Skip to main content
SpringerLink
Log in

Association of colorectal adenoma with components of metabolic syndrome

  • Original paper
  • Published:
Cancer Causes & Control Aims and scope Submit manuscript

Abstract

Purpose

Recently, some studies have shown that diabetes mellitus and metabolic syndrome increase the risk of colorectal neoplasms. Although the mechanism is not known, those have been proposed to contribute to this phenomenon, including insulin resistance, oxidative stress, and adipokine production. The objective of this study was to assess the association between metabolic risk factors and colorectal neoplasm.

Methods

Study participants visited the National Cancer Center, Korea, for screening (2007–2009). A total of 1,771 diagnosed adenoma patients and 4,667 polyp-free controls were included. The association between risk factors and colorectal neoplasm was evaluated using logistic regression models.

Results

High waist circumference, blood pressure, and serum triglyceride levels were associated with an increased risk of colorectal adenoma. Metabolic syndrome (MS) was associated with an increased risk of adenoma (OR = 1.44, 95 % CI = 1.23–1.70). The association between MS and colorectal adenoma was observed regardless of advanced/low-risk adenoma, and multiplicity. MS affected right colon adenomas (OR = 1.50, 95 % CI = 1.22–1.85), left colon adenomas (OR = 1.36, 95 % CI = 1.05–1.76), and adenomas in multiple anatomical locations (OR = 1.59, 95 % CI = 1.19–2.12), but was not associated with rectum.

Conclusion

Central obesity, triglyceride level, and MS are risk factors for colorectal adenoma including advanced adenoma and multiplicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108

    Article  PubMed  Google Scholar 

  2. Jung KW, Park S, Kong HJ et al (2010) Cancer statistics in Korea: incidence, mortality and survival in 2006–2007. J Korean Med Sci 25:1113–1121

    Article  PubMed  Google Scholar 

  3. Vogelstein B, Fearon ER, Hamilton SR et al (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525–532

    Article  PubMed  CAS  Google Scholar 

  4. Winawer SJ, Zauber AG, Ho MN et al (1993) Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 329:1977–1981

    Article  PubMed  CAS  Google Scholar 

  5. Lieberman DA, Weiss DG, Bond JH, Ahnen DJ, Garewal H, Chejfec G (2000) Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N Engl J Med 343:162–168

    Article  PubMed  CAS  Google Scholar 

  6. Chiu HM, Lin JT, Shun CT et al (2007) Association of metabolic syndrome with proximal and synchronous colorectal neoplasm. Clin Gastroenterol Hepatol 5:221–229

    Article  PubMed  CAS  Google Scholar 

  7. Limburg PJ, Anderson KE, Johnson TW et al (2005) Diabetes mellitus and subsite-specific colorectal cancer risks in the Iowa Women’s Health Study. Cancer Epidemiol Biomarkers Prev 14:133–137

    PubMed  Google Scholar 

  8. Slattery ML, Benson J, Berry TD et al (1997) Dietary sugar and colon cancer. Cancer Epidemiol Biomarkers Prev 6:677–685

    PubMed  CAS  Google Scholar 

  9. Khandwala HM, McCutcheon IE, Flyvbjerg A, Friend KE (2000) The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev 21:215–244

    Article  PubMed  CAS  Google Scholar 

  10. Prisco M, Romano G, Peruzzi F, Valentinis B, Baserga R (1999) Insulin and IGF-I receptors signaling in protection from apoptosis. Horm Metab Res 31:80–89

    Article  PubMed  CAS  Google Scholar 

  11. Ma J, Pollak MN, Giovannucci E et al (1999) Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst 91:620–625

    Article  PubMed  CAS  Google Scholar 

  12. Ahmed RL, Schmitz KH, Anderson KE, Rosamond WD, Folsom AR (2006) The metabolic syndrome and risk of incident colorectal cancer. Cancer 107:28–36

    Article  PubMed  Google Scholar 

  13. Murphy TK, Calle EE, Rodriguez C, Kahn HS, Thun MJ (2000) Body mass index and colon cancer mortality in a large prospective study. Am J Epidemiol 152:847–854

    Article  PubMed  CAS  Google Scholar 

  14. Wang YY, Lin SY, Lai WA, Liu PH, Sheu WH (2005) Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population. J Gastroenterol Hepatol 20:1410–1415

    Article  PubMed  Google Scholar 

  15. Morita T, Tabata S, Mineshita M, Mizoue T, Moore MA, Kono S (2005) The metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self-Defense Forces health study. Asian Pac J Cancer Prev 6:485–489

    PubMed  Google Scholar 

  16. Kim JH, Lim YJ, Kim YH et al (2007) Is metabolic syndrome a risk factor for colorectal adenoma? Cancer Epidemiol Biomarkers Prev 16:1543–1546

    Article  PubMed  CAS  Google Scholar 

  17. Bowers K, Albanes D, Limburg P et al (2006) A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers. Am J Epidemiol 164:652–664

    Article  PubMed  Google Scholar 

  18. Nam SY, Kim BC, Han KS et al (2010) Abdominal visceral adipose tissue predicts risk of colorectal adenoma in both sexes. Clin Gastroenterol Hepatol 8(443–50):e1–e2

    PubMed  Google Scholar 

  19. Pelucchi C, Negri E, Talamini R et al (2010) Metabolic syndrome is associated with colorectal cancer in men. Eur J Cancer 46:1866–1872

    Article  PubMed  Google Scholar 

  20. Shin A, Hong CW, Sohn DK, et al (2011) Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea. Am J Epidemiol 174:552–562

    Google Scholar 

  21. Dixon MF (2002) Gastrointestinal epithelial neoplasia: Vienna revisited. Gut 51:130–131

    Article  PubMed  CAS  Google Scholar 

  22. Hamilton SR, Aaltonen LA (2000) Pathology and genetics of tumours of the digestive system. IARC Press/Oxford University Press, Lyon/Oxford [distributor]

  23. Morois S, Mesrine S, Besemer F, Josset M, Clavel-Chapelon F, Boutron-Ruault MC (2011) Risks of colon and rectal adenomas are differentially associated with anthropometry throughout life: the French E3N prospective cohort. Int J Epidemiol 40:1269–1279

    Google Scholar 

  24. Morois S, Mesrine S, Josset M, Clavel-Chapelon F, Boutron-Ruault MC (2010) Anthropometric factors in adulthood and risk of colorectal adenomas: The French E3N-EPIC prospective cohort. Am J Epidemiol 172:1166–1180

    Article  PubMed  Google Scholar 

  25. Region W (2000) IASO and IOTF: the Asia-Pacific perspective: redefining obesity and its treatment. Health Communications Australia Pty Limit., Sydney

    Google Scholar 

  26. Ramachandran A, Snehalatha C, Satyavani K, Sivasankari S, Vijay V (2003) Metabolic syndrome in urban Asian Indian adults—a population study using modified ATP III criteria. Diabetes Res Clin Pract 60:199–204

    Article  PubMed  CAS  Google Scholar 

  27. Liu CS, Hsu HS, Li CI et al (2010) Central obesity and atherogenic dyslipidemia in metabolic syndrome are associated with increased risk for colorectal adenoma in a Chinese population. BMC Gastroenterol 10:51

    Article  PubMed  CAS  Google Scholar 

  28. Tsilidis KK, Brancati FL, Pollak MN et al (2010) Metabolic syndrome components and colorectal adenoma in the CLUE II cohort. Cancer Causes Control 21:1–10

    Article  PubMed  Google Scholar 

  29. Frezza EE, Wachtel MS, Chiriva-Internati M (2006) Influence of obesity on the risk of developing colon cancer. Gut 55:285–291

    Article  PubMed  CAS  Google Scholar 

  30. Gunter MJ, Hoover DR, Yu H et al (2008) Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women. Cancer Res 68:329–337

    Article  PubMed  CAS  Google Scholar 

  31. Giorgino F, Laviola L, Eriksson JW (2005) Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies. Acta Physiol Scand 183:13–30

    Article  PubMed  CAS  Google Scholar 

  32. Cowey S, Hardy RW (2006) The metabolic syndrome: a high-risk state for cancer? Am J Pathol 169:1505–1522

    Article  PubMed  CAS  Google Scholar 

  33. Trayhurn P, Beattie JH (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 60:329–339

    Article  PubMed  CAS  Google Scholar 

  34. Trayhurn P, Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347–355

    Article  PubMed  CAS  Google Scholar 

  35. Pais R, Silaghi H, Silaghi AC, Rusu ML, Dumitrascu DL (2009) Metabolic syndrome and risk of subsequent colorectal cancer. World J Gastroenterol 15:5141–5148

    Article  PubMed  CAS  Google Scholar 

  36. Park HS, Kim SM, Lee JS et al (2007) Prevalence and trends of metabolic syndrome in Korea: Korean National Health and Nutrition Survey 1998–2001. Diabetes Obes Metab 9:50–58

    Article  PubMed  CAS  Google Scholar 

  37. Choe JW, Chang HS, Yang SK et al (2007) Screening colonoscopy in asymptomatic average-risk Koreans: analysis in relation to age and sex. J Gastroenterol Hepatol 22:1003–1008

    Article  PubMed  Google Scholar 

  38. Chung SJ, Kim YS, Yang SY et al (2010) Prevalence and risk of colorectal adenoma in asymptomatic Koreans aged 40–49 years undergoing screening colonoscopy. J Gastroenterol Hepatol 25:519–525

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported in part by grants NCC-0910160 (H. J. C), NCC-0710360 (C. W. H), and NCC-0910220 (A. S) from the National Cancer Center, Korea. The authors thank Jeong-Hee Lee, MS for her help in manuscript preparation.

Conflicts of interest

None declared.

Author information

Authors and Affiliations

  1. Center for Colorectal Cancer, Research Institute and Hospital of National Cancer Center, Goyang-si, Korea

    Byung Chang Kim, Chang Won Hong, Dae Kyung Sohn, Kyung Su Han, Ji Won Park, Hee Jin Chang, Hyo Seong Choi & Jae Hwan Oh

  2. Center for Cancer Prevention and Detection, Hospital of National Cancer Center, Goyang-si, Korea

    Byung Chang Kim, Chang Won Hong, Dae Kyung Sohn, Kyung Su Han, Kum Hei Ryu, Bum Joon Park & Ji Hyung Nam

  3. Cancer Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Korea

    Aesun Shin & Jeongseon Kim

  4. Center for Colorectal Cancer, Center for Cancer Prevention and Detection, Research Institute and Hospital, National Cancer Center, 809 Madu 1-dong, Ilsandon-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea

    Chang Won Hong

Authors
  1. Byung Chang Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aesun Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chang Won Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dae Kyung Sohn
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kyung Su Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kum Hei Ryu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Bum Joon Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ji Hyung Nam
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ji Won Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Hee Jin Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Hyo Seong Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Jeongseon Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Jae Hwan Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chang Won Hong.

Additional information

Byung Chang Kim and Aesun Shin have contributed equally to this work.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 99 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, B.C., Shin, A., Hong, C.W. et al. Association of colorectal adenoma with components of metabolic syndrome. Cancer Causes Control 23, 727–735 (2012). https://doi.org/10.1007/s10552-012-9942-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10552-012-9942-9

Keywords

Search

Navigation