Cancer Causes & Control

, Volume 16, Issue 10, pp 1225–1234 | Cite as

MnSOD Val-9Ala Genotype, Pro- and Anti-oxidant Environmental Modifiers, and Breast Cancer Among Women on Long Island, New York

  • Mia M. GaudetEmail author
  • Marilie D. Gammon
  • Regina M. Santella
  • Julie A. Britton
  • Susan L. Teitelbaum
  • Sybil M. Eng
  • Mary Beth Terry
  • Jeannette T. Bensen
  • Jane Schroeder
  • Andrew F. Olshan
  • Alfred I. Neugut
  • Christine B. Ambrosone


Excessive oxidative stress may induce and promote breast carcinogenesis. Manganese superoxide dismutase (MnSOD) is critical to management of oxidative stress by catalyzing the formation of hydrogen peroxide from two superoxide anions. To examine the relationship between MnSOD Val-9Ala polymorphism, breast cancer and potential modifiers, we analyzed data from a large population-based case-control study. Study participants completed an in-home interviewer-administered questionnaire, and self-completed a Block food frequency questionnaire. Age-adjusted unconditional logistic models included 1034 cases and 1084 controls. As compared with Val/Val genotype, we found no association between MnSOD Ala/Val (OR = 0.98, 95% CI: 0.79–1.21) and Ala/Ala (OR = 1.00, 95% CI: 0.79–1.28) genotypes and breast cancer. Results did not differ by menopausal status, stage of tumor, or estrogen and progesterone receptor status. No discernable patterns of interaction were found between this MnSOD variant and anti-oxidative exposures, including fruit and vegetable intake or NSAID use, or pro-oxidant exposures, including smoking and alcohol. This study provides little evidence that variation in Val-9Ala polymorphism of MnSOD alone or through substantial interaction with key exposures believed to be pro- or anti-oxidant properties influences breast cancer risk.

Key words

breast cancer gene–environment interaction MnSOD 



body mass index


estrogen receptor


food frequency questionnaire


hormone receptor therapy


interaction contrast ratio


Long Island Breast Cancer Study Project


manganese superoxide dismutase


minor allele frequency


non-steroidal anti-inflammatory drugs


oral contraceptives


odds ratio


polycyclic aromatic hydrocarbons DNA


progesterone receptor


reactive oxygen species


superoxide dismutase

95% CI

95% confidence interval


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Copyright information

© Springer 2005

Authors and Affiliations

  • Mia M. Gaudet
    • 1
    Email author
  • Marilie D. Gammon
    • 1
  • Regina M. Santella
    • 2
  • Julie A. Britton
    • 3
  • Susan L. Teitelbaum
    • 3
  • Sybil M. Eng
    • 4
  • Mary Beth Terry
    • 5
  • Jeannette T. Bensen
    • 1
  • Jane Schroeder
    • 1
  • Andrew F. Olshan
    • 1
  • Alfred I. Neugut
    • 2
    • 6
  • Christine B. Ambrosone
    • 7
  1. 1.Department of Epidemiology, School of Public HealthUniversity of North CarolinaChapel HillUSA
  2. 2.Department of Environmental Health Sciences, Mailman School of Public HealthColumbia UniversityNew YorkUSA
  3. 3.Department of Community and Preventive MedicineMount Sinai School of Medicine New YorkUSA
  4. 4.Global EpidemiologyWorldwide Safety and Risk Management, Pfizer, IncNew YorkUSA
  5. 5.Department of EpidemiologyMailman School of Public HealthNew YorkUSA
  6. 6.Department of Medicine, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  7. 7.Department of Epidemiology Roswell Park Cancer InstituteBuffaloUSA

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