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Prostate cancer mortality and birth or adult residence in the southern United States

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Abstract

Purpose

Although there are few confirmed risk factors for prostate cancer (PCa), mortality rates are known to vary geographically across the United States. PCa mortality is higher among black and younger white men in a band of states spanning from Washington DC to Louisiana (the “PCa belt”). This study assessed the associations of birth and adult residence in the PCa belt with PCa mortality among black and white men and trends in these associations over time.

Methods

PCa-specific mortality rates in 1980, 1990, and 2000 for black and white men born in the continental US, aged 40–89, were calculated by linking national mortality records with population data based on birth state, state of residence at the census, race, and age. PCa belt (Washington DC, Virginia, North Carolina, South Carolina, Georgia, Mississippi, Alabama, and Louisiana) birth was cross-classified against PCa belt adult residence.

Results

Black men born in the PCa belt had elevated PCa mortality in 1980, 1990, and 2000. Associations were independent of adult residence in the PCa belt. For example, in 2000, black men aged 65–89 who were born in the PCa belt but no longer lived there in adulthood had an odds ratio of 1.19 (1.14–1.24) for PCa mortality compared to black men born and residing outside the PCa belt. The PCa belt was not associated with PCa mortality among whites.

Conclusions

Geographically patterned childhood exposures, for example, differences in social or environmental conditions, or behavioral norms, may influence PCa mortality.

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Acknowledgments

G. D. D and J. T. C. are partially supported by 1 P50 CA1 48596-01. M. M. G. is supported by the Program on the Global Demography of Aging at Harvard University (an NIA supported program).

Conflict of interest

No financial disclosures were reported by the authors of this paper.

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Authors and Affiliations

  1. Centre de recherche du Centre Hospitalier de l’Université de Montréal, 3875 Saint-Urbain, Office # 302, Montreal, QC, H2W 1V1, Canada

    Geetanjali D. Datta

  2. Département de médecine sociale et préventive, Université de Montréal, Montreal, QC, Canada

    Geetanjali D. Datta

  3. Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA, USA

    M. Maria Glymour, Anna Kosheleva & Jarvis T. Chen

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  1. Geetanjali D. Datta
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Correspondence to Geetanjali D. Datta.

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Datta, G.D., Glymour, M.M., Kosheleva, A. et al. Prostate cancer mortality and birth or adult residence in the southern United States. Cancer Causes Control 23, 1039–1046 (2012). https://doi.org/10.1007/s10552-012-9970-5

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  • DOI: https://doi.org/10.1007/s10552-012-9970-5

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