Cancer Causes & Control

, Volume 16, Issue 8, pp 917–927 | Cite as

Variation in Plasma Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3: Personal and Lifestyle Factors (United States)

  • Libby M. Morimoto
  • Polly A. Newcomb
  • Emily White
  • Jeannette Bigler
  • John D Potter


Insulin-like growth factors (IGFs) play an important role in cell proliferation and apoptosis, and recent epidemiologic studies have suggested that circulating IGF-1 and IGF binding protein-3 (IGFBP-3) may be related to colorectal, breast, and prostate cancer risk. The purpose of this analysis was to investigate the role of various personal and lifestyle factors in the inter-individual variation of circulating IGF-1 and IGFPB-3. We measured plasma levels of IGF-1 and IGFBP-3 in a sequential sample of 333 population-based control subjects enrolled in the Seattle Colorectal Cancer Family Registry from August 1999 through December 2001, who had provided a blood sample. Total IGF-1 and IGFBP-3 were measured from plasma samples using ELISA assays. Interviewer-administered questionnaires collected data on various personal and lifestyle factors. Multivariate-adjusted linear regression was used to assess the associations between specific personal and lifestyle factors with IGF-1 and IGFBP-3 levels. Age, body mass index, and postmenopausal hormone use were statistically significantly inversely related to IGF-1 concentrations, and milk consumption was significantly positively related to IGF-1 levels. Only age was significantly related to circulating IGFBP-3. Although the sources of inter-individual variation of IGF-1 and IGFB-3 are not yet fully understood, this analysis provides some insights into factors that may contribute.

Key words:

insulin-like growth factor-1 insulin-like growth factor binding protein-3 obesity physical activity hormone replacement therapy milk epidemiology. 


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Copyright information

© Springer 2005

Authors and Affiliations

  • Libby M. Morimoto
    • 1
    • 2
  • Polly A. Newcomb
    • 1
    • 2
    • 3
  • Emily White
    • 1
    • 2
  • Jeannette Bigler
    • 1
  • John D Potter
    • 1
    • 2
  1. 1.Public Health SciencesFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Department of EpidemiologyUniversity of WashingtonSeattleUSA
  3. 3.Comprehensive Cancer CenterUniversity of WisconsinMadisonUSA

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