Drinking water fluoridation and osteosarcoma incidence on the island of Ireland
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The incidence of osteosarcoma in Northern Ireland was compared with that in the Republic of Ireland to establish if differences in incidence between the two regions could be related to their different drinking water fluoridation policies. Data from the Northern Ireland Cancer Registry (NICR) and the National Cancer Registry of Ireland (NCRI) on osteosarcoma incidence in the respective populations were used to estimate the age-standardised and age-specific incidence rates in areas with and without drinking water fluoridation. One hundred and eighty-three osteosarcoma cases were recorded on the island of Ireland between 1994 and 2006. No significant differences were observed between fluoridated and non-fluoridated areas in either age-specific or age-standardised incidence rates of osteosarcoma. The results of this study do not support the hypothesis that osteosarcoma incidence in the island of Ireland is significantly related to public water fluoridation. However, this conclusion must be qualified, in view of the relative rarity of the cancer and the correspondingly wide confidence intervals of the relative risk estimates.
KeywordsOsteosarcoma Fluoridation Drinking water Ireland
We would like to thank the staff at the National Cancer Registry Ireland, Cork and the N. Ireland Cancer Registry, Belfast and for their work in collecting and processing of the data used in this study. The N. Ireland Cancer Registry is funded by the Public Health Agency for Northern Ireland.
- 1.Bielack SS, Bernstein ML (2005) Osteosarcoma. Cancer in children, clinical management, 5th edn. Oxford University Press, Oxford, pp 280–300Google Scholar
- 4.Curado MP, Edwards B et al. (2007) Cancer incidence in five continents vol IX. IARC Scientific Publications No 160Google Scholar
- 16.National Academy of Sciences (2006) Fluoride in drinking water: a scientific review of EPAs standardsGoogle Scholar
- 17.National Health and Medical Research Council (2007) A systematic review of the efficacy and safety of fluoridation. Australian Government, http://www.nhmrc.gov.au
- 18.WHO Expert Committee on Oral Health Status and Fluoride Use (1994) Fluorides and oral health. Geneva: World Health Organisation http://whqlibdoc.who.int/trs/WHO_TRS_846.pdf
- 20.Health (Fluoridation of Water Supplies) Act 1960. House of the oireachtas, DublinGoogle Scholar
- 21.Forum on Fluoridation (2002) Dublin: stationery office www.fluoridationforum.ie
- 22.Owens M, O’Herlihy B (2009) Osteosarcoma in republic of Ireland and Northern Ireland. Irish expert body on fluorides and health. www.fluoridesandhealth.ie/documents/
- 23.Donnelly DW, Gavin AT, Comber H (2009) Cancer in Ireland 1994–2004: a comprehensive report. Northern Ireland Cancer Registry/National Cancer Registry, IrelandGoogle Scholar
- 24.McLoughlin J, Clarkson J, Connolly F, Hargaden J (2005) An evaluation of the delivery and monitoring of water fluoridation in Ireland. A report conducted by the Department of Public and Child Dental Health, Dublin Dental School & Hospital Dublin: Department of Health and Children. http://www.dohc.ie/other_health_issues/dental_research/evaluation.pdf?direct=1
- 25.WHO (1984) Fluorine and fluorides. World Health Organization, Geneva (Environmental Health Criteria 36) http://www.inchem.org/documents/ehc/ehc/ehc36.htm