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Coffee and risk of prostate cancer incidence and mortality in the Cancer of the Prostate in Sweden Study

Cancer Causes & Control volume 24, pages 1575–1581 (2013)Cite this article

Abstract

Purpose

Coffee intake has recently been associated with significantly lower risk of lethal and advanced prostate cancer in a US population.

Methods

We studied the association between coffee and prostate cancer risk in the population-based case–control study Cancer of the Prostate in Sweden. Dietary data were available for 1,499 cases and 1,112 controls. We calculated odds ratios (ORs) for the risk of prostate cancer in high versus low categories of coffee intake using logistic regression. We studied overall prostate cancer risk as well as risk of fatal, advanced, localized, high-grade, grade 7, and low-grade disease.

Results

Mean coffee intake was 3.1 cups per day among both cases and controls. Coffee intake was not associated with overall prostate cancer risk. Risk of fatal prostate cancer was inversely, but not statistically significantly, associated with coffee intake, with an odds ratio of 0.64 [95 % confidence interval (CI) 0.34–1.19, p value for linear trend = 0.81] for men consuming greater than 5 cups per day compared to men drinking less than 1 cup per day. The highest intake of coffee was associated non-significantly with lower risk of advanced disease (OR = 0.73, 95 % CI 0.41–1.30, p trend = 0.98) and associated significantly with lower risk of high-grade cancer (Gleason 8–10; OR = 0.50, 95 % CI 0.26–0.98, p trend = 0.13). Risk of localized, grade 7, and low-grade cancers was not associated with coffee intake.

Conclusions

This study provides some support of an inverse association between coffee and lethal and high-grade prostate cancer.

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Acknowledgments

This work was supported by the Swedish Cancer Society. The funding organization had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA

    Kathryn M. Wilson, Hans-Olov Adami & Lorelei A. Mucci

  2. Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Kathryn M. Wilson & Lorelei A. Mucci

  3. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    Katarina Bälter, Elisabeth Möller, Hans-Olov Adami & Henrik Grönberg

  4. Örebro University Hospital, Örebro, Sweden

    Ove Andrén & Swen-Olof Andersson

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  1. Kathryn M. Wilson
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Correspondence to Kathryn M. Wilson.

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Wilson, K.M., Bälter, K., Möller, E. et al. Coffee and risk of prostate cancer incidence and mortality in the Cancer of the Prostate in Sweden Study. Cancer Causes Control 24, 1575–1581 (2013). https://doi.org/10.1007/s10552-013-0234-9

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  • DOI: https://doi.org/10.1007/s10552-013-0234-9

Keywords

  • Coffee
  • Diet
  • Prostate cancer