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Consumption of sugary foods and drinks and risk of endometrial cancer

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Abstract

Consumption of foods high in sugar promotes insulin production, which has been linked to endometrial carcinogenesis. We evaluated the impact of dietary intake of sugary foods and beverages, as well as added sugar and total sugar on endometrial cancer risk in a population-based case–control study, including 424 cases and 398 controls. Participants completed an interview and food frequency questionnaire, and provided self-recorded waist and hip measurements. Women in the highest quartile of added sugar intake had significantly increased endometrial cancer risk (OR = 1.84, 95 % CI 1.16–2.92). Among women with waist-to-hip ratio ≥0.85, risk was significantly higher for the highest versus lowest tertile of added sugar intakes (OR = 2.50, 95 % CI 1.38–4.52). The association with added sugar also became stronger when analyses were restricted to never users of hormone replacement therapy (OR = 2.03; 95 % CI 1.27–3.26, for highest versus lowest tertile). There was little evidence of effect modification by body mass index or physical activity. Given the high prevalence of intake of sugary foods and drinks in Western populations, additional research is warranted to confirm our findings on endometrial cancer.

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References

  1. American Cancer Society (2012) Cancer facts and figures. American Cancer Society, Atlanta

    Google Scholar 

  2. Key TJ, Pike MC (1988) The dose-effect relationship between ‘unopposed’ oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk. Br J Cancer 57:205–212

    Article  PubMed  CAS  Google Scholar 

  3. DeVivo I, Persson I, Adami H-O (2008) Endometrial cancer. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 468–493

    Chapter  Google Scholar 

  4. Augustin LS, Franceschi S, Jenkins DJA, Kendall CWC, La Vecchia C (2002) Glycemic index in chronic disease: a review. Eur J Clin Nutr 56:1049–1071

    Article  PubMed  CAS  Google Scholar 

  5. Mulholland HG, Murray LJ, Cardwell CR, Cantwell MM (2008) Dietary glycaemic index, glycaemic load and endometrial and ovarian cancer risk: a systematic review and meta-analysis. Br J Cancer 99:434–441

    Article  PubMed  CAS  Google Scholar 

  6. Galeone C, Augustin LS, Filomeno M et al (2013) Dietary glycemic index, glycemic load, and the risk of endometrial cancer: a case-control study and meta-analysis. Eur J Cancer Prev 22:38–45

    Article  PubMed  CAS  Google Scholar 

  7. Cust AE, Slimani N, Kaaks R et al (2007) Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort. Am J Epidemiol 166:912–923

    Article  PubMed  Google Scholar 

  8. Calle EE, Thun MJ (2004) Obesity and cancer. Oncogene 23:6365–6378

    Article  PubMed  CAS  Google Scholar 

  9. Kaaks R, Lukanova A, Kurzer MS (2002) Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev 11:1531–1543

    PubMed  CAS  Google Scholar 

  10. Welsh JA, Sharma AJ, Grellinger L, Vos MB (2011) Consumption of added sugars is decreasing in the United States. Am J Clin Nutr 94:726–734

    Article  PubMed  CAS  Google Scholar 

  11. US Department of Agriculture and US Department of Health and Human Services (2010) Dietary guidelines for Americans 7th edn. US Government Printing Office, Washington

    Google Scholar 

  12. World Cancer Research Fund, American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. American Cancer Institute for Cancer Research, Washington

    Google Scholar 

  13. Johnson RK, Appel LJ, Brands M et al (2009) Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation 120:1011–1020

    Article  PubMed  CAS  Google Scholar 

  14. Welsh JA, Cunningham SA (2011) The role of added sugars in pediatric obesity. Pediatr Clin North Am 58:1455–1466

    Article  PubMed  Google Scholar 

  15. Bray GA, Nielsen SJ, Popkin BM (2004) Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79:537–543

    PubMed  CAS  Google Scholar 

  16. Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough M (2007) The Association between Food, Nutrition, and Physical Activity and the Risk of Endometrial Cancer and Underlying Mechanisms. Second Report on Food, Nutrition, Physical Activity and the Prevention of Cancer. World Cancer Research Fund International/American Institute for Cancer Research

  17. Friberg E, Wallin A, Wolk A (2011) Sucrose, high-sugar foods and risk of endometrial cancer–a population-based cohort study. Cancer Epidemiol Biomarkers Prev 20(9):1831–1837

    Article  PubMed  CAS  Google Scholar 

  18. Silvera SAN, Rohan TE, Jain M, Terry PD, Howe GR, Miller AB (2005) Glycaemic index, glycaemic load and risk of endometrial cancer: a prospective cohort study. Public Health Nutr 8:912–919

    Article  PubMed  Google Scholar 

  19. Tasevska N, Jiao L, Cross AJ et al (2011) Sugars in diet and risk of cancer in the NIH-AARP Diet and Health Study. Int J Cancer 130:159–169

    Article  PubMed  Google Scholar 

  20. Bandera EV, Williams-King MG, Sima C et al (2010) Coffee and tea consumption and endometrial cancer risk in a population-based study in New Jersey. Cancer Causes Control 21:1467–1473

    Article  PubMed  Google Scholar 

  21. Chandran U, Bandera EV, Williams-King MG et al (2010) Adherence to the dietary guidelines for Americans and endometrial cancer risk. Cancer Causes Control 21:1895–1904

    Article  PubMed  Google Scholar 

  22. Goodman MT, Hankin JH, Wilkens LR et al (1997) Diet, body size, physical activity, and the risk of endometrial cancer. Cancer Res 57:5077–5085

    PubMed  CAS  Google Scholar 

  23. McCann SE, Freudenheim JL, Marshall JR, Brasure JR, Swanson MK, Graham S (2000) Diet in the epidemiology of endometrial cancer in western New York (United States). Cancer Causes Control 11:965–974

    Article  PubMed  CAS  Google Scholar 

  24. Potischman N, Swanson CA, Brinton LA et al (1993) Dietary associations in a case-control study of endometrial cancer. Cancer Causes Control 4:239–250

    PubMed  CAS  Google Scholar 

  25. Shu XO, Zheng W, Potischman N et al (1993) A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People’s Republic of China. Am J Epidemiol 137:155–165

    PubMed  CAS  Google Scholar 

  26. Biel RK, Friedenreich CM, Csizmadi I et al (2011) Case-control study of dietary patterns and endometrial cancer risk. Nutr Cancer 63:673–686

    Article  PubMed  CAS  Google Scholar 

  27. Levi F, Franceschi S, Negri E, La Vecchia C (1993) Dietary factors and the risk of endometrial cancer. Cancer 71:3575–3581

    Article  PubMed  CAS  Google Scholar 

  28. Lucenteforte E, Talamini R, Montella M et al (2008) Macronutrients, fatty acids and cholesterol intake and endometrial cancer. Ann Oncol 19:168–172

    Article  PubMed  CAS  Google Scholar 

  29. Petridou E, Kedikoglou S, Koukoulomatis P, Dessypris N, Trichopoulos D (2002) Diet in relation to endometrial cancer risk: a case-control study in Greece. Nutrition Cancer 44:16–22

    Article  Google Scholar 

  30. Salazar-Martinez E, Lazcano-Ponce E, Sanchez-Zamorano LM, Gonzalez-Lira G, Escudero-De Los Rios P, Hernandez-Avila M (2005) Dietary factors and endometrial cancer risk. Results of a case–control study in Mexico. Int J Gynecol Cancer 15:938–945

    Article  PubMed  CAS  Google Scholar 

  31. Tzonou A, Lipworth L, Kalandidi A et al (1996) Dietary factors and the risk of endometrial cancer: a case–control study in Greece. Br J Cancer 73:1284–1290

    Article  PubMed  CAS  Google Scholar 

  32. Zemla B, Guminski S, Banasik R (1986) Study of risk factors in invasive cancer of the corpus uteri. Neoplasma 33:621–629

    PubMed  CAS  Google Scholar 

  33. Zemla B, Guminski S, Franek K, Kolosza Z, Banasik R (1991) Etiological factors in invasive corpus uteri carcinoma. Neoplasma 38:157–163

    PubMed  CAS  Google Scholar 

  34. Bandera EV, Williams MG, Sima C et al (2009) Phytoestrogen consumption and endometrial cancer risk: a population-based case-control study in New Jersey. Cancer Causes Control 20:1117–1127

    Article  PubMed  Google Scholar 

  35. Fortuny J, Sima C, Bayuga S et al (2009) Risk of endometrial cancer in relation to medical conditions and medication use. Cancer Epidemiol Biomarkers Prev 18:1448–1456

    Article  PubMed  Google Scholar 

  36. Olson SH, Orlow I, Bayuga S et al (2008) Variants in hormone biosynthesis genes and risk of endometrial cancer. Cancer Causes Control 19:955–963

    Article  PubMed  Google Scholar 

  37. Boucher B, Cotterchio M, Kreiger N, Nadalin V, Block T, Block G (2006) Validity and reliability of the Block98 food-frequency questionnaire in a sample of Canadian women. Public Health Nutr 9:84–93

    Article  PubMed  Google Scholar 

  38. U.S. Department of Agriculture; Agricultural Research Service (2011) USDA National Nutrient Database for Standard Reference, Release 24. Nutrient Data Laboratory Home Page, http://www.ars.usda.gov/Services/docs.htm?docid=22808

  39. US Food and Drug Administration (2011) Title 21- Food and Drugs, Chapter 1- Food and Drug Administration, Department of Health and Human Services, Subchapter B- Food for Human Consumption, Part 101- Food Labeling, Section 101.12-Reference amounts customarily consumed per eating occasion. In: Food and Drug Administration Department of Health and Human Services., ed. Code of Federal Regulations Title 21. USA: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=101.12

  40. United States Department of Agriculture (2006) USDA database for the added sugar content of selected foods. USDA Agricultural Research Service, Beltsville

    Google Scholar 

  41. Willett W (1990) Nutritional Epidemiology, 1st edn. Oxford University Press, England

    Google Scholar 

  42. Chun OK, Chung CE, Wang Y, Padgitt A, Song WO (2010) Changes in intakes of total and added sugar and their contribution to energy intake in the U.S. Nutrients 2:834–854

    Article  PubMed  CAS  Google Scholar 

  43. Larsson SC, Friberg E, Wolk A (2007) Carbohydrate intake, glycemic index and glycemic load in relation to risk of endometrial cancer: a prospective study of Swedish women. Int J Cancer 120:1103–1107

    Article  PubMed  CAS  Google Scholar 

  44. Cust AE, Armstrong BK, Friedenreich CM, Slimani N, Bauman A (2007) Physical activity and endometrial cancer risk: a review of the current evidence, biologic mechanisms and the quality of physical activity assessment methods. Cancer Causes Control 18:243–258

    Article  PubMed  Google Scholar 

  45. Folsom AR, Demissie Z, Harnack L (2003) Glycemic index, glycemic load, and incidence of endometrial cancer: the Iowa women’s health study: the Iowa women’s health study. Nutrition Cancer 46:119–124

    Article  Google Scholar 

Download references

Acknowledgments

We thank the research staff who were involved in this study at Memorial Sloan-Kettering Cancer Center (Sharon Bayuga, Katherine Pulick, Silvia Brendel, Nora Geraghty, June Kittredge, Elinor Miller, Louise Salant, Mathilde Saxon, Elizabeth Ward, Doreen Wass, Kay Yoon), the New Jersey Department of Health and Senior Services personnel (Sandy Wilcox, Tara Blando, Joan Kay, Betsy Kohler, Kevin Masterson, and Helen Weiss), as well as all the participants who generously donated their time to the study. This work was funded by the National Cancer Institute (K07 CA095666, R01CA83918, K22CA138563, and P30CA072720).

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Correspondence to Elisa V. Bandera.

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King, M.G., Chandran, U., Olson, S.H. et al. Consumption of sugary foods and drinks and risk of endometrial cancer. Cancer Causes Control 24, 1427–1436 (2013). https://doi.org/10.1007/s10552-013-0222-0

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  • DOI: https://doi.org/10.1007/s10552-013-0222-0

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