Cancer Causes & Control

, Volume 24, Issue 2, pp 391–402

Parental alcohol consumption and risk of childhood acute lymphoblastic leukemia and brain tumors

  • Elizabeth Milne
  • Kathryn R. Greenop
  • Rodney J. Scott
  • Nicholas H. de Klerk
  • Carol Bower
  • Lesley J. Ashton
  • John A. Heath
  • Bruce K. Armstrong
Original Paper

DOI: 10.1007/s10552-012-0125-5

Cite this article as:
Milne, E., Greenop, K.R., Scott, R.J. et al. Cancer Causes Control (2013) 24: 391. doi:10.1007/s10552-012-0125-5

Abstract

Purpose

Childhood acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and brain tumors (CBTs) are the leading cause of cancer death in children. In our Australian case–control studies of these cancers, we investigated whether parental alcohol consumption before or during pregnancy was associated with risk.

Methods

Cases were identified through the ten Australian pediatric oncology centers, and controls were recruited through national random-digit dialling. Detailed information on alcohol consumption, including beverage type, amount, and timing, was collected from 690 case families (388 ALL and 302 CBT) and 1,396 control families. Data were analyzed using unconditional logistic regression.

Results

We found no evidence that maternal alcohol use before or during pregnancy was associated with an increased risk of either cancer; rather, there was evidence of inverse associations, particularly with wine. For both cancers, we observed U-shaped associations with paternal alcohol consumption in the year before the pregnancy, possibly driven by reduced risk at moderate levels of beer and wine intake and increased risk associated with high levels of beer intake. Moderate intake of spirits by fathers was associated with an increased risk of CBT but not ALL. These findings would be strengthened by corroboration in other studies. While the inverse associations with wine may be interesting mechanistically, the public health message remains that maternal alcohol use during pregnancy causes serious disorders in the offspring and should be avoided.

Conclusions

Our findings suggest that men, as well as women, should limit their alcohol intake when planning a pregnancy.

Keywords

Alcohol Leukemia Brain tumors Childhood Epidemiology Neoplasms Pregnancy 

Supplementary material

10552_2012_125_MOESM1_ESM.doc (68 kb)
Supplementary material 1 (DOC 67 kb)
10552_2012_125_MOESM2_ESM.doc (80 kb)
Supplementary material 2 (DOC 79 kb)
10552_2012_125_MOESM3_ESM.doc (58 kb)
Supplementary material 3 (DOC 57 kb)
10552_2012_125_MOESM4_ESM.doc (76 kb)
Supplementary material 4 (DOC 75 kb)
10552_2012_125_MOESM5_ESM.doc (84 kb)
Supplementary material 5 (DOC 84 kb)

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Elizabeth Milne
    • 1
  • Kathryn R. Greenop
    • 1
  • Rodney J. Scott
    • 2
    • 3
  • Nicholas H. de Klerk
    • 1
  • Carol Bower
    • 1
  • Lesley J. Ashton
    • 4
  • John A. Heath
    • 5
    • 6
  • Bruce K. Armstrong
    • 7
  1. 1.Telethon Institute for Child Health Research, Centre for Child Health ResearchUniversity of Western AustraliaWest PerthAustralia
  2. 2.Faculty of Health, Hunter Medical Research Institute, School of Biomedical SciencesUniversity of NewcastleNewcastleAustralia
  3. 3.Hunter Area Pathology ServiceHNEHealthNewcastleAustralia
  4. 4.Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research CentreUniversity of New South WalesSydneyAustralia
  5. 5.Children’s Cancer CentreRoyal Children’s HospitalMelbourneAustralia
  6. 6.Department of PaediatricsUniversity of MelbourneMelbourneAustralia
  7. 7.Sydney School of Public HealthUniversity of SydneySydneyAustralia

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