Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract
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The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT).
We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case–control study comprising 811 UADT cancer cases and 1,083 controls.
An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95% CI = 1.19–4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95% CI = 0.50–0.98) for carriers of the minor allele.
To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.
KeywordsInterleukin-1 Interleukin-8 Cyclooxygenase-2 Upper aerodigestive tract cancers Oral cancer Pharynx cancer Larynx cancer Esophageal cancer
This work was supported by grants from the European Commission’s INCO-COPERNICUS Program (Contract No. IC15-CT98-0332), the US National Institutes of Health/National Cancer Institute (CA92039) and the World Cancer Research Foundation (WCRF 99A28). Daniele Campa was a recipient of a fellowship by the University of Pisa and a special training award by the International Agency for Research on Cancer.
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