:10.1289/ehp.10753
Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV (2007) Human exposure to bisphenol A (BPA). Reprod Toxicol 24(2):139–177. doi:10.1016/j.reprotox.2007.07.010
Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS (2010) Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. PLoS One 5(1):e8673. doi:10.1371/journal.pone.0008673
Carwile JL, Michels KB (2011) Urinary bisphenol A and obesity: NHANES 2003–2006. Environ Res 111(6):825–830. doi:10.1016/j.envres.2011.05.014
Yang M, Ryu JH, Jeon R, Kang D, Yoo KY (2009) Effects of bisphenol A on breast cancer and its risk factors. Arch Toxicol 83(3):281–285. doi:10.1007/s00204-008-0364-0
Volkel W, Colnot T, Csanady GA, Filser JG, Dekant W (2002) Metabolism and kinetics of bisphenol a in humans at low doses following oral administration. Chem Res Toxicol 15(10):1281–1287
Garcia-Closas M, Brinton LA, Lissowska J et al (2006) Established breast cancer risk factors by clinically important tumour characteristics. Br J Cancer 95(1):123–129. doi:10.1038/sj.bjc.6603207
Fox SD, Falk RT, Veenstra TD, Issaq HJ (2011) Quantitation of free and total bisphenol A in human urine using liquid chromatography-tandem mass spectrometry. J Sep Sci 34(11):1268–1274. doi:10.1002/jssc.201100087
Nachman RM, Fox SD, Golden WC et al (2013) Urinary free bisphenol A and bisphenol A-glucuronide concentrations in newborns. J Pediatr 162(4):870–872. doi:10.1016/j.jpeds.2012.11.083
Calafat AM, Koch HM, Swan SH et al (2013) Misuse of blood serum to assess exposure to bisphenol A and phthalates. Breast Cancer Res 15(5):403. doi:10.1186/bcr3494
Harthe C, Rinaldi S, Achaintre D et al (2012) Bisphenol A-glucuronide measurement in urine samples. Talanta 100:410–413. doi:10.1016/j.talanta.2012.07.099
Lang IA, Galloway TS, Scarlett A et al (2008) Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 300(11):1303–1310. doi:10.1001/jama.300.11.1303
Melzer D, Osborne NJ, Henley WE et al (2012) Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation 125(12):1482–1490. doi:10.1161/CIRCULATIONAHA.111.069153
Wang T, Li M, Chen B et al (2012) Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. J Clin Endocrinol Metab 97(2):E223–E227. doi:10.1210/jc.2011-1989
Sprague BL, Trentham-Dietz A, Hedman CJ et al (2013) Circulating serum xenoestrogens and mammographic breast density. Breast Cancer Res 15(3):R45. doi:10.1186/bcr3432
Townsend MK, Franke AA, Li X et al (2013) Within-person reproducibility of urinary bisphenol A and phthalate metabolites over a 1–3 year period among women in the Nurses’ Health Studies: a prospective cohort study. Environ Health 12(1):80. doi:10.1186/1476-069X-12-80
Braun JM, Kalkbrenner AE, Calafat AM et al (2011) Variability and predictors of urinary bisphenol A concentrations during pregnancy. Environ Health Perspect 119(10):131–137. doi:10.1289/ehp.1002366
Ye X, Wong LY, Bishop AM, Calafat AM (2011) Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-h collections. Environ Health Perspect 119(7):983–988. doi:10.1289/ehp.1002701
This research was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics and by contracts from the Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services.
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The authors declare that they have no actual or potential competing financial interests.
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Trabert, B., Falk, R.T., Figueroa, J.D. et al. Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland. Cancer Causes Control 25, 1587–1593 (2014). https://doi.org/10.1007/s10552-014-0461-8
- Breast cancer
- Bisphenol A-glucuronide