A case–control study of lifetime light intensity physical activity and breast cancer risk

Abstract

Purpose

Physical activity reduces breast cancer risk, although most evidence is for activity in the moderate-to-vigorous intensity range. The effect of light intensity physical activity (LIPA) is unknown. We aimed to determine the association between self-reported lifetime LIPA and pre- and post-menopausal breast cancer risk. Our secondary objective was to analyze risk stratified by estrogen and progesterone tumor receptor status.

Methods

Data were from a case–control study of 1,110 incident breast cancer cases (388 pre-menopausal; 722 post-menopausal) and 1,172 controls (442 pre-menopausal; 730 post-menopausal) recruited at two Canadian sites. Lifetime leisure-time, household, and occupational physical activity and covariates were assessed by questionnaire. Mean minutes per day of LIPA for each of the age periods 12–17, 18–34, 35–49, ≥50, and the total lifetime were calculated. Odds ratios were calculated using unconditional logistic regression for overall breast cancer risk and using polytomous logistic regression for estrogen receptor (ER)/progesterone receptor (PR)-defined tumor subtypes and were adjusted for moderate-to-vigorous physical activity and other confounders.

Results

LIPA was not associated with breast cancer risk at any age period across the life course: odds ratio (OR) = 0.81; 95 % CI 0.53–1.24 for pre-menopausal women and OR = 0.87; 95 % CI 0.64–1.19 for post-menopausal women in the highest vs. lowest categories of total lifetime LIPA. No heterogeneity in risk by ER/PR tumor status was observed.

Conclusions

Our results suggest that light intensity physical activity is not associated with breast cancer risk reduction. This finding is important for physical activity recommendations for breast cancer prevention.

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References

  1. 1.

    WCRF/AICR (2007) Food, Nutrition, Physical activity, and the risk of cancer: a global perspective. Washington DC, pp 198–209

  2. 2.

    Monninkhof E, Elias S, Vlems F, Van der Tweel I, Schiut A, Voskuil DW, van Leeuwen FE (2007) Physical activity and breast cancer: a systematic review. Epidemiology 18:137–157

    PubMed  Article  Google Scholar 

  3. 3.

    Lynch BM, Neilson HK, Friedenreich CM (2011) Physical activity and breast cancer prevention. In: Courneya KS, Friedenreich CM (eds) Physical activity and cancer. Springer-Verlag, Berlin, pp 13–42

    Google Scholar 

  4. 4.

    Norton K, Norton L, Sadgrove D (2010) Position statement on physical activity and exercise intensity terminology. J Sci Med Sport 13:496–502

    PubMed  Article  Google Scholar 

  5. 5.

    Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O’Brien WL, Bassett DR Jr, Schmitz KH, Emplaincourt PO, Jacobs DR Jr, Leon AS (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sport Exerc 32:S498–S516

    CAS  Article  Google Scholar 

  6. 6.

    Owen N, Healy GN, Matthews CE, Dunstan DW (2010) Too much sitting: the population health science of sedentary behavior. Exerc Sport Sci Rev 38:105–113

    PubMed Central  PubMed  Article  Google Scholar 

  7. 7.

    Lynch BM (2010) Sedentary behavior and cancer: a systematic review of the literature and proposed biological mechanisms. Cancer Epidemiol Biomarkers Prev 19:2691–2709

    PubMed  Article  Google Scholar 

  8. 8.

    Friedenreich CM, Courneya KS, Bryant HE (2001) Relation between intensity of physical activity and breast cancer risk reduction. Med Sci Sport Exerc 33:1538–1545

    CAS  Article  Google Scholar 

  9. 9.

    Tehard B, Friedenreich CM, Oppert J-M, Clavel-Chapelon F (2006) Effect of physical activity on women at increased risk of breast cancer: results from the E3 N cohort study. Cancer Epidemiol Biomarkers Prev 15:57–64

    PubMed  Article  Google Scholar 

  10. 10.

    Peters TM, Moore SC, Gierach GL, Wareham NJ, Ekelund U, Hollenbeck AR, Schatzkin A, Leitzmann MF (2009) Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study. BMC Cancer 9:1–14

    Article  Google Scholar 

  11. 11.

    Adams SA, Matthews CE, Hebert JR, Moore CG, Cunningham JE, Shu X-O, Fulton J, Gao Y, Zheng W (2006) Association of physical activity with hormone receptor status: the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev 15:1170–1178

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  12. 12.

    Steindorf K, Ritte R, Eomois P–P, Lukanova A, Tjonneland A, Johnsen NF, Overvad K, Østergaard JN, Clavel-Chapelon F, Fournier A, Dossus L, Teucher B et al (2013) Physical activity and risk of breast cancer overall and by hormone receptor status: the European prospective investigation into cancer and nutrition. Int J Cancer 132:1667–1678

    CAS  PubMed  Article  Google Scholar 

  13. 13.

    Suzuki R, Iwasaki M, Yamamoto S, Inoue M, Sasazuki S (2011) Leisure-time physical activity and breast cancer risk defined by estrogen and progesterone receptor status–The Japan Public Health Center-based Prospective Study. Prev Med 52:227–233

    PubMed  Google Scholar 

  14. 14.

    Schmidt ME, Steindorf K, Mutschelknauss E, Slanger T, Kropp S, Obi N, Flesch-Janys D, Chang-Claude J (2008) Physical activity and postmenopausal breast cancer: effect modification by breast cancer subtypes and effective periods in life. Cancer Epidemiol Biomarkers Prev 17:3402–3410

    PubMed  Article  Google Scholar 

  15. 15.

    Kobayashi L, Janssen I, Richardson H, Lai A, Spinelli J, Aronson KJ (2013) Moderate-to-vigorous intensity physical activity across the life course and risk of pre-and post-menopausal breast cancer. Breast Cancer Res Treat 139:851–861

    CAS  PubMed  Article  Google Scholar 

  16. 16.

    Grundy A, Richardson H, Burstyn I, Lohrisch C, SenGupta S, Lai A, Lee D, Spinelli JJ, Aronson KJ (2013) Increased risk of breast cancer associated with long-term shift work in Canada. Occup Environ Med (in press)

  17. 17.

    Friedenreich C, Courneya K, Bryant H (1998) The lifetime total physical activity questionnaire: development and reliability. Med Sci Sport Exerc 30:266–274

    CAS  Article  Google Scholar 

  18. 18.

    Rothman K, Greenland S (2008) Introduction to stratified analysis. In: Rothman K, Greenland S, Lash TL (eds) Modern epidemiology, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 258–282

    Google Scholar 

  19. 19.

    Garriguet D, Colley RC (2012) Daily patterns of physical activity among Canadians. Health Rep 23:1–6

    Google Scholar 

  20. 20.

    Friedenreich CM, Woolcott CG, McTiernan A, Terry T, Brant R, Ballard-Barbash R, Irwin ML, Jones CA, Boyd NF, Yaffe MJ, Campbell KL, McNeely ML et al (2011) Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial. Int J Obes 35:427–435

    CAS  Article  Google Scholar 

  21. 21.

    Friedenreich C, Woolcott CG, McTiernan A, Ballard-Barbash R, Brant RF, Stanczyk FZ, Terry T, Boyd NF, Yaffe MJ, Irwin ML, Jones CA, Yasui Y et al (2010) Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol 28:1458–1466

    CAS  PubMed  Article  Google Scholar 

  22. 22.

    McTiernan A, Tworoger SS, Ulrich CM, Yasui Y, Irwin ML, Rajan KB, Sorensen B, Rudolph RE, Bowen D, Stanczyk FZ, Potter JD, Schwartz RS (2004) Effect of exercise on serum estrogens in postmenopausal women: a 12 month randomized clinical trial. Cancer Res 64:2923–2928

    CAS  PubMed  Article  Google Scholar 

  23. 23.

    Friedenreich CM, Neilson HK, Woolcott CG, McTiernan A, Wang Q, Ballard-Barbash R, Jones CA, Stanczyk FZ, Brant RF, Yasui Y, Irwin ML, Campbell KL et al (2011) Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocr-Relat Cancer 18:357–369

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  24. 24.

    Lynch BM, Friedenreich CM, Vallance JK, Eakin EG, Owen N (2011) Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003–2006). Breast Cancer Res Treat 130:183–194

    PubMed  Article  Google Scholar 

  25. 25.

    Friedenreich CM (2004) Physical activity and breast cancer risk: the effect of menopausal status. Exerc Sport Sci Rev 32:180–184

    PubMed  Article  Google Scholar 

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Acknowledgments

The MEBC study is funded by a grant from the Canadian Institutes of Health Research. The authors thank Dr. Chris Bajdik for his contributions to study design and conduct; Derrick Lee, Dr. Matt Parkinson, and Dr. Anne Grundy for their assistance with data management; and Dr. Christine Friedenreich for permission to adapt the study questionnaire. Lindsay Kobayashi was supported by an Ontario Graduate Scholarship from the Ontario Ministry of Training, Colleges, and Universities and a studentship from the Queen’s University Terry Fox Foundation Training Program in Transdisciplinary Cancer Research in Partnership with CIHR.

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Correspondence to Kristan J. Aronson.

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Kobayashi, L.C., Janssen, I., Richardson, H. et al. A case–control study of lifetime light intensity physical activity and breast cancer risk. Cancer Causes Control 25, 133–140 (2014). https://doi.org/10.1007/s10552-013-0312-z

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Keywords

  • Physical activity
  • Breast cancer
  • Women
  • Case–control
  • Menopausal status
  • Prevention