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Total and individual antioxidant intake and endometrial cancer risk: results from a population-based case–control study in New Jersey

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Abstract

We evaluated the role of total dietary antioxidant capacity and of individual antioxidants on endometrial cancer risk in a population-based case–control study in New Jersey, including 417 cases and 395 controls. Dietary intake was ascertained using a food-frequency questionnaire (FFQ), and total antioxidant capacity (TAC) intake was estimated using the USDA Oxygen Radical Absorbance Capacity (ORAC) database and the University of Oslo’s Antioxidant Food Database (AFD) and FFQ-derived estimates of intake. Odds ratios and 95 % confidence intervals were derived using multivariate logistic regression controlling for major endometrial cancer risk factors. Using the ORAC database, after adjusting for major covariates, we found decreased risks for the highest tertile of total phenolic intake compared with the lowest (OR: 0.62; 95 % CI: 0.39–0.98). There was no association for TAC intake based on the AFD, which utilized the ferric-reducing ability of plasma (FRAP) assay to assess antioxidant capacity. There was no strong evidence for an association with intake of any of the individual antioxidants. Our findings suggest that total phenolic consumption may decrease endometrial cancer risk.

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Acknowledgments

We thank the research staff who were involved in this study at Memorial Sloan-Kettering Cancer Center (Sharon Bayuga, Katherine Pulick, Silvia Brendel, Nora Geraghty, June Kittredge, Elinor Miller, Louise Salant, Mathilde Saxon, Elizabeth Ward, Doreen Wass, and Kay Yoon), the New Jersey Department of Health and Senior Services personnel (Sandy Wilcox, Tara Blando, Joan Kay, Betsy Kohler, Kevin Masterson, and Helen Weiss), as well as all the participants who generously donated their time to the study. This work was funded in part by NIH-K22CA138563 and R01CA83918.

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Authors and Affiliations

  1. The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany St., New Brunswick, NJ, 08903, USA

    Dina Gifkins, Kitaw Demissie, Shou-En Lu & Elisa V. Bandera

  2. School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA

    Dina Gifkins, Kitaw Demissie, Shou-En Lu & Elisa V. Bandera

  3. Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Sara H. Olson

  4. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA

    Ah-Ng Tony Kong

Authors
  1. Dina Gifkins
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  2. Sara H. Olson
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  3. Kitaw Demissie
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  4. Shou-En Lu
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  5. Ah-Ng Tony Kong
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  6. Elisa V. Bandera
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Corresponding author

Correspondence to Elisa V. Bandera.

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Gifkins, D., Olson, S.H., Demissie, K. et al. Total and individual antioxidant intake and endometrial cancer risk: results from a population-based case–control study in New Jersey. Cancer Causes Control 23, 887–895 (2012). https://doi.org/10.1007/s10552-012-9958-1

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  • DOI: https://doi.org/10.1007/s10552-012-9958-1

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