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Impact of body mass index in Korean patients with renal cell carcinoma

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Abstract

Objective

The aim of the current study was to examine the impact of preoperative body mass index (BMI) in Korean patients with surgically treated renal cell carcinoma (RCC).

Methods

From 1994 to 2008, a total of 1,487 patients underwent nephrectomy for RCC. All patients were classified into three groups according to Asian BMI classification by Asia Cohort Consortium: <18.5, 18.5 to <25, and 25 kg/m2 or greater group, which represents the underweight (n = 42, 2.8%), normal (n = 833, 56.0%), and obesity (n = 612, 41.2%) group, respectively. Survival analyses and predictive factors for cancer-specific survival among the three groups were evaluated. Subgroup survival analysis of organ-confined and advanced disease was performed.

Results

An overall median follow-up was 54.8 months. Mean ± SE estimated cancer-specific survival in all patients at 5 and 10 years was 88.0 ± 1.0% and 81.4 ± 1.4%, respectively. In the multivariate model after adjusting preoperative and postoperative variables, the underweight group had a significantly worse prognosis than the normal group (hazard ratio (HR): 2.17, 95% confidence interval (95% CI): 1.16–4.08, p = 0.016), meanwhile the obesity group was associated with improved survival (HR: 0.66, 95% CI: 0.45–0.96, p = 0.032). In the subgroup analysis of advanced RCC, obesity was associated with better prognosis than the normal group after applying multivariate analysis (p = 0.001).

Conclusions

Preoperative underweight could be a new independent factor to predict unfavorable cancer-specific survival in Korean patients with RCC treated by surgery. Moreover, obesity was verified to be associated with superior cancer-specific survival.

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Conflict of interest

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Authors and Affiliations

  1. Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Korea

    Hyun Hwan Sung, Seong Soo Jeon, Seo Yong Park, Byong Chang Jeong, Seong Il Seo, Hyun Moo Lee & Han-Yong Choi

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  1. Hyun Hwan Sung
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  2. Seong Soo Jeon
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  3. Seo Yong Park
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  4. Byong Chang Jeong
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  5. Seong Il Seo
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  7. Han-Yong Choi
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Correspondence to Seong Soo Jeon.

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Sung, H.H., Jeon, S.S., Park, S.Y. et al. Impact of body mass index in Korean patients with renal cell carcinoma. Cancer Causes Control 23, 505–511 (2012). https://doi.org/10.1007/s10552-012-9910-4

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  • DOI: https://doi.org/10.1007/s10552-012-9910-4

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