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Comorbidities and endometrial cancer survival in Hispanics and non-Hispanic whites

Cancer Causes & Control volume 24, pages 61–69 (2013)Cite this article

Abstract

Purpose

We investigated comorbidities and endometrial cancer survival by ethnicity because Hispanic whites (HWs) have worse survival than non-Hispanic whites (NHWs).

Methods

An endometrial cancer cohort (1992–2004) established with the Surveillance, Epidemiology and End Results-Medicare-linked database (n = 3,286) was followed through 2007. Endometrial cancer-specific and other cause mortality were evaluated with multivariate hazard ratios (mHRs).

Results

HWs were more likely than NHWs to have regional/distant disease (31.7 vs. 24.8 %), diabetes (31.7 vs. 11.0 %), and hypertension (49.4 vs. 37.6 %). HWs had poorer endometrial cancer-specific survival than NHWs (age-adjusted HR = 1.28; 95% CI 1.01–1.61), but not after adjustment for tumor characteristics and treatment (mHR = 1.02; 95% CI 0.81–1.29). In contrast, even after adjustment for cancer-related factors, other cause mortality in HWs was elevated (mHR = 1.27; 95% CI 1.01–1.59), but not after further adjustment for comorbid conditions (mHR = 1.07; 95% CI 0.85–1.35).

Conclusions

Comorbidities, particularly diabetes, were more common in HWs than in NHWs and impacted other cause mortality. Improving diabetes management may be an effective means of improving other cause mortality. This may be particularly true for HWs, given their particularly high prevalence of diabetes.

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Acknowledgments

This research was supported by grant 1R03CA143610–01 and contract HHSN261201000033C from the US National Cancer Institute, US National Institutes of Health. Additional support was provided by the University of New Mexico Cancer Research and Treatment Center, a recipient of NCI Cancer Support Grant 2 P30 CA118100-07.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Affiliations

  1. Division of Epidemiology and Biostatistics, Department of Internal Medicine and UNM Cancer Research and Treatment Center, MSC 10 5550, 1 University of New Mexico, Albuquerque, NM, 87131-0001, USA

    Linda S. Cook & Charles L. Wiggins

  2. New Mexico Tumor Registry, University of New Mexico, Albuquerque, NM, USA

    Harold E. Nelson

  3. Department of Preventive Medicine and USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA

    Myles Cockburn

  4. Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Sara H. Olson

  5. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM, USA

    Carolyn Y. Muller

Authors
  1. Linda S. Cook
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  2. Harold E. Nelson
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  3. Myles Cockburn
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  4. Sara H. Olson
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  5. Carolyn Y. Muller
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  6. Charles L. Wiggins
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Correspondence to Linda S. Cook.

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Cook, L.S., Nelson, H.E., Cockburn, M. et al. Comorbidities and endometrial cancer survival in Hispanics and non-Hispanic whites. Cancer Causes Control 24, 61–69 (2013). https://doi.org/10.1007/s10552-012-0090-z

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  • DOI: https://doi.org/10.1007/s10552-012-0090-z

Keywords

  • Endometrial neoplasms
  • Comorbidities
  • Survival
  • SEER
  • Medicare