Exposure to pesticides and the risk of childhood brain tumors
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Previous research has suggested positive associations between parental or childhood exposure to pesticides and risk of childhood brain tumors (CBT). This Australian case–control study of CBT investigated whether exposures to pesticides before pregnancy, during pregnancy and during childhood, were associated with an increased risk.
Cases were recruited from 10 pediatric oncology centers, and controls by random-digit dialing, frequency matched on age, sex, and State of residence. Exposure data were collected by written questionnaires and telephone interviews. Data were analyzed by unconditional logistic regression.
The odds ratios (ORs) for professional pest control treatments in the home in the year before the index pregnancy, during the pregnancy, and after the child’s birth were 1.54 (95 % confidence interval (CI): 1.07, 2.22), 1.52 (95 % CI: 0.99, 2.34) and 1.04 (95 % CI: 0.75, 1.43), respectively. ORs for treatments exclusively before pregnancy and during pregnancy were 1.90 (95 % CI: 1.08, 3.36) and 1.02 (95 % CI: 0.35, 3.00), respectively. The OR for the father being home during the treatment was 1.79 (95 % CI: 0.85, 3.80). The OR for paternal occupational exposure in the year before the child’s conception was 1.36 (95 % CI: 0.66, 2.80). ORs for prenatal home pesticide exposure were elevated for low- and high-grade gliomas; effect estimates for other CBT subtypes varied and lacked precision.
These results suggest that preconception pesticide exposure, and possibly exposure during pregnancy, is associated with an increased CBT risk. It may be advisable for both parents to avoid pesticide exposure during this time.
KeywordsBrain tumors Case–control studies Child Cancer Pesticides Insecticides
The authors acknowledge the contribution made by our clinical co-investigators who recruited and cared for study patients at each participating hospital: Nicholas Gottardo (Princess Margaret Hospital, TICHR); John Heath and Elizabeth Smibert (Royal Children’s Hospital, Melbourne); Peter Downie (Monash Medical Center, Melbourne); Tim Hassell and Ross Pinkerton (Royal Children’s Hospital Brisbane); Maria Kirby (Women’s and Children’s Hospital, Adelaide); Stewart Kellie and Luciano dalla Pozza (Westmead Hospital); Frank Alvaro (John Hunter Hospital, Newcastle); Richard Cohn (Sydney Children’s Hospital) and John Dauberton (Royal Hobart Hospital). The authors also acknowledge the Clinical Research Associates at each hospital, and the study coordinators: Jackie Mansour, Somer Dawson, Tamika Heiden, and Helen Bailey; and Peter Cosgrove for programming the estimation of supplement intake from the food frequency questionnaires. The National Health and Medical Research Council (NHMRC) funded Aus-ALL (Grant number: 254539) and Aus-CBT (Grant number: 404089). Elizabeth Milne and Lin Fritschi were supported by NHMRC Fellowships, and Helen Bailey was supported by NHMRC Post Graduate Scholarship 513934. Support for Rodney Scott was in part from NBN Children’s Cancer Research Fund.
The Aus-CBT consortium conducted the study, and the Telethon Institute for Child Health Research (TICHR), University of Western Australia, was the coordinating center. Bruce Armstrong (Sydney School of Public Health, University of Sydney), Elizabeth Milne, Nicholas de Klerk, Carol Bower, Peter Dallas (TICHR), Frank van Bockxmeer (Royal Perth Hospital, University of WA), Rodney Scott and John Attia (University of Newcastle), Lin Fritschi (WA Institute for Medical Research), Lesley Ashton, Michelle Haber and Murray Norris (Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Center, UNSW), Margaret Miller (Edith Cowan University), and Judith Thompson (WA Cancer Registry) were the research investigators.
Conflict of interest
- 2.U.S. Environmental Protection Agency (2009) Chemicals evaluated for carcinogenic potential. Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington, DCGoogle Scholar
- 3.Australian Pesticides and Veterinary Medicines Authority Public Chemical Registration Information System: PUBCRIS. http://services.apvma.gov.au/PubcrisWebClient/welcome.do. Last accessed 23 Aug 2012
- 4.Whyatt RM, Barr DB, Camann DE, Kinney PL, Barr JR, Andrews HF, Hoepner LA, Garfinkel R, Hazi Y, Reyes A, Ramirez J, Cosme Y, Perera FP (2003) Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environ Health Perspect 111:749–756PubMedCrossRefGoogle Scholar
- 5.Ostrea EM Jr, Bielawski DM, Posecion NC Jr, Corrion M, Villanueva-Uy E, Bernardo RC, Jin Y, Janisse JJ, Ager JW (2009) Combined analysis of prenatal (maternal hair and blood) and neonatal (infant hair, cord blood and meconium) matrices to detect fetal exposure to environmental pesticides. Environ Res 109:116–122PubMedCrossRefGoogle Scholar
- 7.Freeman NC, Jimenez M, Reed KJ, Gurunathan S, Edwards RD, Roy A, Adgate JL, Pellizzari ED, Quackenboss J, Sexton K, Lioy PJ (2001) Quantitative analysis of children’s microactivity patterns: the Minnesota Children’s Pesticide Exposure Study. J Expo Anal Environ Epidemiol 11:501–509PubMedCrossRefGoogle Scholar
- 9.Efird JT, Holly EA, Preston-Martin S, Mueller BA, Lubin F, Filippini G, Peris-Bonet R, McCredie M, Cordier S, Arslan A, Bracci PM (2003) Farm-related exposures and childhood brain tumours in seven countries: results from the SEARCH International Brain Tumour Study. Paediatr Perinat Epidemiol 17:201–211PubMedCrossRefGoogle Scholar
- 22.Milne E, Royle JA, Miller M, Bower C, de Klerk N, Bailey H, Van Bockxmeer F, Attia J, Scott RJ, Norris MD, Haber M, Thompson J, Fritschi L, Marshall G, Armstrong BK (2009) Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring. Int J Cancer 126:2690–2699Google Scholar
- 23.Australian Bureau of Statistics (2008) Information paper: an introduction to socio-economic indexes, 2006 Cat. no. 2039.0. Commonwealth of Australia. http://www.ausstats.abs.gov.au/Ausstats/subscriber.nsf/0/D729075E079F9FDECA2574170011B088/$File/20390_2006.pdf. Accessed 13 Jan 2012
- 30.Commonwealth Scientific and Industrial Research Organisation (CSIRO) (2009) Fact sheet: termite or ‘white ant treatment’ and prevention. CSIRO, Australia. http://www.csiro.au/en/Outcomes/Safeguarding-Australia/Termites/Termite-pest-management-and-control.aspx. Accessed 16 Jan 2013
- 31.Office of Chemical Safety; Australian Government Department of Health and Ageing (2007) Termite protection: available treatments and hazard information about termiticides. Commonwealth of Australia. http://www.health.gov.au/internet/main/publishing.nsf/Content/B7B393FD711BD33DCA25757500077AAD/$File/Termite%20Protection%20Available%20Treatments%20and%20Hazard%20Information%20about%20Termites.pdf. Accessed 2 April 2013
- 32.Australian Bureau of Statistics (2008) Western Australia statistical indicators, Sept 2008. Cat. no: 1367.5. ABS, Commonwealth of Australia. http://www.abs.gov.au/AUSSTATS/abs@.nsf/DetailsPage/1367.5Sep%202008. Accessed Sept 2012