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Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case–control study

Abstract

Background

Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC).

Methods

A case–control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case.

Results

Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58–1.62) or GCT (OR 1.13, 95% CI 0.51–2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85–1.43) or GCT (OR 0.93, 95% CI 0.68–1.28).

Conclusions

Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.

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Acknowledgments

This research was supported by the National Cancer Institute at the National Institutes of Health. The funding source had no role in the study design, interpretation of data, and publication of results. This study was conducted while Adetunji T Toriola was at the National Institute for Health and Welfare, Finland. He was supported by a European Association for Cancer Research (EACR) Travel Fellowship Award to visit the Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg. The authors are indebted to Yelena Afanasyeva, Pirjo Kontiokari, Annika Uimonen, and Sara Kuusiniemi for their excellent technical assistance in the conduct of the study.

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None declared.

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Toriola, A.T., Surcel, HM., Lundin, E. et al. Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer: a nested case–control study. Cancer Causes Control 22, 1607 (2011). https://doi.org/10.1007/s10552-011-9828-2

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  • DOI: https://doi.org/10.1007/s10552-011-9828-2

Keywords

  • Insulin-like growth factor (IGF-I)
  • C-reactive protein (CRP)
  • Pregnancy
  • Non-epithelial ovarian cancer
  • Nested case–control study