Abstract
Objectives
To explore whether the inverse association of sun exposure with non Hodgkin lymphoma among adults is also evident among the childhood population and test the specificity of the relation by contrasting the findings to those for Hodgkin lymphoma.
Methods
A total of 87 cases of childhood (0–14 years) with non Hodgkin lymphoma and 71 with Hodgkin lymphoma, diagnosed in Greece through the national network of childhood Hematology-Oncology Units, during a 7-year period, along with 164 age- and gender-matched control children were enrolled in the study. The guardians of all eligible children were interviewed in person on the basis of a structured questionnaire covering socio-demographic, anthropometric, and perinatal characteristics. Average time of sunbathing per year at a seaside resort was used as a proxy variable of exposure to sun controlling for use of sun protection measures.
Results
The estimated incidence of 10.2 cases per 1,000,000 children-years {95% Confidence Intervals (CI), 8.4–12.1} for NHL during the study period in Greece is around the average figure in countries of the European Union. There was an inverse association of sun exposure with Non Hodgkin lymphoma, namely, for an increment of 15 days of sunbathing at seaside resorts children had almost 40% lower risk (Odds Ratio: 0.60, 95% CI: 0.43–0.83), whereas no such association was evident for Hodgkin lymphoma. The risk for non Hodgkin lymphoma has been found to be statistically and significantly higher in birth weight (Odds ratio: 1.42 and 95% CI, 1.04–1.92, for every 500 g increment), whereas there was no substantial indication that maternal education or maternal smoking during the child’s life were important risk factors for the disease.
Conclusions
This is the first study to provide epidemiological evidence that increased sun exposure of children may also be associated with a decreased risk of developing childhood non Hodgkin, but not Hodgkin lymphoma.
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References
Percy C, Smith M, Linet M, Ries LAG, Friedman DL (1999) Lymphomas and reticuloendothelial neoplasms. In: Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL, Bunin GR (eds) Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995, National Cancer Institute, SEER Program. NIH, Bethesda Pub No. 99-4649
Stiller CA (1998) What causes Hodgkin’s disease in children? Eur J Cancer 34:523–528
Jarrett RF, Armstrong AA, Alexander E (1996) Epidemiology of EBV and Hodgkin’s lymphoma. Ann Oncol 7:5–10
Melby M, Adami H (2002) Hodgkin’s lymphoma. In: Adami H, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology. Oxford University Press, New York, pp 520–534
Ambinder RF, Lemas MV, Moore S, Yang J, Fabian D, Krone C (1999) Ebstein-Barr virus and lymphoma. Cancer Treat Res 99:27–45
Hjalgrim H, Askling J, Sorensen P et al (2000) Risk of Hodgkin’s disease and other cancers after infectious mononucleosis. J Natl Cancer Inst 92:1522–1528
Gutensohn N, Cole P (1977) Epidemiology of Hodgkin’s disease in the young. Int J Cancer 19:595–604
Alexander FE, Ricketts TJ, McKinney PA, Cartwright RA (1991) Community lifestyle characteristics and incidence of Hodgkin’s disease in young people. Int J Cancer 48:10–14
Nyari TA, Dickinson HO, Hammal DM, Parker L (2003) Childhood solid tumors in relation to population mixing around the time of birth. Br J Cancer 88:1370–1374
Petridou E, Andrie E, Dessypris N, Dikalioti SK, Trichopoulos D, The Childhood Hematology-Oncology Group (2006) Incidence and characteristics of childhood Hodgkin’s lymphoma in Greece: a nationwide study. Cancer Causes Control 17:209–215
Vianna NJ, Lawrence CE, Davies JN et al (1980) Tonsillectomy and childhood Hodgkin’s disease. Lancet 2:338–340
Mack TM, Cozen W, Shibata DK et al (1995) Concordance for Hodgkin’s disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease. N Engl J Med 332:413–418
John EM, Savitz DA, Sandler DP (1991) Prenatal exposure to parents’ smoking and childhood cancer. Am J Epidemiol 133:123–132
Sorahan T, Lancashire R, Prior P, Peck I, Stewart A (1995) Childhood cancer and parental use of alcohol and tobacco. Ann Epidemiol 5:354–359
Becker N, Deeg E, Nieters A (2004) Population-based study of lymphoma in Germany: rationale, study design and first results. Leuk Res 28:713–724
Shu XO, Jin F, Linet MS et al (1994) Diagnostic X-ray and ultrasound exposure and risk of childhood cancer. Br J Cancer 70:531–536
Adami J, Glimelius B, Cnattingius S et al (1996) Maternal and perinatal factors associated with non-Hodgkin’s lymphoma among children. Int J Cancer 65:774–777
Smulevich VB, Solionova LG, Belyakova SV (1999) Parental occupation and other factors and cancer risk in children: I. Study methodology and non-occupational factors. Int J Cancer 83:712–717
Niedobitek G, Young LS, Herbst H (1997) Epstein-Barr virus infection and the pathogenesis of malignant lymphomas. Cancer Surv 30:143–162
Kersey JH, Shapiro RS, Filipovich AH (1988) Relationship of immunodeficiency to lymphoid malignancy. Pediatr Infect Dis J 7:S10–S12
Taylor AM, Metcalfe JA, Thick J, Mak YF (1996) Leukemia and lymphoma in ataxia telangiectasia. Blood 87:423–438
McClain KL, Joshi VV, Murphy SB (1996) Cancers in children with HIV infection. Hematol Oncol Clin North Am 10:1189–1201
McMichael AJ, Giles GG (1996) Have increases in solar ultraviolet exposure contributed to the rise in incidence of non-Hodgkin’s lymphoma? Br J Cancer 73:945–950
Bentham G (1996) Association between incidence of non-Hodgkin’s lymphoma and solar ultraviolet radiation in England and Wales. BMJ 312:1128–1131
Langford IH, Bentham G, McDonald AL (1998) Mortality from non-Hodgkin’s lymphoma and UV exposure in the European community. Health Place 4:355–364
Boscoe FP, Schymura MJ (2006) Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993–2002. BMC Cancer 6:264
Hughes AM, Armstrong BK, Vajdic CM et al (2004) Sun exposure may protect against non-Hodgkin’s lymphoma: a case-control study. Int J Cancer 112:865–871
Smedby KE, Hjalgrim H, Melbye M et al (2005) Ultraviolet radiation exposure and risk of malignant lymphomas. J Natl Cancer Inst 97:199–209
Hartge P, Lim U, Freedman DM, Colt JS et al (2006) Ultraviolet radiation, dietary vitamin D, and risk of non-Hodgkin lymphoma (United States). Cancer Causes Control 17:1045–1052
SAS Institute Inc. 1989 SAS/STAT User’s Guide, Version 6, 4th edn. Cary, NC
ACCIS- Automated childhood cancer information system. Cancer incidence and survival by registry and tumour. Available at: http://www-dep.iarc.fr/accis.htm Last updated March 11, 2003
Hartge P, Devesa SS, Grauman D, Fears TR, Fraumeni JF Jr (1996) Non Hodgkin’s lymphoma and sunlight. J Natl Cancer Inst 88:298–300
Grant WB (2003) Ecologic studies of solar UV-B radiation and cancer mortality rates. Recent Results Cancer Res 164:371–377
Hu S, Ma F, Collado-Mesa F, Kirsner RS (2004) Ultraviolet radiation and incidence of non-Hodgkin’s lymphoma among Hispanics in the United States. Cancer Epidemiol Biomarkers Prev 13:59–64
Grant WB (2002) An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer 94:1867–1875
Newton R (1997) Solar ultraviolet radiation is not a major cause of primary cutaneous non-Hodgkin’s lymphoma. BMJ 314:1483–1484
Schuz J, Kaatsch P, Kaletsch U, Meinert R, Michaelis J (1999) Association of childhood cancer with factors related to pregnancy and birth. Int J Epidemiol 28:631–639
Petridou E, Trichopoulos D, Kalapothaki V et al (1997) The risk profile of childhood leukaemia in Greece: a nationwide case-control study. Br J Cancer 76:1241–1247
Hjalgrim LL, Rostgaard K, Hjalgrim H et al (2004) Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland. J Natl Cancer Inst 96:1549–1556
Skalkidou A, Petridou E, Papathoma E et al (2003) Determinants and consequences of major insulin-like growth factor components among full-term healthy neonates. Cancer Epidemiol Biomarkers Prev 12:860–865
Mucci LA, Granath F, Cnattingius S (2004) Maternal smoking and childhood leukemia and lymphoma risk among 1,440,542 Swedish children. Cancer Epidemiol Biomarkers Prev 13:1528–1533
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The Childhood Hematology-Oncology Group—Polychronopoulou Sophia, Department of Pediatric Hematology-Oncology, “Aghia Sophia” General Children's Hospital Athens, Greece. Moschovi Maria, Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, “Aghia Sophia” General Children's Hospital, Athens, Greece. Athanassiadou- Piperopoulou Fani, 2nd Department of Pediatrics, Aristotle University of Thessaloniki, AHEPA General Hospital, Greece. Pourtsidis Apostolos, Department of Pediatric Hematology –Oncology, “Pan.&Agl. Kyriakou” Children’s Hospital Athens, Greece. Kalmanti Maria, Department of Pediatric Hematology-Oncology, University Hospital of Heraklion, Heraklion, Greece.
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Petridou, E.T., Dikalioti, S.K., Skalkidou, A. et al. Sun exposure, birth weight, and childhood lymphomas: a case control study in Greece. Cancer Causes Control 18, 1031–1037 (2007). https://doi.org/10.1007/s10552-007-9044-2
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DOI: https://doi.org/10.1007/s10552-007-9044-2