We evaluated the role of tea and coffee and substances added (sugar/honey, creamers, and milk) on endometrial cancer risk in a population-based case–control study in six counties in New Jersey, including 417 cases and 395 controls. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional logistic regression. There was a moderate inverse association with coffee consumption, with an adjusted OR of 0.65 (95% CI: 0.36–1.17) for women who reported more than two cups/day of coffee compared to none. Tea consumption appeared to increase risk (OR: 1.93; 95% CI: 1.08–3.45), but after including the variables sugar/honey and cream/milk added to tea in the model, the risk estimate was attenuated and no longer statistically significant (OR: 1.77; 95% CI: 0.96–3.28 for those consuming more than one cup/day of tea compared to nonusers). There was a suggestion of a decreased risk associated with green tea, but the confidence interval included one (adjusted OR for one or more cups/week vs. none: 0.75; 95% CI: 0.48–1.18). We found an association with adding sugar/honey to tea, with those adding two or more teaspoons/cup having an OR of 2.66 (95% CI: 1.42–4.98; p for trend <0.01) after adjusting for relevant confounders. For sugar/honey added to coffee the corresponding OR was 1.43 (95% CI: 0.81–2.55). Our results indicate that sugars and milk/cream added to coffee and tea should be considered in future studies evaluating coffee and tea and endometrial cancer risk.
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DeVivo I, Persson I, Adami H-O (2008) Endometrial cancer. In: Adami H-O, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology, 2nd edn. Oxford University Press, New York, pp 468–493
Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough ML (2007) The association between food, nutrition, and physical activity and the risk of endometrial cancer and underlying mechanisms. In: Second Report on Food, Nutrition, Physical Activity and the Prevention of Cancer: World Cancer Research Fund International/American Institute for Cancer Research
Yang CS, Wang X, Lu G, Picinich SC (2009) Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9:429–439
Scalbert A, Manach C, Morand C, Remesy C, Jimenez L (2005) Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45:287–306
Greenberg JA, Axen KV, Schnoll R, Boozer CN (2005) Coffee, tea and diabetes: the role of weight loss and caffeine. Int J Obes 29:1121–1129
Greenberg JA, Boozer CN, Geliebter A (2006) Coffee, diabetes, and weight control. Am J Clin Nutr 84:682–693
Bravi F, Scotti L, Bosetti C et al (2009) Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies. Am J Obstet Gynecol 200:130–135
Astill C, Birch MR, Dacombe C, Humphrey PG, Martin PT (2001) Factors affecting the caffeine and polyphenol contents of black and green tea infusions. J Agric Food Chem 49:5340–5347
Olson SH, Orlow I, Bayuga S et al (2008) Variants in hormone biosynthesis genes and risk of endometrial cancer. Cancer Causes Control 19:955–963
Bandera EV, Williams MG, Sima C et al (2009) Phytoestrogen consumption and endometrial cancer risk: a population-based case–control study in New Jersey. Cancer Causes Control 20:1117–1127
Caan B, Sternfeld B, Gunderson E, Coates A, Quesenberry C, Slattery ML (2005) Life After Cancer Epidemiology (LACE) Study: a cohort of early stage breast cancer survivors (United States). Cancer Causes Control 16:545–556
Horn-Ross PL, Barnes S, Lee M et al (2000) Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States). Cancer Causes Control 11:289–298
Shimazu T, Inoue M, Sasazuki S et al (2008) Coffee consumption and risk of endometrial cancer: a prospective study in Japan. Int J Cancer 123:2406–2410
Friberg E, Orsini N, Mantzoros CS, Wolk A (2009) Coffee drinking and risk of endometrial cancer—a population-based cohort study. Int J Cancer 125:2413–2417
Jain MG, Howe GR, Rohan TE (2000) Nutritional factors and endometrial cancer in Ontario, Canada. Cancer Control 7:288–296
Terry P, Vainio H, Wolk A, Weiderpass E (2002) Dietary factors in relation to endometrial cancer: a nationwide case–control study in Sweden. Nutr Cancer 42:25–32
Koizumi T, Nakaya N, Okamura C et al (2008) Case–control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma. Eur J Cancer Prev 17:358–363
Petridou E, Kedikoglou S, Koukoulomatis P, Dessypris N, Trichopoulos D (2002) Diet in relation to endometrial cancer risk: a case–control study in Greece. Nutr Cancer 44:16–22
Hirose K, Niwa Y, Wakai K, Matsuo K, Nakanishi T, Tajima K (2007) Coffee consumption and the risk of endometrial cancer: evidence from a case–control study of female hormone-related cancers in Japan. Cancer Sci 98:411–415
Bravi F, Scotti L, Bosetti C et al (2009) Food groups and endometrial cancer risk: a case–control study from Italy. Am J Obstet Gynecol 200:293 e1–293 e7
McCann SE, Yeh M, Rodabaugh K, Moysich KB (2009) Higher regular coffee and tea consumption is associated with reduced endometrial cancer risk. Int J Cancer 124:1650–1653
Stensvold I, Jacobsen BK (1994) Coffee and cancer: a prospective study of 43,000 Norwegian men and women. Cancer Causes Control 5:401–408
Goodman MT, Hankin JH, Wilkens LR et al (1997) Diet, body size, physical activity, and the risk of endometrial cancer. Cancer Res 57:5077–5085
Levi F, Franceschi S, Negri E, La Vecchia C (1993) Dietary factors and the risk of endometrial cancer. Cancer 71:3575–3581
Kalandidi A, Tzonou A, Lipworth L, Gamatsi I, Filippa D, Trichopoulos D (1996) A case–control study of endometrial cancer in relation to reproductive, somatometric, and life-style variables. Oncology 53:354–359
Yang CS, Lambert JD, Sang S (2009) Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch Toxicol 83:11–21
Zheng W, Doyle TJ, Kushi LH, Sellers TA, Hong CP, Folsom AR (1996) Tea consumption and cancer incidence in a prospective cohort study of postmenopausal women. Am J Epidemiol 144:175–182
Gao J, Xiang YB, Xu WH et al (2005) Green tea consumption and the risk of endometrial cancer: a population-based case–control study in urban Shanghai. Zhonghua Liu Xing Bing Xue Za Zhi 26:323–327
Xu WH, Dai Q, Xiang YB et al (2007) Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer. Am J Epidemiol 166:1420–1430
La Vecchia C, Negri E, Franceschi S, D’Avanzo B, Boyle P (1992) Tea consumption and cancer risk. Nutr Cancer 17:27–31
Salazar-Martinez E, Lazcano-Ponce E, Sanchez-Zamorano LM, Gonzalez-Lira G, Escudero de los Rios P, Hernandez-Avila M (2005) Dietary factors and endometrial cancer risk. Results of a case–control study in Mexico. Int J Gynecol Cancer 15:938–945
Boehm K, Borrelli F, Ernst E et al (2009) Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev:CD005004
Kakuta Y, Nakaya N, Nagase S et al (2009) Case–control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma. Cancer Causes Control 20:617–624
Wu T, Willett WC, Hankinson SE, Giovannucci E (2005) Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in U.S. women. Diabetes Care 28:1390–1396
Tea Association of the USA (2008) Tea Fact Sheet. (www.teaUSA.org)
Mulholland HG, Murray LJ, Cardwell CR, Cantwell MM (2008) Dietary glycaemic index, glycaemic load and endometrial and ovarian cancer risk: a systematic review and meta-analysis. Br J Cancer 99:434–441
Hartge P (2006) Participation in population studies. Epidemiology 17:252–254
Galea S, Tracy M (2007) Participation rates in epidemiologic studies. Ann Epidemiol 17:643–653
We thank the interviewers and students who were involved in this study, the New Jersey Department of Health and Senior Services personnel, as well as all the participants who generously donated their time to the study. Funding: This work was funded by NIH-K07 CA095666 and R01CA83918.
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Bandera, E.V., Williams-King, M.G., Sima, C. et al. Coffee and tea consumption and endometrial cancer risk in a population-based study in New Jersey. Cancer Causes Control 21, 1467–1473 (2010). https://doi.org/10.1007/s10552-010-9575-9
- Endometrial cancer