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Nutrient-based dietary patterns of head and neck squamous cell cancer: a factor analysis in Uruguay

Cancer Causes & Control volume 24, pages 1167–1174 (2013)Cite this article

Abstract

Objective

The aim of this study was to investigate the association between nutrient-based dietary patterns and squamous cell cancers of the head and neck.

Methods

We used a case–control study which included 548 cases and 548 controls. From these participants, we derived 23 nutrients and they were then submitted to a factorability analysis in order to conduct a principal component factor analysis.

Results

We were able to identify four nutrient-derived patterns. The first pattern (meat-based pattern) was positively associated with squamous cell cancer of the head and neck (OR 2.85, 95 % CI 1.81–4.15), whereas the third pattern (fruit-based) was strongly protective (OR 0.43, 95 % CI 0.27–0.63). The other nutrient patterns were also significantly associated with head and neck squamous cell carcinoma with minor ORs.

Conclusion

Both patterns suggest that red meat and fruits are major factors in the etiology of head and neck squamous cell cancer, replicating previous studies in the field.

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Acknowledgments

This study was funded by the International Agency for Research on Cancer, Lyon, France.

Conflict of interest

The authors declare absence of conflicts of interest.

Author information

Affiliations

  1. Epidemiology Group, Department of Pathology, School of Medicine, Avenida Brasil 3080 department 402, 11300, Montevideo, Uruguay

    Hugo Deneo-Pellegrini, Eduardo De Stefani, Gisele Acosta, María Mendilaharsu, Cecilia Silva & María E. Luaces

  2. The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA

    Paolo Boffetta

  3. Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA

    Pelayo Correa

  4. Department of Epidemiology, University of Maldonado, Maldonado, Uruguay

    Alvaro L. Ronco

Authors
  1. Hugo Deneo-Pellegrini
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  2. Paolo Boffetta
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  3. Eduardo De Stefani
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  4. Pelayo Correa
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  5. Alvaro L. Ronco
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  6. Gisele Acosta
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  7. María Mendilaharsu
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  8. Cecilia Silva
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  9. María E. Luaces
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Corresponding author

Correspondence to Eduardo De Stefani.

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Deneo-Pellegrini, H., Boffetta, P., De Stefani, E. et al. Nutrient-based dietary patterns of head and neck squamous cell cancer: a factor analysis in Uruguay. Cancer Causes Control 24, 1167–1174 (2013). https://doi.org/10.1007/s10552-013-0196-y

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  • DOI: https://doi.org/10.1007/s10552-013-0196-y

Keywords

  • Factor analysis
  • Dietary patterns
  • Oral and pharyngeal cancer
  • Laryngeal cancer
  • Nutrients