Abstract
Objective
We conducted a population-based case–control study of epithelial ovarian cancer in relation to measures of body size and adult weight change. In particular, we sought to characterize the independent relation of body weight at particular ages with risk.
Methods
In-person interviews were sought with 35–54 year-old female residents of metropolitan Atlanta, Seattle or Detroit diagnosed with ovarian cancer during 1994–1998, and with controls sampled from these populations. Information provided by 355 cases and 1,637 controls was analyzed using unconditional logistic regression.
Results
The risk among women in the top tenth, relative to women in the lowest fourth, of the distribution of body weight at age 18 years was 1.5 (95% confidence interval, 1.0–2.2); at age 30, 1.9 (1.2–2.9); and 5 years before the reference date, it was 2.1 (1.4–3.3). While our results did not substantiate risk elevations reported in previous studies among subsets of women (e.g., with particular histologic tumor subtypes or according to past oral contraceptive use), we noted a particularly increased risk among women who reported 10 or more pounds gained during their first year of oral contraceptive use.
Conclusions
Our findings suggest that risk of epithelial ovarian cancer may be most closely linked with body weight in the relatively recent past (but before the time in which the disease may manifest as weight loss) among women who develop this disease during the years before or shortly after menopause.
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References
Purdie DM, Bain CJ, Webb PM, Whiteman DC, Pirozzo S (2001) Body size and ovarian cancer: case–control study and systematic review (Australia). Cancer Causes Control 12:855–863
Fairfield KM, Willett WC, Rosner BA, Manson JE, Speizer FE, Hankinson SE (2002) Obesity, weight gain, and ovarian cancer. Obstet Gynecol 100:288–296
Kuper H, Cramer DW, Titus-Ernstoff L (2002) Risk of ovarian cancer in the United States in relation to anthropometric measures: does the association depend on menopausal status? Cancer Causes Control 13:455–463
Rodriguez C, Calle EE, Fakrabadi-Shokoohi D, Jacobs EJ, Thun MJ (2002) Body mass index, height, and the risk of ovarian cancer mortality in a prospective cohort of postmenopausal women. Cancer Epidemiol Biomarkers Prev 11:822–828
Lukanova A, Toniolo P, Lundin E, Micheli A, Akmedkhanov A, Muti P et al. (2002) Body mass index in relation to ovarian cancer: a multi-centre nested case–control study. Int J Cancer 99:603–608
Dal Maso L, Franceschi S, Negri E, Conti E, Montella M, Vaccarella S (2002) Body size indices at different ages and epithelial ovarian cancer risk. Eur J Cancer 38:1769–1774
Engeland A, Tretli S, Bjorge T (2003) Height, body mass index, and ovarian cancer: a follow-up of 1.1 million Norwegian women. J Natl Cancer Inst 95:1244–1248
Jonsson F, Wok A, Pedersen NL, Lichtenstein P, Terry P, Ahlbom A et al. (2003) Obesity and hormone-dependent tumors: cohort and co-twin control studies based on the Swedish Twin Registry. Int J Cancer 106: 594–599
Lubin F, Chetrit A, Freedman LS, Alfandary E, Fishler Y, Nitzan H et al. (2003) Body mass index at age 18 years and during adult life and ovarian cancer risk. Am J Epidemiol 157:113–120
Schouten LJ, Goldbohm RA, van den Brandt PA (2003) Height, weight, weight change, and ovarian cancer risk in the Netherlands Cohort Study on Diet and Cancer. Am J Epidemiol 157:424–433
Rossing MA, Tang M-TC, Weiss L, Flagg E, Wicklund KG (2004) A case–control study of ovarian cancer in relation to infertility and the use of ovulation-inducing drugs. Am J Epidemiol 160:1070–1078
Marchbanks PA, McDonald JA, Wilson HG, Burnett NM, Daling JR, Bernstein L et al. (2002) The NICHD women’s contraceptive and reproductive experiences study: methods and operational results. Ann Epidemiol 12:213–221
Koprowski C, Coates RJ, Bernstein L (2001) Ability of young women to recall past body size and age at menarche. Obesity Res 9:478–485
WHO (2000) Obesity: preventing and managing the global epidemic. WHO Technical Report Series 894, WHO, Geneva
Breslow NE, Day NE (1980) The Analysis of Case–Control Studies. International Agency for Research on Cancer, Lyons, France
Stevens J, Keil JE, Waid LR, Gazes PC (1990) Accuracy of current, 4-year, and 28-year self-reported body weight in an elderly population. Am J Epidemiol 132:1156–1163
Casey VA, Cwyer JT, Berkey CS, Coleman KA, Gardner IV (1991) Long-term memory of body weight and past weight satisfaction: a longitudinal follow-up. Am J Clin Nutr 53:1493–1498
Key TJ, Allen NE, Verkaslo PK, Banks E (2001) Energy balance and cancer: the role of sex hormones. Proc Nutr Soc 60:81–89
Ballard-Barbash R (1994) Anthropometry and breast cancer: body size—a moving target. Cancer 74:1090–1100
Moshos S, Chan JL, Mantzoros CS (2002) Leptin and reproduction: a review. Fertil Steril 77:433–444
Pralong FP, Gaillard RC (2001) Neuroendocrine effects of leptin. Pituitary 4:25–32
Gallo MF, Grimes DA, Schulz KF, Helmerhorst FM (2004) Combination estrogen-progestin contraceptives and body weight: systematic review of randomized controlled trials. Obstet Gynecol 103:359–373
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Financial support: Provided by NIH grant number R01 HD32175.
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Rossing, M.A., Tang, MT.C., Flagg, E.W. et al. Body Size and Risk of Epithelial Ovarian Cancer (United States). Cancer Causes Control 17, 713–720 (2006). https://doi.org/10.1007/s10552-006-0010-1
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DOI: https://doi.org/10.1007/s10552-006-0010-1