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Breast density in relation to risk of ductal carcinoma in situ of the breast in women undergoing screening mammography

Cancer Causes & Control volume 18, pages 939–945 (2007)Cite this article

Abstract

Objective

To examine the association between breast density and risk of breast ductal carcinoma in situ (DCIS).

Methods

We assessed breast density in relation to DCIS risk using combined data from statewide mammography registries in NH and VT. The prospective analyses were based on 572 DCIS cases arising in 154,936 women (58,496 premenopausal and 96,440 postmenopausal). Women in the study were followed on average 4.1 years. Breast density was scored by community radiologists using BIRADS categories (fatty, scattered density, heterogeneous density, extreme density).

Results

In premenopausal women, based on 157 cases, the RR for DCIS risk were 0.29 (95% CI: 0.0.04, 2.24) for fatty breasts, 2.06 (95% CI: 1.39, 3.05) for heterogeneous density, and 2.40 (95% CI: 1.47, 3.91) for extreme density, relative to scattered density. In postmenopausal women, based on 369 cases, the RR for DCIS risk were 0.58 (95% CI: 0.37, 0.93) for fatty breasts, 1.41 (95% CI: 1.12, 1.78) for heterogeneous density, and 1.49 (95% CI: 0.93, 2.37) for extreme density, relative to scattered density. The possible interaction between breast density and menopausal status in relation to DCIS risk was not statistically significant.

Conclusions

We observed an association between breast density and DCIS risk. Although the association seemed stronger in premenopausal women, there was no evidence of an interaction involving breast density and menopausal status.

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Author information

Affiliations

  1. Department of Community & Family Medicine, Dartmouth Medical School, Norris Cotton Cancer Center, Hanover, NH, USA

    Todd A. MacKenzie, Linda Titus-Ernstoff, Julia E. Weiss, Martha E. Goodrich & Patricia A. Carney

  2. Department of Medicine, Dartmouth Medical School, Hanover, NH, USA

    Todd A. MacKenzie

  3. Department of Pediatrics, Dartmouth Medical School, Hanover, NH, USA

    Linda Titus-Ernstoff

  4. Dartmouth-Hitchcock Medical Center, One Medical Center Dr. HB 7927, Lebanon, NH, 03756, USA

    Linda Titus-Ernstoff

  5. Department of Medical Biostatistics, Vermont Cancer Center, University of Vermont, Burlington, VT, USA

    Pamela M. Vacek

  6. Health Promotions Research, Vermont Cancer Center, University of Vermont, Burlington, VT, USA

    Berta Geller

  7. Department of Family Medicine, Oregon Health and Science University, Portland, OR, USA

    Patricia A. Carney

Authors
  1. Todd A. MacKenzie
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  2. Linda Titus-Ernstoff
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  3. Pamela M. Vacek
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  4. Berta Geller
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  5. Julia E. Weiss
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  6. Martha E. Goodrich
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  7. Patricia A. Carney
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Correspondence to Linda Titus-Ernstoff.

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MacKenzie, T.A., Titus-Ernstoff, L., Vacek, P.M. et al. Breast density in relation to risk of ductal carcinoma in situ of the breast in women undergoing screening mammography. Cancer Causes Control 18, 939–945 (2007). https://doi.org/10.1007/s10552-007-9035-3

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  • DOI: https://doi.org/10.1007/s10552-007-9035-3

Keywords

  • Mammographic breast density
  • Breast cancer
  • Carcinoma in situ