Skip to main content

Advertisement

SpringerLink
Log in

Dietary acrylamide intake and the risk of cancer among Finnish male smokers

  • Original paper
  • Published:
Cancer Causes & Control Aims and scope Submit manuscript

Abstract

Objective

To assess the association between dietary acrylamide intake and the risk of cancer among male smokers.

Methods

The study consisted of 27,111 male smokers, aged 50–69 years, without history of cancer. They were participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in Finland. The men completed a validated dietary questionnaire and a questionnaire on general background characteristics (including smoking habits) at baseline. Incident cases of cancer were identified through the national Finnish Cancer Registry.

Results

During an average 10.2 year follow-up, 1,703 lung cancers, 799 prostate cancers, 365 urothelial cancers, 316 colorectal cancers, 224 stomach cancers, 192 pancreatic cancers, 184 renal cell cancers, and 175 lymphomas were diagnosed. Dietary acrylamide intake was positively associated with the risk of lung cancer; relative risk (RR) in the highest versus the lowest quintile in the multivariable-adjusted model was 1.18 ((95% confidence interval (CI) 1.01–1.38, p for trend 0.11). Other cancers were not associated with acrylamide intake.

Conclusions

High acrylamide intake is associated with increased risk of lung cancer but not with other cancers in male smokers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Diekmann J, Wittig A, Stabbert R (2008) Gas chromatographic-mass spectrometric analysis of acrylamide and acetamide in cigarette mainstream smoke after on-column injection. J Chromatograph Sci 46:659–663

    CAS  Google Scholar 

  2. Eerola S, Hollebekkers K, Hallikainen A, Peltonen K (2007) Acrylamide levels in Finnish foodstuffs analysed with liquid chromatography tandem mass spectrometry. Mol Nutr Food Res 51:239–247

    Article  CAS  PubMed  Google Scholar 

  3. Erdreich L, Friedman MA (2004) Epidemiologic evidence for assessing the carcinogenicity of acrylamide. Regul Toxicol Pharmacol 39:150–157

    Article  CAS  PubMed  Google Scholar 

  4. Wirfält E, Paulson B, Törnqvist M, Axmon A, Hagmar L (2007) Associations between estimated acrylamide intake, and haemoglobin AA adducts in a sample from the Malmö Diet and cancer cohort. Eur J Clin Nutr 62:314–323

    Article  PubMed  Google Scholar 

  5. Besaratinia A, Pfeifer GP (2007) A review of mechanisms of acrylamide carcinogenicity. Carcinogenesis 28:519–528

    Article  CAS  PubMed  Google Scholar 

  6. International Agency for Research on Cancer (1994) IARC monographs of the evaluation of carcinogenic risks to humans, vol 60. Some industrial chemicals. IARC, Lyon

    Google Scholar 

  7. Ghanayem BI, McDaniel LP, Churchwell MI, Twaddle NC, Snyder R, Fennell TR, Doerge DR (2005) Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and haemoglobin adducts. Toxicol Sci 88:311–318

    Article  CAS  PubMed  Google Scholar 

  8. Mucci LA, Adami HO, Wolk A (2006) Prospective study of dietary acrylamide and risk of colorectal cancer among women. Int J Cancer 118:169–173

    Article  CAS  PubMed  Google Scholar 

  9. Pelucchi C, Galeone C, Levi F, Negri E, Franceschi S, Talamini R, Bosetti C, Giacosa A, La Vecchia C (2006) Dietary acrylamide and human cancer. Int J Cancer 2006 118:467–471

    Article  CAS  Google Scholar 

  10. Hogervorst JG, Schouten LJ, Konigs EJ, Goldbohm RA, van der Brandt PA (2007) A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer. Cancer Epidemiol Biomarkers Prev 16:2304–2313

    Article  CAS  PubMed  Google Scholar 

  11. Olesen PT, Olsen A, Frandsen H, Frederiksen K, Overvad K, Tjønneland A (2008) Acrylamide exposure and incidence of breast cancer among postmenopausal women in Danish Diet, cancer and health study. Int J Cancer 22:2094–2100

    Article  Google Scholar 

  12. Hogervorst JG, Schouten LJ, Konigs EJ, Goldbohm RA, van der Brandt PA (2008) Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer. Am J Clin Nutr 87:1428–1438

    CAS  PubMed  Google Scholar 

  13. Hogervorst JG, Schouten LJ, Konigs EJ, Goldbohm RA, van den Brandt PA (2008) Dietary acrylamide intake is not associated with gastrointestinal cancer risk. J Nutr 138:2229–2236

    Article  CAS  PubMed  Google Scholar 

  14. Hogervorst JG, Schouten LJ, Konigs EJ, Goldbohm RA, van der Brandt PA (2009) Lung cancer risk in relation to dietary acrylamide intake. J Natl Cancer Inst 101:651–662

    Article  CAS  PubMed  Google Scholar 

  15. Larsson SC, Akeson A, Wolk A (2009) Long-term dietary acrylamide intake and risk of epithelial ovarian cancer in a prospective cohort of Swedish women. Cancer Epidemiol Biomarkers Prev 18:994–997

    Article  CAS  PubMed  Google Scholar 

  16. Larsson SC, Akesson A, Wolk A (2009) Long-term dietary acrylamide intake and breast cancer risk in a prospective cohort of Swedish women. Am J Epidemiol 169:376–381

    Article  PubMed  Google Scholar 

  17. Larsson SC, Håkansson N, Akesson A, Wolk A (2009) Long-term dietary acrylamide intake and risk of endometrial cancer in a prospective cohort of Swedish women. Int J Cancer 124:1196–1199

    Article  CAS  PubMed  Google Scholar 

  18. Wilson KM, Bälter K, Adami HO, Grönberg H, Vikström AC, Paulson B, Törnqvist M, Mucci LA (2009) Acrylamide exposure measured by food frequency questionnaire and hemoglobin adduct levels and prostate cancer risk in the Cancer of the Prostate in Sweden Study. Int J Cancer 124:2384–2390

    Article  CAS  PubMed  Google Scholar 

  19. Wilson KM, Mucci LA, Cho E, Hunter DJ, Chen WY, Willett WC (2009) Dietary acrylamide intake and risk of premenopausal breast cancer. Am J Epidemiol 169:954–961

    Article  PubMed  Google Scholar 

  20. Hogervorst JG, Schouten LJ, Konigs EJ, Goldbohm RA, van der Brandt PA (2009) Dietary acrylamide intake and brain cancer risk. Cancer Epidemiol Biomarkers Prev 18:1663–1666

    Article  CAS  PubMed  Google Scholar 

  21. Pedersen GS, Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, van der Brandt PA (2010) Dietary acrylamide intake and estrogen and progesterone receptor-defined postmenopausal breast cancer risk. Breast Cancer Res Treat 122:199–210

    Article  CAS  PubMed  Google Scholar 

  22. Wilson KM, Mucci LA, Rosner BA, Willett WC A prospective study of dietary acrylamide intake and the risk of breast, endometrial, and ovarian cancers. Cancer Epidemiol Biomarkers Prev. 2010 Aug 6 (Epub ahead of print)

  23. Mucci LA, Lindblad P, Steineck G, Adami HO (2004) Dietary acrylamide and risk of renal cell cancer. Int J Cancer 109:774–776

    Article  CAS  PubMed  Google Scholar 

  24. Mucci LA, Dickman PW, Steineck G, Adami HO, Augustsson K (2003) Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. Br J Cancer 88:84–89

    Article  CAS  PubMed  Google Scholar 

  25. Larsson SC, Akesson A, Wolk A (2009) Dietary acrylamide intake and prostate cancer risk in a prospective cohort of Swedish men. Cancer Epidemiol Biomarkers Prev 18:1939–1941

    Article  CAS  PubMed  Google Scholar 

  26. The ATBC Cancer Prevention Study Group (1994) The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. Ann Epidemiol 4:1–10

    Article  Google Scholar 

  27. Pietinen P, Hartman AM, Haapa E, Räsänen L, Haapakoski J, Palmgren J, Albanes D, Virtamo J, Huttunen JK (1988) Reproducibility and validity of dietary assessment instruments. I. A self-administered food use questionnaire with a portion size picture booklet. Am J Epidemiol 128:655–666

    CAS  PubMed  Google Scholar 

  28. Svensson K, Abrahamsson L, Becker W, Glynn A, Hellenäs K-E, Lind Y, Rosén J (2003) Dietary intake of acrylamide in Sweden. Food Chem Toxicol 41:1581–1586

    Article  CAS  PubMed  Google Scholar 

  29. Konings EJM, Baars AJ, van Klaveren JD, Spanjer MC, Rensen PM, Hiemstra M, van Kooij JA, Peters PWJ (2003) Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks. Food Chem Toxicol 41:1569–1579

    Article  CAS  PubMed  Google Scholar 

  30. Korhonen P, Malila N, Pukkala E, Teppo L, Albanes D, Virtamo J (2002) The Finnish Cancer Registry as follow-up source of a large trial cohort–accuracy and delay. Acta Oncol 41:381–388

    Article  PubMed  Google Scholar 

  31. Willett W, Stampfer MJ (1986) Total energy intake: implications for epidemiologic analysis. Am J Epidemiol 124:17–27

    CAS  PubMed  Google Scholar 

  32. Parzefall W (2008) Minireview on the toxicity of dietary acrylamide. Food Chem Toxicol 46:1360–1364

    Article  CAS  PubMed  Google Scholar 

  33. European Food Safety Authority (2009) Results on the monitoring of acrylamide levels in food: a report of the data collection and exposure unit in response to a request from the European commission. EFSA Scientific Rep 285:1–26

    Google Scholar 

  34. Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics–chemistry, bioavailability and effects on health. Nat Prod Rep 26:1001–1043

    Article  CAS  PubMed  Google Scholar 

  35. Jeong HJ, Lee JR, Jeong JB, Park JH, Cheong YK, de Lumen BO (2009) The cancer preventive seed peptide lunasin from rye is bioavailable and bioactive. Nutr Cancer 61:680–686

    Article  CAS  PubMed  Google Scholar 

  36. Wenzl T, Lachenmeier DW, Gökmen V (2007) Analysis of heat-induced contaminants (acrylamide, choloropropanols and furan) in carbohydrate-rich foods. Anal Bioanal Chem 389:119–137

    Article  CAS  PubMed  Google Scholar 

  37. Hirvonen T, Virtamo J, Korhonen P, Albanes D, Pietinen P (2001) Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes Control 12:789–796

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Finnish Food Safety Authority, Risk Assessment Unit, Mustialankatu 3, FI-00790, Helsinki, Finland

    T. Hirvonen

  2. National Institute for Health and Welfare (THL), Department of Chronic Disease Prevention, P.O. Box 30, FI-00271, Helsinki, Finland

    J. Kontto, P. Pietinen & J. Virtamo

  3. Finnish Food Safety Authority, Research Department, Unit of Chemistry and Toxicology, Mustialankatu 3, FI-00790, Helsinki, Finland

    M. Jestoi & K. Peltonen

  4. National Institute for Health and Welfare (THL), Department of Lifestyle and Participation, P.O.Box 30, FI-00271, Helsinki, Finland

    L. Valsta, S. M. Virtanen, H. Sinkko & C. Kronberg-Kippilä

  5. National Cancer Institute, Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, 6120 Executive Blvd, Bethesda, MD, 20892-7242, USA

    D. Albanes

Authors
  1. T. Hirvonen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Kontto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Jestoi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Valsta
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Peltonen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. Pietinen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S. M. Virtanen
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. H. Sinkko
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. C. Kronberg-Kippilä
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. D. Albanes
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. J. Virtamo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. Hirvonen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hirvonen, T., Kontto, J., Jestoi, M. et al. Dietary acrylamide intake and the risk of cancer among Finnish male smokers. Cancer Causes Control 21, 2223–2229 (2010). https://doi.org/10.1007/s10552-010-9642-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10552-010-9642-2

Keywords

Search

Navigation