Cancer Causes & Control

, Volume 23, Issue 11, pp 1775–1783 | Cite as

Intake of omega-3 and omega-6 fatty acids and risk of ovarian cancer

  • T. I. Ibiebele
  • C. M. Nagle
  • C. J. Bain
  • P. M. Webb
Original paper

Abstract

Objectives

Limited experimental evidence suggests that omega-3 polyunsaturated (n-3) fatty acids inhibit the proliferation of ovarian cancer cells in vitro, whereas omega-6 polyunsaturated (n-6) fatty acids have been shown to promote carcinogenesis, but epidemiological studies to date have been inconclusive. Our aim was to evaluate the role of polyunsaturated fatty acids in ovarian carcinogenesis.

Methods

Participants in the Australian Ovarian Cancer Study (1,366 cases and 1,414 population controls) self-completed risk factor and food frequency questionnaires. Logistic regression models were used to calculate adjusted odds ratio (OR) and 95 % confidence intervals (CI).

Results

We found no association between intake of total n-3 fatty acids from foods, or the individual n-3 fatty acids—alpha-linolenic, eicosapentaenoic, docosapentaenoic, docosahexaenoic acids—and ovarian cancer risk. High intake of total n-6 fatty acids was inversely associated with risk (OR for highest vs. lowest category 0.78, 95 % CI 0.60–1.00, p-trend0.04); however, the association was restricted to n-6 fatty acids from avocado, vegetables, and nuts. Neither higher intake of the individual n-6 fatty acids nor the ratio of n-3 to n-6 fatty acids was associated with ovarian cancer risk. We found no evidence that risk varied by supplement use.

Conclusions

Our data provide no evidence of a protective role for n-3 fatty acids in ovarian carcinogenesis. The benefit, if any, of higher intake of n-6 fatty acids is due to general properties of the food sources, rather than due to the n-6 fatty acids per se.

Keywords

Polyunsaturated fatty acids Ovarian cancer Risk Omega-3 polyunsaturated fatty acids Omega-6 polyunsaturated fatty acids 

Supplementary material

10552_2012_53_MOESM1_ESM.docx (23 kb)
Supplementary material 1 (DOCX 23 kb)

References

  1. 1.
    Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Waldron W et al. (2011) SEER Cancer Statistics Review, 1975–2008. http://seer.cancer.gov/csr/1975_2008/. Accessed on 22 March 2012
  2. 2.
    Adami H-O, Hunter D (2008) Textbook of cancer epidemiology. University Press, OxfordCrossRefGoogle Scholar
  3. 3.
    Huncharek M, Kupelnick B (2001) Dietary fat intake and risk of epithelial ovarian cancer: a meta-analysis of 6,689 subjects from 8 observational studies. Nutr Cancer 40(2):87–91. doi:10.1207/S15327914NC402_2 PubMedCrossRefGoogle Scholar
  4. 4.
    Genkinger JM, Hunter DJ, Spiegelman D, Anderson KE, Beeson WL, Buring JE et al (2006) A pooled analysis of 12 cohort studies of dietary fat, cholesterol and egg intake and ovarian cancer. Cancer Causes Control 17(3):273–285. doi:10.1007/s10552-005-0455-7 PubMedCrossRefGoogle Scholar
  5. 5.
    Rose DP, Connolly JM, Coleman M (1996) Effect of omega-3 fatty acids on the progression of metastases after the surgical excision of human breast cancer cell solid tumors growing in nude mice. Clin Cancer Res 2(10):1751–1756PubMedGoogle Scholar
  6. 6.
    Rose DP, Connolly JM (1993) Effects of dietary omega-3 fatty acids on human breast cancer growth and metastases in nude mice. J Natl Cancer Inst 85(21):1743–1747PubMedCrossRefGoogle Scholar
  7. 7.
    Rose DP, Connolly JM (1999) Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther 83(3):217–244PubMedCrossRefGoogle Scholar
  8. 8.
    Cockbain AJ, Toogood GJ, Hull MA (2012) Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer. Gut 61(1):135–149. doi:10.1136/gut.2010.233718 Google Scholar
  9. 9.
    Sharma A, Belna J, Espat J, Rodriguez G, Cannon VT, Hurteau JA (2009) Effects of omega-3 fatty acids on components of the transforming growth factor beta-1 pathway: implication for dietary modification and prevention in ovarian cancer. Am J Obstet Gynecol 200(5):516 e511–516 e516. doi:10.1016/j.ajog.2008.12.023
  10. 10.
    Sharma A, Belna J, Logan J, Espat J, Hurteau JA (2005) The effects of Omega-3 fatty acids on growth regulation of epithelial ovarian cancer cell lines. Gynecol Oncol 99(1):58–64. doi:10.1016/j.ygyno.2005.05.024 Google Scholar
  11. 11.
    Ansenberger K, Richards C, Zhuge Y, Barua A, Bahr JM, Luborsky JL, Hales DB (2010) Decreased severity of ovarian cancer and increased survival in hens fed a flaxseed-enriched diet for 1 year. Gynecol Oncol 117(2):341–347. doi:10.1016/j.ygyno.2010.01.021 Google Scholar
  12. 12.
    Fay MP, Freedman LS, Clifford CK, Midthune DN (1997) Effect of different types and amounts of fat on the development of mammary tumors in rodents: a review. Cancer Res 57(18):3979–3988PubMedGoogle Scholar
  13. 13.
    Rose DP (1997) Effects of dietary fatty acids on breast and prostate cancers: evidence from in vitro experiments and animal studies. Am J Clin Nutr 66(6 suppl):1513S–1522SPubMedGoogle Scholar
  14. 14.
    MacLean CH, Newberry SJ, Mojica WA, Khanna P, Issa AM, Suttorp MJ, Lim YW, Traina SB, Hilton L, Garland R, Morton SC (2006) Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA 295(4):403–415. doi:10.1001/jama.295.4.403 Google Scholar
  15. 15.
    Hooper, L, Thompson RL, Harrison RA, Summerbell CD, Ness AR, Moore HJ, Worthington HV, Durrington PN, Higgins JP, Capps NE, Riemersma RA, Ebrahim SB, Davey Smith G (2006) Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 332(7544):752–760. doi:10.1136/bmj.38755.366331.2F Google Scholar
  16. 16.
    Blank MM, Wentzensen N, Murphy MA, Hollenbeck A, Park Y (2012) Dietary fat intake and risk of ovarian cancer in the NIH-AARP diet and health study. Br J Cancer 106(3):596–602. doi:10.1038/bjc.2011.572 PubMedCrossRefGoogle Scholar
  17. 17.
    Tavani A, Pelucchi C, Parpinel M, Negri E, Franceschi S, Levi F et al (2003) n-3 polyunsaturated fatty acid intake and cancer risk in Italy and Switzerland. Int J Cancer 105(1):113–116. doi:10.1002/ijc.11018 PubMedCrossRefGoogle Scholar
  18. 18.
    Bidoli E, La Vecchia C, Montella M, Maso LD, Conti E, Negri E et al (2002) Nutrient intake and ovarian cancer: an Italian case-control study. Cancer Causes Control 13(3):255–261PubMedCrossRefGoogle Scholar
  19. 19.
    Bertone ER, Rosner BA, Hunter DJ, Stampfer MJ, Speizer FE, Colditz GA et al (2002) Dietary fat intake and ovarian cancer in a cohort of US women. Am J Epidemiol 156(1):22–31PubMedCrossRefGoogle Scholar
  20. 20.
    Merritt MA, Green AC, Nagle CM, Webb PM (2008) Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer. Int J Cancer 122(1):170–176. doi:10.1002/ijc.23017 PubMedCrossRefGoogle Scholar
  21. 21.
    Willett W, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J et al (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 122:51–65PubMedGoogle Scholar
  22. 22.
    McNaughton SA, Mishra GD, Brunner EJ (2007) Validation of a FFQ to estimate the intake of PUFA using plasma phospholipid fatty acids and weighed foods records. Br J Nutr 97(3):561–568. doi:10.1017/S0007114509243030 Google Scholar
  23. 23.
    Ibiebele TI, Parekh S, Mallitt KA, Hughes MC, O’Rourke PK, Webb PM (2009) Reproducibility of food and nutrient intake estimates using a semi-quantitative FFQ in Australian adults. Public Health Nutr 12(12):2359–2365. doi:10.1017/S1368980009005023 Google Scholar
  24. 24.
    Mann N, Sinclair A, Percival P, Lewis J, Meyer B (2003) Development of a database of fatty acids in Australian foods. Nutr Diet 60(1):42–45Google Scholar
  25. 25.
    Ashton BA, Ambrosini GL, Marks GC, Harvey PW, Bain C (1997) Development of a dietary supplement database. Aust N Z J Public Health 21(7):699–702PubMedCrossRefGoogle Scholar
  26. 26.
    World Health Organisation (2000) Obesity: preventing and managing the global epidemic-report of a WHO Consultation on Obesity. WHO Technical Report Series (no. 894). Geneva, SwitzerlandGoogle Scholar
  27. 27.
    Marks GC, Hughes MC, van der Pols JC (2006) Relative validity of food intake estimates using a food frequency questionnaire is associated with sex, age, and other personal characteristics. J Nutr 136(2):459–465PubMedGoogle Scholar
  28. 28.
    Signori C, El-Bayoumy K, Russo J, Thompson HJ, Richie JP, Hartman TJ, Manni A (2011) Chemoprevention of breast cancer by fish oil in preclinical models: trials and tribulations. Cancer Res 71(19):6091–6096. doi:10.1158/0008-5472.CAN-11-0977 Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • T. I. Ibiebele
    • 1
  • C. M. Nagle
    • 1
  • C. J. Bain
    • 1
    • 2
  • P. M. Webb
    • 1
  1. 1.Genetics and Population Health DivisionQueensland Institute of Medical ResearchHerston, BrisbaneAustralia
  2. 2.National Centre for Epidemiology and Population HealthThe Australian National UniversityCanberraAustralia

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