Cancer Causes & Control

, Volume 21, Issue 3, pp 463–472

Blood pressure and risk of prostate cancer: cohort Norway (CONOR)

  • Richard M. Martin
  • Lars Vatten
  • David Gunnell
  • Pål Romundstad
Original paper

DOI: 10.1007/s10552-009-9477-x

Cite this article as:
Martin, R.M., Vatten, L., Gunnell, D. et al. Cancer Causes Control (2010) 21: 463. doi:10.1007/s10552-009-9477-x

Abstract

Background

Some studies suggest that raised blood pressure may increase prostate cancer risk. We investigated associations of blood pressure with prostate cancer within the CONOR collaborative cohorts of Norway.

Methods

Between 1994 and 2003, 82,098 men from ten population-based cohorts in Norway completed standardised questionnaires and physical examinations, including resting blood pressure. The unique 11-digit identification number of Norwegian citizens allowed linkage with the Cancer Registry of Norway.

Results

A total of 78,768 (96%) men who were cancer-free at baseline and average age of 50.3 years (standard deviation, SD: 15.2) were followed up for a mean of 9.15 years. 11.4% of these men used antihypertensive drugs at baseline. During follow-up (1994–2006), 1,974 incident prostate cancers were diagnosed. We found a 4% (95% confidence interval, CI = 0–9%) increased risk of prostate cancer per one SD (18.3 mmHg) increase in systolic blood pressure and similar findings for diastolic blood pressure (hazard ratio, HR: 1.05 per SD; 95% CI = 1.01–1.10). The association was stronger for advanced (HR: 1.16 per SD increase in systolic blood pressure; 95% CI = 1.05–1.27) compared with localised (1.01; 0.95–1.08) prostate cancer (p for heterogeneity in hazard ratios = 0.02).

Conclusions

Raised blood pressure was associated with an increased risk of prostate cancer, particularly advanced cancers at diagnosis. Understanding the mechanisms underlying these findings may provide biological insights into prostate carcinogenesis. Even if the association was causal, our data suggest that raised blood pressure would account for only 3% of prostate cancers, so the public health impact of this association may be limited.

Keywords

Prostate cancer Blood pressure Anti-hypertensives Prostate cancer mortality 

Supplementary material

10552_2009_9477_MOESM1_ESM.doc (78 kb)
(DOC 78 kb)

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Richard M. Martin
    • 1
  • Lars Vatten
    • 1
    • 2
  • David Gunnell
    • 1
  • Pål Romundstad
    • 2
  1. 1.Department of Social MedicineUniversity of BristolBristolUK
  2. 2.Department of Public HealthNorwegian University of Science and TechnologyTrondheimNorway

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