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ASIP genetic variants and the number of non-melanoma skin cancers

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Abstract

Patients with primary non-melanoma skin cancers (NMSCs) tend to develop these cancers at multiple independent sites. We examined the genetic factors in the development of multiple NMSCs among Caucasian women with 28 years of follow-up. We initially evaluated 19 SNPs in nine pigmentation genes with the number of NMSCs in 492 cases and 619 controls without a history of NMSC. We found nominal significant associations between two ASIP gene–related SNPs, rs1885120 and rs910873, and an ASIP haplotype (AH) (rs4911414 allele T and rs1015362 allele G) and an increased number of NMSCs, with p-values of 0.008, 0.01, and 0.01, respectively. We further evaluated these two SNPs and AH haplotype in three data sets. In a joint analysis with 1,507 cases and 4,335 controls, AH haplotype was independently associated with the number of NMSCs with odds ratio (OR) (95% confidence interval (CI)) of 1.45(1.25–1.68) (p-value = 6.2E–07). The AH haplotype was associated with an increased risk of developing one NMSC (OR 1.32; 95% CI, 1.07–1.63). The OR increased to 1.45(1.18–1.78) for those with 2–4 NMSCs and 1.84(1.34–2.53) for those with at least five. The findings suggest that ASIP locus is associated with the number of NMSCs.

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Acknowledgments

We thank Dr. David J. Hunter for the open access to the breast cancer genome-wide SNP scan data set (part of the Cancer Genetic Markers of Susceptibility project). We thank Dr. Hardeep Ranu and Ms. Pati Soule of the Dana Farber/Harvard Cancer Center High-Throughput Polymorphism Detection Core for their laboratory assistance, and Ms. Constance Chen for genotyping imputation. We are also indebted to the participants in the Nurses’ Health Study for their dedication and commitment. (Grant Support: NIH CA122838 and CA128080.)

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The authors state no conflict of interest.

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Authors and Affiliations

  1. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

    Wen Lin, Peter Kraft, Frank B. Hu & Jiali Han

  2. Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA

    Abrar A. Qureshi, Hongmei Nan, Qun Guo, Frank B. Hu & Jiali Han

  3. Clinical Research Program, Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Abrar A. Qureshi & Jiali Han

  4. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA

    Frank B. Hu & Majken K. Jensen

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  1. Wen Lin
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  2. Abrar A. Qureshi
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Correspondence to Jiali Han.

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Wen Lin and Abrar A. Qureshi contribute equally.

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Lin, W., Qureshi, A.A., Kraft, P. et al. ASIP genetic variants and the number of non-melanoma skin cancers. Cancer Causes Control 22, 495–501 (2011). https://doi.org/10.1007/s10552-010-9724-1

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  • DOI: https://doi.org/10.1007/s10552-010-9724-1

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