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Regular use of aspirin or acetaminophen and risk of non-Hodgkin lymphoma

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Abstract

Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of non-Hodgkin lymphoma (NHL), although previous results have been inconsistent. The current study investigated the effects of regular aspirin or acetaminophen use on non-Hodgkin lymphoma risk among 625 individuals with primary, incident NHL and 2512 age and sex matched hospital controls with non-neoplastic conditions who completed a comprehensive epidemiologic questionnaire. Results indicate that regular aspirin use may be associated with decreased NHL risk among men [adjusted odds ratio (aOR) 0.82, 95% confidence interval (CI), 0.65–1.04], but not among women (aOR 0.93, 95% CI, 0.71–1.23). In contrast, regular acetaminophen use was associated with elevated NHL risk among women (aOR 1.71, 95% CI, 1.18–2.50) but not among men (aOR 0.75, 95% CI, 0.48–1.17). Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed.

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Authors and Affiliations

  1. Department of Epidemiology, A-316 Carlton House, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    Julie A. Baker, Joli R. Weiss, Ravi J. Menezes, Christine B. Ambrosone & Kirsten B. Moysich

  2. Department of Medicine, Lymphoma/Myeloma Section, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA

    Myron S. Czuczman

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  1. Julie A. Baker
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  2. Joli R. Weiss
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  3. Myron S. Czuczman
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Correspondence to Kirsten B. Moysich.

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Baker, J.A., Weiss, J.R., Czuczman, M.S. et al. Regular use of aspirin or acetaminophen and risk of non-Hodgkin lymphoma. Cancer Causes Control 16, 301–308 (2005). https://doi.org/10.1007/s10552-004-3074-9

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  • DOI: https://doi.org/10.1007/s10552-004-3074-9

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