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Exposure to household painting and floor treatments, and parental occupational paint exposure and risk of childhood brain tumors: results from an Australian case–control study

An Erratum to this article was published on 20 June 2014

Abstract

Purpose

Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. This study investigated whether household exposure to paints and floor treatments and parental occupational painting were associated with CBT risk in a population-based case–control study conducted between 2005 and 2010.

Methods

Cases were identified through all ten Australian pediatric oncology centers, and controls via nationwide random-digit dialing, frequency matched to cases on age, sex, and state of residence. Data were obtained from parents in mailed questionnaires and telephone interviews. Information on domestic painting and floor treatments, and parental occupational exposure to paint, in key periods relating to the index pregnancy and childhood was obtained for 306 cases and 950 controls. Data were analyzed using unconditional logistic regression, adjusting for frequency matching variables and potential confounders.

Results

Overall, we found little evidence that parental, fetal, or childhood exposure to home painting or floor treatments was associated with risk of CBT. There was, though, some evidence of a positive association between childhood exposure to indoor painting and risk of high-grade glioma [odds ratio (OR) 3.31, 95 % confidence interval (CI) 1.29, 8.52] based on very small numbers. The OR for the association between CBT and paternal occupational exposure to paint any time before the pregnancy was 1.32 (95 % CI 0.90, 1.92), which is consistent with the results of other studies.

Conclusions

Overall, we found little evidence of associations between household exposure to paint and the risk of CBT in any of the time periods investigated.

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Abbreviations

CBT:

Childhood brain tumors

ALL:

Acute lymphoblastic leukemia

CATI:

Computer-assisted telephone interview

OR:

Odds ratio

CI:

Confidence interval

References

  1. Baldwin RT, Preston-Martin S (2004) Epidemiology of brain tumors in childhood—a review. Toxicol Appl Pharmacol 199:118–131

    CAS  PubMed  Article  Google Scholar 

  2. Savage SA, Schuz J (2011) Environmental chemicals and childhood cancer. Encyclopedia of Environmental Health. Elsevier [http://www.sciencedirect.com/science/referenceworks/9780444522726]

  3. Infante-Rivard C, Weichenthal S (2007) Pesticides and childhood cancer: an update of Zahm and Ward’s 1998 review. J Toxicol Environ Health 10:81–99

    CAS  Article  Google Scholar 

  4. Savitz DA, Chen JH (1990) Parental occupation and childhood cancer: review of epidemiologic studies. Environ Health Perspect 88:325–337

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  5. Cordier S, Lefeuvre B, Filippini G, Peris-Bonet R, Farinotti M, Lovicu G, Mandereau L (1997) Parental occupation, occupational exposure to solvents and polycyclic aromatic hydrocarbons and risk of childhood brain tumors (Italy, France, Spain). Cancer Causes Control 8:688–697

    CAS  PubMed  Article  Google Scholar 

  6. Feychting M, Plato N, Nise G, Ahlbom A (2001) Paternal occupational exposures and childhood cancer. Environ Health Perspect 109:193–196

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  7. McKinney PA, Fear NT, Stockton D (2003) Parental occupation at periconception: findings from the United Kingdom Childhood Cancer Study. Occup Environ Med 60:901–909

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  8. Rosso AL, Hovinga ME, Rorke-Adams LB, Spector LG, Bunin GR (2008) A case-control study of childhood brain tumors and fathers’ hobbies: a Children’s Oncology Group study. Cancer Causes Control 19:1201–1207

    PubMed Central  PubMed  Article  Google Scholar 

  9. Bunin GR, Buckley JD, Boesel CP, Rorke LB, Meadows AT (1994) Risk factors for astrocytic glioma and primitive neuroectodermal tumor of the brain in young children: a report from the Children’s Cancer Group. Cancer Epidemiol Biomarkers Prev 3:197–204

    CAS  PubMed  Google Scholar 

  10. International Agency for Research on Cancer (2012) Chemical agents and related occupations. IARC monographs on the evaluation of carcinogenic risks to humans, vol 100F. World Health Organization, Lyon

    Google Scholar 

  11. Garland EL, Howard MO (2012) Volatile substance misuse : clinical considerations, neuropsychopharmacology and potential role of pharmacotherapy in management. CNS Drugs 26:927–935

    CAS  PubMed  Article  Google Scholar 

  12. Gerasimov MR (2004) Brain uptake and biodistribution of [11C]toluene in nonhuman primates and mice. Methods Enzymol 385:334–349

    CAS  PubMed  Article  Google Scholar 

  13. Nakai N, Murata M, Nagahama M, Hirase T, Tanaka M, Fujikawa T, Nakao N, Nakashima K, Kawanishi S (2003) Oxidative DNA damage induced by toluene is involved in its male reproductive toxicity. Free Radic Res 37:69–76

    CAS  PubMed  Article  Google Scholar 

  14. Davis DL, Friedler G, Mattison D, Morris R (1992) Male-mediated teratogenesis and other reproductive effects: biologic and epidemiologic findings and a plea for clinical research. Reprod Toxicol 6:289–292

    CAS  PubMed  Article  Google Scholar 

  15. Anderson LM, Diwan BA, Fear NT, Roman E (2000) Critical windows of exposure for children’s health: cancer in human epidemiological studies and neoplasms in experimental animal models. Environ Health Perspect 108(Suppl 3):573–594

    PubMed Central  PubMed  Article  Google Scholar 

  16. Milne E, Greenop KR, Bower C, Miller M, van Bockxmeer FM, Scott RJ, de Klerk NH, Ashton LJ, Gottardo NG, Armstrong BK (2012) Maternal use of folic acid and other supplements and risk of childhood brain tumors. Cancer Epidemiol Biomarkers Prev 21:1933–1941

    CAS  PubMed  Article  Google Scholar 

  17. Bailey H, Milne E, de Klerk N, Fritschi L, Bower C, Attia J, Armstrong B (2010) Representativeness of child controls recruited by random digit dialling. Paediatr Perinat Epidemiol 24:293–302

    PubMed  Article  Google Scholar 

  18. Rothman KJ, Greenland S, Lash TL (2008) Design strategies to improve study accuracy. In: Rothman KJ, Greenland S, Lash TL (eds) Modern epidemiology, 3rd edn. Wolters Kluwer Health, Lippincott, Williams & Wilkins, Philadelphia, PA, pp 168–182

    Google Scholar 

  19. Bailey HD, Milne E, de Klerk NH, Fritschi L, Attia J, Cole C, Armstrong BK (2011) Exposure to house painting and the use of floor treatments and the risk of childhood acute lymphoblastic leukemia. Int J Cancer 128:2405–2414

    CAS  PubMed  Article  Google Scholar 

  20. Kuijten RR, Bunin GR, Nass CC, Meadows AT (1992) Parental occupation and childhood astrocytoma: results of a case-control study. Cancer Res 52:782–786

    CAS  PubMed  Google Scholar 

  21. Van De Mark MR, Sandefur KD, Durham KA (2005) Paint. In: Kirk-Othmer Encyclopedia of Chemical Technology, 5th edn. Wiley, New York, pp 54–75

  22. Australian Bureau of Statistics (2008) Western Australia Statistical Indicators, Sept 2008.Cat. No: 1367.5. ABS, Commonwealth of Australia. [http://www.abs.gov.au/AUSSTATS/abs@.nsf/DetailsPage/1367.5Sep%202008]. Accessed Sept 2012

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Acknowledgments

The authors acknowledge the contribution made by our clinical co-investigators who recruited and cared for study patients at each participating hospital: Nicholas Gottardo (Princess Margaret Hospital, TICHR); John Heath and Elizabeth Smibert (Royal Children’s Hospital, Melbourne); Peter Downie (Monash Medical Centre, Melbourne); Tim Hassall and Ross Pinkerton (Royal Children’s Hospital Brisbane); Maria Kirby (Women’s and Children’s Hospital, Adelaide); Stewart Kellie and Luciano dalla Pozza (Westmead Hospital); Frank Alvaro (John Hunter Hospital, Newcastle); Richard Cohn (Sydney Children’s Hospital); and John Daubenton (Royal Hobart Hospital). The authors also acknowledge the Clinical Research Associates at each hospital, and the study coordinators: Jackie Mansour, Somer Dawson, and Tamika Heiden.

Consortium statement

The Aus-CBT consortium conducted the study and the Telethon Institute for Child Health Research (TICHR), University of Western Australia, was the coordinating center. Elizabeth Milne, Nicholas de Klerk, Carol Bower, Peter Dallas (TICHR), Bruce Armstrong (Sydney School of Public Health, University of Sydney), Frank van Bockxmeer (Royal Perth Hospital, University of WA), Rodney Scott and John Attia (University of Newcastle), Lin Fritschi (WA Institute for Medical Research), Lesley Ashton, Michelle Haber and Murray Norris (Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW), Margaret Miller (Edith Cowan University), and Judith Thompson (WA Cancer Registry) were the research investigators.

Funding

The National Health and Medical Research Council (NHMRC) funded Aus-ALL (Grant Number: 254539) and Aus-CBT (Grant Number: 404089). Elizabeth Milne and Lin Fritschi were supported by NHMRC Fellowships, and Helen Bailey was supported by NHMRC Postgraduate Scholarship 513934. Support for Rodney Scott was in part from NBN Children’s Cancer Research Fund.

Conflict of interest

The authors declare that they have no conflict of interest.

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Correspondence to Elizabeth Milne.

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Greenop, K.R., Peters, S., Fritschi, L. et al. Exposure to household painting and floor treatments, and parental occupational paint exposure and risk of childhood brain tumors: results from an Australian case–control study. Cancer Causes Control 25, 283–291 (2014). https://doi.org/10.1007/s10552-013-0330-x

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  • DOI: https://doi.org/10.1007/s10552-013-0330-x

Keywords

  • Child
  • Brain tumors
  • Paint
  • Case–control
  • Solvents
  • Occupational exposures
  • Household exposures