Cancer Causes & Control

, Volume 21, Issue 5, pp 697–707 | Cite as

Parkinson’s disease and cancer risk: a systematic review and meta-analysis

  • Archna Bajaj
  • Jane A. Driver
  • Eva S. Schernhammer
Original Paper

Abstract

Objective

To appraise the existing literature on cancer risk among patients with Parkinson’s disease (PD), determine the overall cancer risk ratio among patients with PD, explore reasons for variations in study results, and assess the potential for publication bias.

Methods

Studies reporting cancer risk in patients with PD were identified by searching electronic databases through 18 November 2009 using the terms PARKINSON DISEASE, NEOPLASM, and CANCER. Reviewers individually performed data extraction and scored each study using a quality assessment instrument. Cancer risk in all patients with PD was calculated overall, and after excluding melanoma and other skin cancers. We tested for heterogeneity and publication bias, and stratified for gender, smoking-related versus non-smoking-related cancers, and study quality. We pooled effect sizes using fixed-effects and random-effects models.

Results

We included 29 studies in the overall analysis for a total of 107,598 patients with PD. Compared to controls, the aggregate risk for cancer in patients with PD was 0.73 (95% confidence interval [CI], 0.63–0.83), and after excluding skin tumors, 0.69 (95% CI, 0.62–0.78). These risks varied by gender (males, RR = 0.71, 95% CI, 0.57–0.88; females, RR = 0.82; 95% CI, 0.68–0.98). After strictly excluding skin tumors, both smoking-related (RR = 0.61; 95% CI, 0.58–0.65) and non-smoking-related cancer rates (RR = 0.76; 95% CI, 0.65–0.89) were significantly lower among patients with PD .

Conclusions

Studies on cancer risk among patients with PD collectively show significantly reduced cancer risk ratios. Further research to explain the biological mechanisms, particularly for the association with non-smoking-related cancers, appears warranted.

Keywords

Neurodegenerative diseases Neoplasm Meta-analysis 

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Archna Bajaj
    • 1
    • 2
  • Jane A. Driver
    • 3
    • 4
  • Eva S. Schernhammer
    • 1
    • 5
    • 6
  1. 1.Channing Laboratory, Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Case Western Reserve University School of MedicineClevelandUSA
  3. 3.Division of Aging, Department of MedicineBrigham and Women’s HospitalBostonUSA
  4. 4.Geriatric Research, Education and Clinical CenterBoston VA Healthcare SystemBostonUSA
  5. 5.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  6. 6.LBI-ACR-CTO & ACR-ITR VIEnna/CEADDPViennaAustria

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