Skip to main content

Variation in Plasma Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3: Personal and Lifestyle Factors (United States)

Abstract

Insulin-like growth factors (IGFs) play an important role in cell proliferation and apoptosis, and recent epidemiologic studies have suggested that circulating IGF-1 and IGF binding protein-3 (IGFBP-3) may be related to colorectal, breast, and prostate cancer risk. The purpose of this analysis was to investigate the role of various personal and lifestyle factors in the inter-individual variation of circulating IGF-1 and IGFPB-3. We measured plasma levels of IGF-1 and IGFBP-3 in a sequential sample of 333 population-based control subjects enrolled in the Seattle Colorectal Cancer Family Registry from August 1999 through December 2001, who had provided a blood sample. Total IGF-1 and IGFBP-3 were measured from plasma samples using ELISA assays. Interviewer-administered questionnaires collected data on various personal and lifestyle factors. Multivariate-adjusted linear regression was used to assess the associations between specific personal and lifestyle factors with IGF-1 and IGFBP-3 levels. Age, body mass index, and postmenopausal hormone use were statistically significantly inversely related to IGF-1 concentrations, and milk consumption was significantly positively related to IGF-1 levels. Only age was significantly related to circulating IGFBP-3. Although the sources of inter-individual variation of IGF-1 and IGFB-3 are not yet fully understood, this analysis provides some insights into factors that may contribute.

This is a preview of subscription content, access via your institution.

References

  1. JI Jones DR Clemmons (1995) ArticleTitleInsulin-like growth factors and their binding proteins: biological actions Endocr Rev 16 3–34 Occurrence Handle10.1210/er.16.1.3 Occurrence Handle7758431

    Article  PubMed  Google Scholar 

  2. PF Collett-Solberg P Cohen (1996) ArticleTitleThe role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action Endocrinol Metab Clin North Am 25 591–614 Occurrence Handle10.1016/S0889-8529(05)70342-X Occurrence Handle8879988

    Article  PubMed  Google Scholar 

  3. SM Firth RC Baxter (2002) ArticleTitleCellular actions of the insulin-like growth factor binding proteins Endocr Rev 23 824–854 Occurrence Handle10.1210/er.2001-0033 Occurrence Handle12466191

    Article  PubMed  Google Scholar 

  4. JM Chan MJ Stampfer J Ma P Gann JM Gaziano M Pollak E Giovannucci (2002) ArticleTitleInsulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer J Natl Cancer Inst 94 1099–1106

    Google Scholar 

  5. R Shi HJ Berkel H Yu (2001) ArticleTitleInsulin-like growth factor-I and prostate cancer: a meta-analysis Br J Cancer 85 991–996 Occurrence Handle10.1038/sj.bjc.6691961 Occurrence Handle11592771

    Article  PubMed  Google Scholar 

  6. B Djavan M Waldert C Seitz M Marberger (2001) ArticleTitleInsulin-like growth factors and prostate cancer World J Urol 19 225–233 Occurrence Handle10.1007/s003450100220 Occurrence Handle11550779

    Article  PubMed  Google Scholar 

  7. H Yu F Jin XO Shu BD Li Q Dai JR Cheng HJ Berkel W Zheng (2002) ArticleTitleInsulin-like growth factors and breast cancer risk in Chinese women Cancer Epidemiol Biomark Prev 11 705–712

    Google Scholar 

  8. RA Krajcik ND Borofsky S Massardo N Orentreich (2002) ArticleTitleInsulin-like growth factor I (IGF-I), IGF-binding proteins, and breast cancer Cancer Epidemiol Biomark Prev 11 1566–1573

    Google Scholar 

  9. PF Bruning J Van Doorn JM Bonfrer PA Van Noord CM Korse TC Linders AA Hart (1995) ArticleTitleInsulin-like growth-factor-binding protein 3 is decreased in early-stage operable pre-menopausal breast cancer Int J Cancer 62 266–270 Occurrence Handle7543079

    PubMed  Google Scholar 

  10. SE Hankinson WC Willet GA Colditz DJ Hunter DS Michaud B Deroo B Rosner FE Speizer M Pollak (1998) ArticleTitleCirculating concentrations of insulin-like growth factor-1 and risk of breast cancer Lancet 351 1393–1396 Occurrence Handle10.1016/S0140-6736(97)10384-1 Occurrence Handle9593409

    Article  PubMed  Google Scholar 

  11. K Bohlke DW Cramer D Trichopoulos CS Mantzoros (1998) ArticleTitleInsulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast Epidemiology 9 570–573 Occurrence Handle10.1097/00001648-199809000-00016 Occurrence Handle9730040

    Article  PubMed  Google Scholar 

  12. BD Li MJ Khosravi HJ Berkel A Diamandi MA Dayton M Smith H Yu (2001) ArticleTitleFree insulin-like growth factor-1 and breast cancer risk Int J Cancer 91 736–739 Occurrence Handle10.1002/1097-0215(200002)9999:9999<::AID-IJC1111>3.0.CO;2-# Occurrence Handle11267989

    Article  PubMed  Google Scholar 

  13. P Toniolo PF Bruning A Akhmedkhanov JM Bonfrer KL Koenig A Lukanova RE Shore A Zeleniuch-Jacquotte (2000) ArticleTitleSerum insulin-like growth factor-1 and breast cancer Int J Cancer 88 828–832 Occurrence Handle10.1002/1097-0215(20001201)88:5<828::AID-IJC22>3.0.CO;2-8 Occurrence Handle11072255

    Article  PubMed  Google Scholar 

  14. J Ma MN Pollak E Giovannucci JM Chan Y Tao CH Hennekens MJ Stampfer (1999) ArticleTitleProspective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3 J Natl Cancer Inst 91 620–625 Occurrence Handle10.1093/jnci/91.7.620 Occurrence Handle10203281

    Article  PubMed  Google Scholar 

  15. E Giovannucci MN Pollak EA Platz WC Willett MJ Stampfer N Majeed GA Colditz FE Speizer SE Hankinson (2000) ArticleTitleA prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women Cancer Epidemiol Biomark Prev 9 345–349

    Google Scholar 

  16. O Manousos J Souglakos C Bosetti A Tzonou V Chatzidakis D Trichopoulos HO Adami C Mantzoros (1999) ArticleTitleIGF-I and IGF-II in relation to colorectal cancer Int J Cancer 83 15–17 Occurrence Handle10.1002/(SICI)1097-0215(19990924)83:1<15::AID-IJC4>3.0.CO;2-Y Occurrence Handle10449601

    Article  PubMed  Google Scholar 

  17. H Yu MR Spitz J Mistry J Gu WK Hong X Wu (1999) ArticleTitlePlasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis J Natl Cancer Inst 91 151–156 Occurrence Handle10.1093/jnci/91.2.151 Occurrence Handle9923856

    Article  PubMed  Google Scholar 

  18. A Lukanova P Toniolo A Akhmedkhanov C Biessy NJ Haley RE Shore E Riboli S Rinaldi R Kaaks (2001) ArticleTitleA prospective study of insulin-like growth factor-I, IGF-binding proteins-1, -2 and -3 and lung cancer risk in women Int J Cancer 92 888–892 Occurrence Handle10.1002/ijc.1265 Occurrence Handle11351312

    Article  PubMed  Google Scholar 

  19. SJ London JM Yuan GS Travlos YT Gao RE Wilson RK Ross MC Yu (2002) ArticleTitleInsulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China J Natl Cancer Inst 94 749–754 Occurrence Handle12011225

    PubMed  Google Scholar 

  20. MR Spitz MJ Barnett GE Goodman MD Thornquist X Wu M Pollak (2002) ArticleTitleSerum insulin-like growth factor (IGF) and IGF-binding protein levels and risk of lung cancer: a case-control study nested in the beta-Carotene and Retinol Efficacy Trial Cohort Cancer Epidemiol Biomark Prev 11 1413–1418

    Google Scholar 

  21. M Pollak (2000) ArticleTitleInsulin-like growth factor physiology and cancer risk Eur J Cancer 36 1224–1228 Occurrence Handle10.1016/S0959-8049(00)00102-7 Occurrence Handle10882860

    Article  PubMed  Google Scholar 

  22. D Goodman-Gruen E Barrett-Connor (1997) ArticleTitleEpidemiology of insulin-like growth factor-I in elderly men and women. The Rancho Bernardo Study Am J Epidemiol 145 970–976 Occurrence Handle9169905

    PubMed  Google Scholar 

  23. TB Harris D Kiel R Roubenoff J Langlois M Hannan R Havlik P WIlson (1997) ArticleTitleAssociation of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old: the Framingham Heart Study J Am Geriatr Soc 45 133–139 Occurrence Handle9033509

    PubMed  Google Scholar 

  24. LR Donahue SJ Hunter AP Sherblom C Rosen (1990) ArticleTitleAge-related changes in serum insulin-like growth factor-binding proteins in women J Clin Endocrinol Metab 71 575–579 Occurrence Handle1697597

    PubMed  Google Scholar 

  25. MD Holmes MN Pollak SE Hankinson (2002) ArticleTitleLifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations Cancer Epidemiol Biomark Prev 11 862–867

    Google Scholar 

  26. A Lukanova P Toniolo A Akhmedkhanov K Hunt S Rinaldi A Zeleniuch-Jacquotte NJ Haley E Riboli P Stattin E Lundin R Kaaks (2001) ArticleTitleA cross-sectional study of IGF-I determinants in women Eur J Cancer Prev 10 443–452 Occurrence Handle10.1097/00008469-200110000-00008 Occurrence Handle11711759

    Article  PubMed  Google Scholar 

  27. NE Allen PN Appleby R Kaaks S Rinaldi GK Davey TJ Key (2003) ArticleTitleLifestyle determinants of serum insulin-like growth-factor-1 (IGF-1), C-peptide and hormone binding protein levels in British women Cancer Causes Control 14 65–74 Occurrence Handle10.1023/A:1022518321634 Occurrence Handle12708727

    Article  PubMed  Google Scholar 

  28. S Chang X Wu H Yu MR Spitz (2002) ArticleTitlePlasma concentrations of insulin-like growth factors among healthy adult men and postmenopausal women: associations with body composition, lifestyle, and reproductive factors Cancer Epidemiol Biomark Prev 11 758–766

    Google Scholar 

  29. EA Platz MN Pollak EB Rimm N Majeed Y Tao WC Willet E Giovannucci (1999) ArticleTitleRacial variation in insulin-like growth factor-1 and binding protein-3 concentrations in middle-aged men Cancer Epidemiol Biomark Prev 8 1107–1110

    Google Scholar 

  30. H Jernstrom C Deal F Wilkin W Chu Y Tao N Majeed T Hudson SA Narod M Pollak (2001) ArticleTitleGenetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women Cancer Epidemiol Biomark Prev 10 377–384

    Google Scholar 

  31. D.R. Voskuil HB Mesquita Particlede R Kaaks PA Van Noord S Rinaldi E Riboli DE Grobbee PHM Peeters (2001) ArticleTitleDeterminants of circulating insulin-like growth factor (IGF)-I and IGF binding proteins 1–3 in premenopausal women: physical activity and anthropometry (Netherlands) Cancer Causes Control 12 951–958 Occurrence Handle10.1023/A:1013708627664 Occurrence Handle11808715

    Article  PubMed  Google Scholar 

  32. S Teramukai T Rohan H Eguchi T Oka K Shinchi S Kono (2002) ArticleTitleand behavioral correlates of insulin-like growth factor I and insulin-like growth factor binding protein-3 in middle-aged Japanese men Am J Epidemiol 156 344–348 Occurrence Handle10.1093/aje/kwf069 Occurrence Handle12181104

    Article  PubMed  Google Scholar 

  33. A Devine C Rosen S Mohan D Baylink RL Prince (1998) ArticleTitleEffects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women Am J Clin Nutr 68 200–206 Occurrence Handle9665115

    PubMed  Google Scholar 

  34. KH Schmitz RL Ahmed D Yee (2002) ArticleTitleEffects of a 9-month strenth training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30–50-year-old women Cancer Epidemiol Biomark Prev 11 1597–1604

    Google Scholar 

  35. AS Fairey KS Courneya CJ Field GJ Bell LW Jones JR Mackey (2003) ArticleTitleEffects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trial Cancer Epidemiol Biomark Prev 12 721–727

    Google Scholar 

  36. E Giovannucci M Pollak Y Liu EA Platz N Majeed EB Rimm WC Willett (2003) ArticleTitleNutritional predictors of insulin-like growth factor 1 and their relationships to cancer in men Cancer Epidemiol Biomark Prev 12 84–89

    Google Scholar 

  37. VG Kaklamani A Linos E Kaklamani I Markaki Y Koumantaki CS Mantzoros (1999) ArticleTitleDietary fat and carbohydrates are independently associated with circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 concentrations in healthy adults J Clin Oncol 17 3291–3298 Occurrence Handle10506632

    PubMed  Google Scholar 

  38. MD Holmes MN Pollak WC Willett SE Hankinson (2002) ArticleTitleDietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations Cancer Epidemiol Biomark Prev 11 852–861

    Google Scholar 

  39. PA Newcomb R Haile H Anton-Culver S Gallinger J Hopper JR Jass L LeMarchand NM Lindor JD Potter D Seminara (2002) ArticleTitleThe Colorectal Cancer Family Registry: 1998–2002 Cancer Epidemiol Biomark Prev 11 1222s–1223s

    Google Scholar 

  40. BE Ainsworth WL Haskell AS Leon DR Jacobs HJ Montoye JF Sallis RS Paffenbarger (1993) ArticleTitleCompendium of physical activities: classification of energy costs of human physical activities Med Sci Sports Exerc 25 71–80 Occurrence Handle8292105

    PubMed  Google Scholar 

  41. A Juul P Bang NT Hertel K Main P Dalgaard K Jorgensen J Muller K Hall NE Skakkebaek (1994) ArticleTitleSerum insulin-like growth factor-I in health children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index J␣Clin Endocrinol Metab 78 744–752 Occurrence Handle10.1210/jc.78.3.744 Occurrence Handle8126152

    Article  PubMed  Google Scholar 

  42. JM Chan MJ Stampfer E Giovannucci PH Gann J Ma P Wilkinson CH Hennekens M Pollak (1998) ArticleTitlePlasma insulin-like growth factor-1 and prostate cancer risk: a prospective study Science 279 563–566 Occurrence Handle10.1126/science.279.5350.563 Occurrence Handle9438850

    Article  PubMed  Google Scholar 

  43. PJ Kelly JA Eisman MC Stuart NA Pocock PN Sambrook TH Gwinn (1990) ArticleTitleSomatomedin-C, physical fitness, and bone density J Clin Endocrinol Metab 70 718–23 Occurrence Handle2307727

    PubMed  Google Scholar 

  44. K Landin-Wilhelmsen L Wilhelmsen G Lappas T Rosen G Lindstedt PA Lundberg BA Bengtsson (1994) ArticleTitleSerum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin Clin Endocrinol 41 351–357

    Google Scholar 

  45. RE Schoen J Schragin JL Weissfeld FL Thaete RW Evans CJ Rosen LH Kuller (2002) ArticleTitleLack of association between adipose tissue distribution and IGF-1 and IGFBP-3 in men and women Cancer Epidemiol Biomark Prev 11 581–586

    Google Scholar 

  46. JA Janssen RP Stolk HA Pols DE Grobbee FH Jong Particlede SW Lamberts (1998) ArticleTitleSerum free IGF-1, total IGF-1, IGFBP-1 and IGFBP-3 levels in an elderly population: relation to age and sex steroid levels Clin Endocrinol 48 471–478 Occurrence Handle10.1046/j.1365-2265.1998.00300.x

    Article  Google Scholar 

  47. LB Signorello H Kuper P Lagiou J Wuu LA Mucci D Trichopoulos HO Adami (2000) ArticleTitleLifestyle factors and insulin-like growth factor 1 levels among elderly men Eur J Cancer Prev 9 173–178 Occurrence Handle10.1097/00008469-200006000-00005 Occurrence Handle10954256

    Article  PubMed  Google Scholar 

  48. RB Colletti KC Copeland JT Devlin JD Roberts TL McAuliffe (1991) ArticleTitleEffect of obesity on plasma insulin-like growth factor-1 in cancer patients Int J Obes 15 523–527 Occurrence Handle1938095

    PubMed  Google Scholar 

  49. JD Veldhuis AY Liem S South A Weltman J Weltman DA Clemmons R Abbott T Mulligan ML Johnson S Pincus (1995) ArticleTitleDifferential impact of age, sex, steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in ultrasensitive chemiluminescence assay J Clin Endocrinol Metab 80 3209–3222 Occurrence Handle10.1210/jc.80.11.3209 Occurrence Handle7593428

    Article  PubMed  Google Scholar 

  50. D Rudman DE Mattson (1994) ArticleTitleSerum insulin-like growth factor in healthy older men in relation to physical activity J Am Geriatr Soc 42 71–76 Occurrence Handle8277119

    PubMed  Google Scholar 

  51. F Horber S Kohler K Lippuner P Jaeger (1996) ArticleTitleEffect of regular physical activity on age-associated alteration of body composition in men Eur J Clin Investig 26 279–285 Occurrence Handle10.1046/j.1365-2362.1996.124281.x

    Article  Google Scholar 

  52. R Heaney D McCarron B Dawson-Hughes S Oparil S Berga J Stern S Barr C. Rosen (1999) ArticleTitleDietary changes favorably affect bone remodeling in older adults Am Diet Assoc 99 1229–1233

    Google Scholar 

  53. J Ma E Giovannucci M Pollak JM Chan JM Gaziano WC Willett MJ Stampfer (2001) ArticleTitleMilk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men J␣Natl Cancer Inst 93 1330–1336 Occurrence Handle10.1093/jnci/93.17.1330 Occurrence Handle11535708

    Article  PubMed  Google Scholar 

  54. H Yu T Rohan (2000) ArticleTitleRole of the insulin-like growth factor family in cancer development and progression J Natl Cancer Inst 92 1472–1489 Occurrence Handle10.1093/jnci/92.18.1472 Occurrence Handle10995803

    Article  PubMed  Google Scholar 

  55. E Corpas SM Harman MR Blackman (1993) ArticleTitleHuman growth hormone and human aging Endocr Rev 14 20–39 Occurrence Handle10.1210/er.14.1.20 Occurrence Handle8491152

    Article  PubMed  Google Scholar 

  56. C Deal J Ma F Wilkin J Paquette F Rozen B Ge T Hudson MJ Stampfer MN Pollak (2001) ArticleTitleNovel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators J Clin Endocrinol Metab 86 1274–1280 Occurrence Handle10.1210/jc.86.3.1274 Occurrence Handle11238520

    Article  PubMed  Google Scholar 

  57. NM Probst-Hensch H Wang VHH Goh A Seow H-P Lee MC Yu (2003) ArticleTitleDeterminants of circulating insulin-like growth factor 1 and insulin-like growth factor binding protein 3 concentrations in a cohort of Singapore men and women Cancer Epidemiol Biomark Prev 12 739–746

    Google Scholar 

  58. H Jernstrom W Chu D Vesprini Y Tao N Majeed C Deal M Pollak SA Narod (2001) ArticleTitleGenetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk Mol Genet Metab 72 144–154 Occurrence Handle10.1006/mgme.2000.3130 Occurrence Handle11161840

    Article  PubMed  Google Scholar 

  59. E Giovannucci (2001) ArticleTitleInsulin, insulin-like growth factors and colon cancer: a review of the evidence J Nutr 131 3109S–3120S Occurrence Handle11694656

    PubMed  Google Scholar 

  60. A Lukanova E Lundin A Zeleniuch-Jacquotte P Muti A Mure S Rinaldi L Dossus A Micheli A Arslan P Lenner RE Shore V Krogh KL Koenig E Riboli F Berrino G Hallmans P Stattin P Toniolo R Kaaks (2004) ArticleTitleBody mass index, circulating levels of sex-steroid hormones, IGF-1 and IGF-binding protein-3: a cross-sectional study in healthy women Eur J Endocrinol, 150 161–171

    Google Scholar 

  61. A Lukanova S Soderberg P Stattin R Palmqvist E Lundin C Biessy S Rinaldi E Riboli G Hallmans R Kaaks (2002) ArticleTitleNonlinear relationship of insulin-like growth factor (IGF)-1 and IGF-1/IGF-binding protein-3 ratio with indices of adiposity and plasma insulin concentrations (Sweden) Cancer Causes Control 13 509–516 Occurrence Handle10.1023/A:1016392129279 Occurrence Handle12195640

    Article  PubMed  Google Scholar 

  62. A McTiernan C Ulrich S Slate J Potter (1998) ArticleTitlePhysical activity and cancer etiology: associations and mechanisms Cancer Causes Control 9 487–509 Occurrence Handle10.1023/A:1008853601471 Occurrence Handle9934715

    Article  PubMed  Google Scholar 

  63. C Titchenal (1988) ArticleTitleExercise and food intake. What is the relationship? Sports Med 6 135–145 Occurrence Handle3055144

    PubMed  Google Scholar 

  64. GB Forbes MR Brown SL Welle LE Underwood (1989) ArticleTitleHormonal response to overfeeding Am J Clin Nutr 49 608–611 Occurrence Handle2648795

    PubMed  Google Scholar 

  65. A Alberg (2002) ArticleTitleThe influence of cigarette smoking on circulating concentration of antioxidant micronutrients Toxicology 180 121–137 Occurrence Handle10.1016/S0300-483X(02)00386-4 Occurrence Handle12324189

    Article  PubMed  Google Scholar 

  66. P Vestergaard AP Hermann H Orskov L Mosekilde (1999) ArticleTitleEffect of sex hormone replacement on the insulin-like growth factor system and bone mineral: a cross-sectional and longitudinal study in 595 perimenopausal women participating in the Danish Osteoporosis Prevention Study J Clin Endocrinol Metab 84 2286–2290 Occurrence Handle10.1210/jc.84.7.2286 Occurrence Handle10404791

    Article  PubMed  Google Scholar 

  67. A Heald PL Selby A White JM Gibson (2000) ArticleTitleProgestins abrogate estrogen-induced changes in the insulin-like growth factor axis Am J Obstet Gynecol 183 593–600 Occurrence Handle10.1067/mob.2000.106994 Occurrence Handle10992179

    Article  PubMed  Google Scholar 

  68. AJ Weissberger KK Ho L Lazarus (1991) ArticleTitleContrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor-1, and GH-binding protein in postmenopausal women J␣Clin Endocrinol 72 374–381

    Google Scholar 

  69. A Cano C Castelo-Branco JJ Tarin (1999) ArticleTitleEffect of menopause and different combined estradiol-progestin regimens on basal and growth hormone-releaseing hormone-stimulated serum growth hormone, insulin-like growth factor-1, insulin-like growth factor binding protein (IGFBP)-1, and IGFBP-3 levels Fertil Steril 71 261–267 Occurrence Handle10.1016/S0015-0282(98)00432-4 Occurrence Handle9988395

    Article  PubMed  Google Scholar 

  70. HJ Cardim CM Lopes D Giannella-Neta AM daFonseca JA Pinotti (2001) ArticleTitleThe insulin-like growth factor-I system and hormone replacement therapy Fertil Steril 75 282–287 Occurrence Handle10.1016/S0015-0282(00)01691-5 Occurrence Handle11172828

    Article  PubMed  Google Scholar 

  71. GYW Kam K-C Leung RC Baxter KKY Ho (2000) ArticleTitleEstrogens exert route- and dose-dependent effects on insulin-like growth factor (IGF)-binding protein-3 and the acid-labile subunit of the IGF ternary complex J Clin Endocrinol Metab 85 1918–1922 Occurrence Handle10.1210/jc.85.5.1918 Occurrence Handle10843175

    Article  PubMed  Google Scholar 

  72. D Goodman-Gruen E Barrett-Connor (1996) ArticleTitleEffect of replacement estrogen on insulin-like growth factor-1 in postmenopausal women: the Rancho Bernardo Study J Clin Endocrinol Metab 81 4268–4271 Occurrence Handle10.1210/jc.81.12.4268 Occurrence Handle8954026

    Article  PubMed  Google Scholar 

  73. WB Malarkey M Burleson JT Cacioppo K Poehlmann R Glaser JK Kiecolt-Glaser (1997) ArticleTitleDifferential effects of estrogen and medoxyprogesterone on basal and stress-induced growth hormone release, IGF-1 levels, and cellular immunity in postmenopausal women Endocrine 7 227–233 Occurrence Handle9549049

    PubMed  Google Scholar 

  74. JE Rossouw GL Anderson RL Prentice AZ LaCroix C Kooperberg ML Stefanick RD Jackson SA Beresford BV Howard KC Johnson JM Kotchen J Ockene (2002) ArticleTitleWriting Group for the Women’s Health Initiative, I. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial JAMA 288 321–333 Occurrence Handle12117397

    PubMed  Google Scholar 

  75. GL Anderson M Limacher AR Assaf T Bassford SA Beresford H Black D Bonds R Brunner R Brzyski B Caan R Chlebowski D Curb M Gass J Hays G Heiss S Hendrix BV Howard J Hsia A Hubbell R Jackson KC Johnson H Judd JM Kotchen L Kuller AZ LaCroix D Lane RD Langer N Lasser CE Lewis J Manson K Margolis J Ockene MJ O’Sullivan L Phillips RL Prentice C Ritenbaugh J Robbins JE Rossouw G Sarto ML Stefanick L Van Horn J Wactawski-Wende R Wallace S Wassertheil-Smoller WsHIS Committee (2004) ArticleTitleEffects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial JAMA 291 1769–1771 Occurrence Handle10.1001/jama.291.14.1769 Occurrence Handle15082705

    Article  PubMed  Google Scholar 

  76. A Lemay S Dodin I Cedrin L T-Lemay (1995) ArticleTitlePhasic serum lipid excursions occur during cyclical oral conjugated oestrogens but not during transdermal oestradiol sequentially combined with oral medroxyprogeterone acetate Clin Endocrinol 42 341–351

    Google Scholar 

  77. S Hulley H Grady T Bush C Furberg D Herrington B Riggs E Vittinghoff (1998) ArticleTitleRandomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women JAMA 280 605–613 Occurrence Handle10.1001/jama.280.7.605 Occurrence Handle9718051

    Article  PubMed  Google Scholar 

  78. H Jernstrom H Olsson (1994) ArticleTitleSuppression of plasma insulin-like growth factor-1 levels in healthy, nulliparous, young women using low dose oral contraceptives Gynecol Obstet Invest 38 261–265 Occurrence Handle7851812

    PubMed  Google Scholar 

  79. JP Thissen JM Ketelslegers LE Underwood (1994) ArticleTitleNutritional regulation of the insulin-like growth factors Endocr Rev 15 80–101 Occurrence Handle10.1210/er.15.1.80 Occurrence Handle8156941

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Polly A. Newcomb.

Additional information

 Support: This research was supported in part by National Cancer Institute Grants U01CA74794, R01CA76366, and R03CA94785, and by National Institute of Health training grant 5-T32-CA09168.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Morimoto, L., Newcomb, P., White, E. et al. Variation in Plasma Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3: Personal and Lifestyle Factors (United States). Cancer Causes Control 16, 917–927 (2005). https://doi.org/10.1007/s10552-005-2702-3

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10552-005-2702-3

Key words:

  • insulin-like growth factor-1
  • insulin-like growth factor binding protein-3
  • obesity
  • physical activity
  • hormone replacement therapy
  • milk
  • epidemiology.