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Associations between circulating 1,25(OH)2D concentration and odds of metachronous colorectal adenoma

Cancer Causes & Control volume 25, pages 809–817 (2014)Cite this article

Abstract

Cellular-level studies demonstrate that the availability of the secosteroid hormone 1α,25-dihydroxyvitamin D [1,25(OH)2D] to colon cells promotes anti-carcinogenic activities. Although epidemiological data are relatively sparse, suggestive inverse trends have been reported between circulating 1,25(OH)2D concentration and colorectal neoplasia. We therefore sought to evaluate the relationship between circulating 1,25(OH)2D concentrations and odds for metachronous colorectal adenomas among 1,151 participants from a randomized trial of ursodeoxycholic acid for colorectal adenoma prevention. No relationship between 1,25(OH)2D and overall odds for metachronous lesions was observed, with ORs (95 % CIs) of 0.80 (0.60–1.07) and 0.81 (0.60–1.10) for participants in the second and third tertiles, respectively, compared with those in the lowest (p-trend = 0.17). However, a statistically significant inverse association was observed between circulating 1,25(OH)2D concentration and odds of proximal metachronous adenoma, with an OR (95 % CI) of 0.71 (0.52–0.98) for individuals in the highest tertile of 1,25(OH)2D compared with those in the lowest (p-trend = 0.04). While there was no relationship overall between 1,25(OH)2D and metachronous distal lesions, there was a significantly reduced odds for women, but not men, in the highest 1,25(OH)2D tertile compared with the lowest (OR 0.53; 95 % CI 0.27–1.03; p-trend = 0.05; p-interaction = 0.08). The observed differences in associations with proximal and distal adenomas could indicate that delivery and activity of vitamin D metabolites in different anatomic sites in the colorectum varies, particularly by gender. These results identify novel associations between 1,25(OH)2D and metachronous proximal and distal colorectal adenoma, and suggest that future studies are needed to ascertain potential mechanistic differences in 1,25(OH)2D action in the colorectum.

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Acknowledgments

This work was supported by the R25T training fellowship (R25CA078447) awarded to EH as well as a grant from the National Cancer Institute (R01CA140285) to EJ and PJ. EH was responsible for conducting the epidemiologic analysis and writing the manuscript. EJ, CS, PL, and PJ were responsible for assisting with manuscript preparation and editing as well as evaluating the analysis. No authors have any financial conflicts of interest to disclose.

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The authors have no conflicts to disclose.

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Authors and Affiliations

  1. University of Arizona Cancer Center, 1515 N. Campbell Ave, Tucson, AZ, 85724-5024, USA

    Elizabeth A. Hibler, Peter Lance & Elizabeth T. Jacobs

  2. Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA

    Elizabeth A. Hibler, Christine L. Sardo Molmenti & Elizabeth T. Jacobs

  3. Mailman School of Public Health, Columbia University, New York, NY, USA

    Christine L. Sardo Molmenti

  4. School of Mathematical and Natural Sciences, Arizona State University, Phoenix, AZ, USA

    Peter W. Jurutka

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  1. Elizabeth A. Hibler
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  2. Christine L. Sardo Molmenti
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  3. Peter Lance
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  4. Peter W. Jurutka
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  5. Elizabeth T. Jacobs
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Correspondence to Elizabeth A. Hibler.

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Hibler, E.A., Sardo Molmenti, C.L., Lance, P. et al. Associations between circulating 1,25(OH)2D concentration and odds of metachronous colorectal adenoma. Cancer Causes Control 25, 809–817 (2014). https://doi.org/10.1007/s10552-014-0382-6

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  • DOI: https://doi.org/10.1007/s10552-014-0382-6

Keywords

  • Vitamin D
  • Colon cancer
  • 1,25(OH)2D
  • Colorectal adenoma